{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T03:07:10Z","timestamp":1774840030318,"version":"3.50.1"},"reference-count":0,"publisher":"Georg Thieme Verlag KG","issue":"06","license":[{"start":{"date-parts":[[2020,5,25]],"date-time":"2020-05-25T00:00:00Z","timestamp":1590364800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Endosc Int Open"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Background and study aims\u2002Helicobacter pylori-associated nodular gastritis, which is associated with follicular lymphoid hyperplasia, is mainly recognized in the antrum. However, we have also observed nodularity-like appearance in the cardia. This study aimed to investigate the clinical signi\ufb01cance of cardiac nodularity-like appearance in H. pylori-associated gastritis.<\/jats:p><jats:p>\n          Patients and methods\u2002Patients who underwent esophagogastroduodenoscopy and were evaluated for H. pylori infection for the \ufb01rst time were enrolled. A nodularity-like appearance in the cardia was defined as a miliary nodular appearance or scattered appearances of small circular whitish coloration. H. pylori infection was diagnosed according to serum anti-H. pylori antibody and the urea breath test or histology. Accuracy of the H. pylori infection diagnoses based on nodularity-like appearance were assessed.<\/jats:p><jats:p>\n          Results\u2002Among 265 patients, 42 patients (15.8\u200a%) were diagnosed as positive for H. pylori. Cardiac nodularity-like appearance and antral nodularity were recognized in 25 and 15 patients, respectively. In accuracy of predicting H. pylori by cardiac nodularity-like appearance, specificity was 0.996, sensitivity was 0.571, positive predictive value was 0.960, negative predictive value was 0.925, and accuracy was 0.928.\u200aThe sensitivity of cardiac nodularity-like appearance was significantly higher than that of antral nodularity (P\u200a=\u200a0.0284).<\/jats:p><jats:p>\n          Conclusions\u2002Cardiac nodularity-like appearance had a high accuracy rate for H. pylori infection diagnosis. Cardiac nodularity-like appearance was found more frequently than antral nodularity.<\/jats:p>","DOI":"10.1055\/a-1136-9890","type":"journal-article","created":{"date-parts":[[2020,5,25]],"date-time":"2020-05-25T22:31:04Z","timestamp":1590445864000},"page":"E770-E774","source":"Crossref","is-referenced-by-count":14,"title":["Nodularity-like appearance in the cardia: novel endoscopic findings for Helicobacter pylori infection"],"prefix":"10.1055","volume":"08","author":[{"given":"Osamu","family":"Toyoshima","sequence":"additional","affiliation":[{"name":"Gastroenterology, Toyoshima Endoscopy Clinic, Tokyo, Japan"},{"name":"Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshihiro","family":"Nishizawa","sequence":"additional","affiliation":[{"name":"Gastroenterology, Toyoshima Endoscopy Clinic, Tokyo, Japan"},{"name":"Department of Gastroenterology and Hepatology, International University of Health and Welfare, Mita Hospital, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kosuke","family":"Sakitani","sequence":"additional","affiliation":[{"name":"Gastroenterology, Toyoshima Endoscopy Clinic, Tokyo, Japan"},{"name":"Gastroenterology, Sakitani Endoscopy Clinic, Narashino, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tadahiro","family":"Yamakawa","sequence":"additional","affiliation":[{"name":"Gastroenterology, Toyoshima Endoscopy Clinic, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hidenobu","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Pathology and Cytology Laboratory Japan, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuntaro","family":"Yoshida","sequence":"additional","affiliation":[{"name":"Gastroenterology, Toyoshima Endoscopy Clinic, Tokyo, Japan"},{"name":"Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yousuke","family":"Nakai","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keisuke","family":"Hata","sequence":"additional","affiliation":[{"name":"Gastroenterology, Toyoshima Endoscopy Clinic, Tokyo, Japan"},{"name":"Department of Surgical Oncology, Graduate school of Medicine, The University of Tokyo, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hirotoshi","family":"Ebinuma","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, International University of Health and Welfare, Mita Hospital, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hidekazu","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Tokai University School of Medicine, Kanagawa, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuhiko","family":"Koike","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2020,5,25]]},"container-title":["Endoscopy International Open"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-1136-9890.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,25]],"date-time":"2020-05-25T22:31:09Z","timestamp":1590445869000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-1136-9890"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5,25]]},"references-count":0,"journal-issue":{"issue":"06","published-online":{"date-parts":[[2020,5,25]]},"published-print":{"date-parts":[[2020,6]]}},"URL":"https:\/\/doi.org\/10.1055\/a-1136-9890","relation":{},"ISSN":["2364-3722","2196-9736"],"issn-type":[{"value":"2364-3722","type":"print"},{"value":"2196-9736","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,5,25]]}}}