{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T09:48:50Z","timestamp":1769161730156,"version":"3.49.0"},"reference-count":0,"publisher":"Georg Thieme Verlag KG","issue":"05","funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation","doi-asserted-by":"crossref","award":["81600553"],"award-info":[{"award-number":["81600553"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation","doi-asserted-by":"crossref","award":["81270791"],"award-info":[{"award-number":["81270791"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation","doi-asserted-by":"crossref","award":["30800529"],"award-info":[{"award-number":["30800529"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Tianjin Municipal Science and Technology Commission Foundation","award":["14JCYBJC27900"],"award-info":[{"award-number":["14JCYBJC27900"]}]},{"name":"Tianjin Public Health Bureau Foundation","award":["2014KR16"],"award-info":[{"award-number":["2014KR16"]}]},{"name":"National Science and Technology Support Program","award":["2011BAI10B02"],"award-info":[{"award-number":["2011BAI10B02"]}]},{"name":"Shanxi Public Health Bureau Foundation","award":["201302051"],"award-info":[{"award-number":["201302051"]}]},{"name":"General Hospital of Tianjin Medical University Youth Incubation Foundation","award":["ZYYFY2015001"],"award-info":[{"award-number":["ZYYFY2015001"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Horm Metab Res"],"published-print":{"date-parts":[[2020,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The role of angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin\n                    receptor blockers (ARBs) in reducing the progression of albuminuria and risk of\n                    cardiovascular events in hypertensive patients with diabetic kidney disease\n                    (DKD) is well-documented. However, the efficacy and safety of these agents in\n                    normotensive patients with DKD are still controversial. MEDLINE, Embase, and\n                    Cochrane Library were searched for relevant random controlled trials. The odd\n                    risk (OR) reductions were calculated with a random-effects model. Decrease in\n                    albuminuria, changes in eGFR, major cardiovascular events, and drug-related\n                    adverse events were analyzed. Thirteen RCTs including 1282 patients were\n                    retrieved. Compared with placebo or other active agent groups, ACEIs or ARBs\n                    significantly decreased albuminuria (MD \u201380.28\u2009mg\/d,\n                    95% CI \u2013104.79\u2009mg\/d to\n                    \u201355.77\u2009mg\/d), and the efficacy is independent of changes\n                    in blood pressure and systolic blood pressure at baseline. The result of\n                    subanalysis showed the declining of albuminuria was more significantly in\n                    normotensive DKD patients with 2DM (p=0.005). No significant differences\n                    were found with regard to the declining of evaluated glomerular filtration rate\n                    (eGFR) (MD\n                        \u20130.29\u2009ml\/min\/1.73\u2009m2,\n                    95% CI \u20132.99 to\n                        2.41\u2009ml\/min\/1.73\u2009m2). There were\n                    no significant differences in the side effect of the drugs such as hypotension\n                    and hyperkalemia. This meta-analysis demonstrated that ACEIs or ARBs can\n                    decrease albuminuria to varying degree in normotensive patients with DKD, and\n                    better response occurred in patients with 2DM.<\/jats:p>","DOI":"10.1055\/a-1138-0959","type":"journal-article","created":{"date-parts":[[2020,3,27]],"date-time":"2020-03-27T23:40:52Z","timestamp":1585352452000},"page":"289-297","source":"Crossref","is-referenced-by-count":23,"title":["Effects of ACE Inhibitors and Angiotensin Receptor Blockers in\n                    Normotensive Patients with Diabetic Kidney Disease"],"prefix":"10.1055","volume":"52","author":[{"given":"Dandan","family":"He","sequence":"first","affiliation":[{"name":"Department of Nephrology, General Hospital of Tianjin Medical\n                    University, Tianjin, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yaru","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Nephrology, General Hospital of Tianjin Medical\n                    University, Tianjin, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Tianjin Chest Hospital,\n                    China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yue","family":"Xing","sequence":"additional","affiliation":[{"name":"Department of Nephrology, General Hospital of Tianjin Medical\n                    University, Tianjin, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yipeng","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Tianjin Public Health Bureau, Tianjin,\n                    China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fuzhen","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Statistics, Fenyang Hospital of Shanxi Province, Fenyang,\n                    China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junya","family":"Jia","sequence":"additional","affiliation":[{"name":"Department of Nephrology, General Hospital of Tianjin Medical\n                    University, Tianjin, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tiekun","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Nephrology, General Hospital of Tianjin Medical\n                    University, Tianjin, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Youxia","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Nephrology, General Hospital of Tianjin Medical\n                    University, Tianjin, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shan","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Nephrology, General Hospital of Tianjin Medical\n                    University, Tianjin, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2020,3,27]]},"container-title":["Hormone and Metabolic Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-1138-0959.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,13]],"date-time":"2020-05-13T22:33:29Z","timestamp":1589409209000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-1138-0959"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3,27]]},"references-count":0,"journal-issue":{"issue":"05","published-online":{"date-parts":[[2020,5,13]]},"published-print":{"date-parts":[[2020,5]]}},"URL":"https:\/\/doi.org\/10.1055\/a-1138-0959","relation":{},"ISSN":["0018-5043","1439-4286"],"issn-type":[{"value":"0018-5043","type":"print"},{"value":"1439-4286","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,3,27]]}}}