{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,4]],"date-time":"2022-04-04T22:31:08Z","timestamp":1649111468287},"reference-count":21,"publisher":"Georg Thieme Verlag KG","issue":"09","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Klin Monbl Augenheilkd"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title><jats:p>Hintergrund Die Rekanalisierung und bikanalikul\u00e4re Schienung der Tr\u00e4nenwege mit Silikonschlauch stellt bei erworbenen Tr\u00e4nenwegsstenosen eine Therapieoption dar, nach der h\u00e4ufig Restenosierungen beobachtet werden. Ziel war die Analyse des Therapieerfolges der Oggel-Sonden-Implantation nach Tr\u00e4nenwegssp\u00fclung und -sondierung, Erfassung weiterer Beschwerdemerkmale sowie ein Literaturvergleich.<\/jats:p><jats:p>Patienten\/Material und Methodik Die retrospektive Datenerhebung erfolgte mithilfe von Patientenakten sowie Fragebogen an Patienten und deren behandelnde Augenfach\u00e4rzte, in denen die subjektive Beschwerdefreiheit sowie weitere Beschwerdemerkmale zu 3 Zeitpunkten nach Oggel-Sonden-Explantation eruiert wurden: unmittelbar, nach 1 Monat und 1 Jahr. Eingeschlossen wurden 82 durchgef\u00fchrte Eingriffe an der Augenklinik des Universit\u00e4tsklinikums Ulm zwischen 2006 und 2015. Der Einfluss von Risikofaktoren auf den Therapieerfolg wurde statistisch mittels logistischer Regressionsanalyse und Mann-Whitney-U-Test bestimmt. Ein Untergruppenvergleich wurde mit dem Pearson-Chi-Quadrat-Test und dem Exakten Fisher-Test auf signifikante Unterschiede sowie mit einer Kaplan-Meier-Analyse determiniert.<\/jats:p><jats:p>Ergebnisse Direkt nach Oggel-Sonden-Explantation lag die Beschwerdefreiheit bei 80,8%, nach 1 Monat sank sie auf 61,6% und nach 1 Jahr betrug sie 42,5% im Patientenkollektiv (n\u2009=\u200982). Es zeigten sich keine signifikanten Unterschiede bez. Stenoselokalisation, Patientenalter oder Geschlecht. Ebenso konnte kein signifikanter Einfluss des Patientenalters, der pr\u00e4operativen Beschwerdedauer sowie von Risikofaktoren, die f\u00fcr Tr\u00e4nenwegsstenosen pr\u00e4disponieren, nachgewiesen werden. Eine Kaplan-Meier-Analyse lieferte f\u00fcr den Zeitraum eines Jahres eine Wahrscheinlichkeit der Beschwerdefreiheit von 52,2% f\u00fcr das Patientenkollektiv sowie eine mittlere Dauer der Beschwerdefreiheit von 34,2 Wochen.<\/jats:p><jats:p>Schlussfolgerung Die Ergebnisse erm\u00f6glichen eine prognostische Einsch\u00e4tzung des Therapieerfolges bei fehlenden signifikanten Unterschieden in den Untergruppen. Der Therapieerfolg nach Oggel-Sonden-Implantation lag im unteren Drittel vergleichbarer Studien. Die Ergebnisse des zeitlich progredient abnehmenden Therapieerfolges best\u00e4tigen die Beobachtungen anderer Studien. Der Literaturvergleich gestaltete sich methodisch erschwert aufgrund abweichender Studienmerkmale, f\u00fcr zuk\u00fcnftige Studien w\u00e4re eine Vereinheitlichung sinnvoll.<\/jats:p>","DOI":"10.1055\/a-1140-7124","type":"journal-article","created":{"date-parts":[[2020,7,13]],"date-time":"2020-07-13T22:49:30Z","timestamp":1594680570000},"page":"1093-1101","source":"Crossref","is-referenced-by-count":0,"title":["Rekanalisierung durch Sondierung mit Oggel-Sonden-Implantation bei erworbener Tr\u00e4nenwegsstenose"],"prefix":"10.1055","volume":"237","author":[{"given":"Markus Arthur","family":"Baier","sequence":"additional","affiliation":[{"name":"Augenklinik, Universit\u00e4tsklinikum Ulm"},{"name":"Klinikum Wolfsburg"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marek","family":"Mikielewicz","sequence":"additional","affiliation":[{"name":"Augenklinik, Universit\u00e4tsklinikum Ulm"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerhard K.","family":"Lang","sequence":"additional","affiliation":[{"name":"Augenklinik, Universit\u00e4tsklinikum Ulm"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00fcrgen","family":"Kampmeier","sequence":"additional","affiliation":[{"name":"Augenklinik, Universit\u00e4tsklinikum Ulm"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2020,7,13]]},"reference":[{"key":"ref2","first-page":"23","article-title":"Bicanalicular silicone intubation in acquired partial nasolacrimal duct obstruction","volume":"309\u200a\u2013\u200a310","author":"I Bleyen","year":"2008","journal-title":"Bull Soc Belge Ophthalmol"},{"key":"ref3","first-page":"5","article-title":"Randomized study comparing the efficacy of a self-retaining bicanaliculus intubation stent with Crawford intubation in patients with canalicular obstruction","volume":"6","author":"S Z Tabatabaie","year":"2012","journal-title":"Clin 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