{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T02:25:05Z","timestamp":1772504705777,"version":"3.50.1"},"reference-count":0,"publisher":"Georg Thieme Verlag KG","issue":"06","funder":[{"name":"The NIDDK","award":["K08DK109116"],"award-info":[{"award-number":["K08DK109116"]}]},{"DOI":"10.13039\/100000862","name":"The Doris Duke Charitable Foundation","doi-asserted-by":"crossref","award":["2019087"],"award-info":[{"award-number":["2019087"]}],"id":[{"id":"10.13039\/100000862","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Horm Metab Res"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Adrenal venous sampling is the standard of care for identifying patients with\n                    unilateral primary aldosteronism, which is often caused by an aldosterone\n                    producing adenoma and can be cured with surgery. The numerous limitations of\n                    adrenal venous sampling, including its high cost, scarce availability, technical\n                    challenges, and lack of standardized protocols, have driven efforts to develop\n                    alternative, non-invasive tools for the diagnosis of aldosterone producing\n                    adenomas. Seminal discoveries regarding the pathogenesis of aldosterone\n                    producing adenomas made over the past decade have leveraged hypotheses-driven\n                    research of steroid phenotypes characteristic of various aldosterone producing\n                    adenomas. In parallel, the expanding availability of mass spectrometry has\n                    enabled the simultaneous quantitation of many steroids in single assays from\n                    small volume biosamples. Steroid profiling has contributed to our evolving\n                    understanding about the pathophysiology of primary aldosteronism and its\n                    subtypes. Herein, we review the current state of knowledge regarding the\n                    application of multi-steroid panels in assisting with primary aldosteronism\n                    subtyping.<\/jats:p>","DOI":"10.1055\/a-1141-3526","type":"journal-article","created":{"date-parts":[[2020,4,24]],"date-time":"2020-04-24T23:35:29Z","timestamp":1587771329000},"page":"373-378","source":"Crossref","is-referenced-by-count":11,"title":["Developments in Primary Aldosteronism Subtyping Using Steroid\n                    Profiling"],"prefix":"10.1055","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5439-6894","authenticated-orcid":false,"given":"Taweesak","family":"Wannachalee","sequence":"additional","affiliation":[{"name":"Division of Metabolism, Endocrinology, and Diabetes, University of\n                    Michigan, Ann Arbor, MI, USA"},{"name":"Division of Endocrinology and Metabolism, Siriraj Hospital, Mahidol\n                    University, Bangkok, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9831-6190","authenticated-orcid":false,"given":"Adina F.","family":"Turcu","sequence":"additional","affiliation":[{"name":"Division of Metabolism, Endocrinology, and Diabetes, University of\n                    Michigan, Ann Arbor, MI, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2020,4,24]]},"container-title":["Hormone and Metabolic Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-1141-3526.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,6,16]],"date-time":"2020-06-16T22:31:28Z","timestamp":1592346688000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-1141-3526"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4,24]]},"references-count":0,"journal-issue":{"issue":"06","published-online":{"date-parts":[[2020,6,16]]},"published-print":{"date-parts":[[2020,6]]}},"URL":"https:\/\/doi.org\/10.1055\/a-1141-3526","relation":{},"ISSN":["0018-5043","1439-4286"],"issn-type":[{"value":"0018-5043","type":"print"},{"value":"1439-4286","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,4,24]]}}}