{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T01:08:15Z","timestamp":1782263295523,"version":"3.54.5"},"reference-count":0,"publisher":"Georg Thieme Verlag KG","issue":"06","funder":[{"name":"Ministry of Science and Technology","award":["MOST 106\u20132314-B-002\u2013048 \u2013MY3"],"award-info":[{"award-number":["MOST 106\u20132314-B-002\u2013048 \u2013MY3"]}]},{"name":"Ministry of Science and Technology","award":["MOST 106\u20132314-B-002\u2013169-MY3"],"award-info":[{"award-number":["MOST 106\u20132314-B-002\u2013169-MY3"]}]},{"DOI":"10.13039\/501100005762","name":"National Taiwan University Hospital","doi-asserted-by":"crossref","award":["NTUH 107-A141"],"award-info":[{"award-number":["NTUH 107-A141"]}],"id":[{"id":"10.13039\/501100005762","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Horm Metab Res"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Primary aldosteronism (PA) is the most common cause of secondary hypertension.\n                    Increasing evidence has demonstrated an increased cardiovascular risk in\n                    patients with PA compared to those with essential hypertension (EH), including\n                    atrial fibrillation (AF), the most prevalent arrhythmia among adults that is\n                    associated with an elevated risk of subsequent cerebro-cardiovascular adverse\n                    events. The mechanisms of increased prevalence of AF in PA patients are complex.\n                    Excessive aldosterone production is regarded to be a key component in the\n                    pathogenesis of AF, in addition to arterial hypertension and electrolyte\n                    imbalance. In addition, several translational and clinical studies have reported\n                    that structural remodeling with atrial fibrosis and electrical remodeling with\n                    arrhythmogenicity induced by an excess of aldosterone also play major roles in\n                    AF genesis. Clinical studies from several registries and meta-analysis have\n                    reported an increased prevalence and risk of AF in PA patients compared to EH\n                    patients. Recent trials have further demonstrated a reduction in the risk of\n                    new-onset atrial fibrillation (NOAF) after adrenalectomy, while the results of\n                    medical treatment with mineralocorticoid receptor antagonists (MRAs) have been\n                    inconsistent. This review outlines the current evidence of the relationship\n                    between PA and AF, and highlights recent progress in the management of PA with\n                    regards to the development of AF.<\/jats:p>","DOI":"10.1055\/a-1141-5989","type":"journal-article","created":{"date-parts":[[2020,4,14]],"date-time":"2020-04-14T22:57:21Z","timestamp":1586905041000},"page":"357-365","source":"Crossref","is-referenced-by-count":22,"title":["Atrial Fibrillation in Primary Aldosteronism"],"prefix":"10.1055","volume":"52","author":[{"given":"Chien-Ting","family":"Pan","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, National Taiwan University Hospital\n                    Yun-Lin Branch, Yun-Lin, Taiwan"},{"name":"Division of Cardiology, Department of Internal Medicine, National\n                    Taiwan University Hospital and National Taiwan University College of Medicine,\n                    Taipei, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng-Hsuan","family":"Tsai","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine, National\n                    Taiwan University Hospital and National Taiwan University College of Medicine,\n                    Taipei, Taiwan"},{"name":"Department of Internal Medicine, National Taiwan University Hospital\n                    Jin-Shan Branch, New Taipei City, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng-Wei","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, National Taiwan University Hospital\n                    Yun-Lin Branch, Yun-Lin, Taiwan"},{"name":"Division of Cardiology, Department of Internal Medicine, National\n                    Taiwan University Hospital and National Taiwan University College of Medicine,\n                    Taipei, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Yao","family":"Chang","sequence":"additional","affiliation":[{"name":"Cardiology Division of Cardiovascular Medical Center, Far Eastern\n                    Memorial Hospital, New Taipei City, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vin-Cent","family":"Wu","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Internal Medicine, National\n                    Taiwan University Hospital and National Taiwan University College of Medicine,\n                    Taipei, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chi-Sheng","family":"Hung","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine, National\n                    Taiwan University Hospital and National Taiwan University College of Medicine,\n                    Taipei, Taiwan"},{"name":"Cardiovascular Center, National Taiwan University Hospital, Taipei,\n                    Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yen-Hung","family":"Lin","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine, National\n                    Taiwan University Hospital and National Taiwan University College of Medicine,\n                    Taipei, Taiwan"},{"name":"Cardiovascular Center, National Taiwan University Hospital, Taipei,\n                    Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the TAIPAI Study Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2020,4,14]]},"container-title":["Hormone and Metabolic Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-1141-5989.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,6,16]],"date-time":"2020-06-16T22:31:25Z","timestamp":1592346685000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-1141-5989"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4,14]]},"references-count":0,"journal-issue":{"issue":"06","published-online":{"date-parts":[[2020,6,16]]},"published-print":{"date-parts":[[2020,6]]}},"URL":"https:\/\/doi.org\/10.1055\/a-1141-5989","relation":{},"ISSN":["0018-5043","1439-4286"],"issn-type":[{"value":"0018-5043","type":"print"},{"value":"1439-4286","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,4,14]]}}}