{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T04:55:54Z","timestamp":1758862554585},"reference-count":0,"publisher":"Georg Thieme Verlag KG","issue":"06","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Drug Res (Stuttg)"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n                        Background and objectives The pathogenesis of influenza infection is\n                        associated with two general processes in the body: (a) lung damage based on\n                        virus replication; (b) overproduction of free radicals, antioxidant\n                        deficiency, and development of oxidative stress. To attack these aspects of\n                        flu pathogenesis, we explored the combined effect of the antiviral agent\n                        oseltamivir, and s-adenosyl-l-methionine (SAM) as a precursor of the\n                        endogenous antioxidant glutathione, in mice infected with influenza\n                        virus.<\/jats:p><jats:p>\n                        Methods After inoculation of albino mice with 10 MLD50 of influenza\n                        virus A\/Aichi\/2\/68 (H3N2), oseltamivir was applied\n                        twice a day, for five days post-infection in doses of 1.25 and 2.5\n                        mg\/kg. SAM was administered once a day for 10 days, starting 5 days\n                        before infection in doses of 50, 100 and 150 mg\/kg.<\/jats:p><jats:p>\n                        Results Monotherapy with SAM did not influence the markers of\n                        oxidative stress in the lung. Combination of SAM 50 mg\/kg and\n                        oseltamivir 2.5 mg\/kg affected best the virological parameters -\n                        viral titer, protection index, and mean survival time, as well as the\n                        biochemical markers of oxidative stress.<\/jats:p><jats:p>\n                        Interpretation and conclusions Combining of SAM and oseltamivir in a\n                        dose of 1\/4 of optimal therapeutic could be considered as a\n                        perspective therapy of influenza viral infection.<\/jats:p>","DOI":"10.1055\/a-1147-8824","type":"journal-article","created":{"date-parts":[[2020,4,21]],"date-time":"2020-04-21T19:10:40Z","timestamp":1587496240000},"page":"273-279","source":"Crossref","is-referenced-by-count":5,"title":["Oseltamivir and S-Adenosyl-L-Methionine Combination as Effective\n                    Therapeutic Strategy for Suppression of Oxidative Damage in Lung Caused by\n                    Influenza Virus Infection in Mice"],"prefix":"10.1055","volume":"70","author":[{"given":"Milka","family":"Mileva","sequence":"additional","affiliation":[{"name":"The Stephan Angeloff Institute of Microbiology, Bulgarian Academy of\n                    Sciences, Sofia, Bulgaria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adriana","family":"Dimitrova","sequence":"additional","affiliation":[{"name":"The Stephan Angeloff Institute of Microbiology, Bulgarian Academy of\n                    Sciences, Sofia, Bulgaria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dimo","family":"Krastev","sequence":"additional","affiliation":[{"name":"Medical University of Sofia, Medical College, Sofia,\n                    Bulgaria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Albena","family":"Alexandrova","sequence":"additional","affiliation":[{"name":"Institute of Neurobiology, Bulgarian Academy of Sciences, Sofia,\n                    Bulgaria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elina","family":"Tsvetanova","sequence":"additional","affiliation":[{"name":"Institute of Neurobiology, Bulgarian Academy of Sciences, Sofia,\n                    Bulgaria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Almira","family":"Georgieva","sequence":"additional","affiliation":[{"name":"Institute of Neurobiology, Bulgarian Academy of Sciences, Sofia,\n                    Bulgaria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angel","family":"Galabov","sequence":"additional","affiliation":[{"name":"The Stephan Angeloff Institute of Microbiology, Bulgarian Academy of\n                    Sciences, Sofia, Bulgaria"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2020,4,21]]},"container-title":["Drug Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-1147-8824.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,28]],"date-time":"2020-05-28T02:47:10Z","timestamp":1590634030000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-1147-8824"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4,21]]},"references-count":0,"journal-issue":{"issue":"06","published-online":{"date-parts":[[2020,5,27]]},"published-print":{"date-parts":[[2020,6]]}},"URL":"https:\/\/doi.org\/10.1055\/a-1147-8824","relation":{},"ISSN":["2194-9379","2194-9387"],"issn-type":[{"value":"2194-9379","type":"print"},{"value":"2194-9387","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,4,21]]}}}