{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T03:30:52Z","timestamp":1764646252781},"reference-count":29,"publisher":"Georg Thieme Verlag KG","issue":"03","funder":[{"name":"public, commercial or not-for-profit sector"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Exp Clin Endocrinol Diabetes"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\nBackground Transsphenoidal surgery for sellar lesions may affect patency and function of the nasal airways, smell and sinonasal quality of life. Below is our report on otorhinolaryngological data garnered from patients undergoing endonasal transsphenoidal pituitary microsurgery.<\/jats:p><jats:p>\nMethods In a prospective study, 68 patients scheduled for transsphenoidal operations (32 female, 36 male, age 17\u201372 years) underwent otorhinolaryngological evaluation of their nasal morphology, a standardized smell test (sniffin\u2019 sticks) and rhinomanometry to analyse nasal breathing function preoperatively, 3\u20135 days postoperatively (without rhinomanometry), after 3\u20134 months and after 9 months.<\/jats:p><jats:p>\nResults Immediately after surgery, a reduction in smell sensation was detected in almost all patients. Within 3 months, this impairment resolved in all cases except one. In 2 patients (3%) with preoperative anosmia, improvement of smell function to&gt;6 out of 12 sniffin\u2019 sticks was observed. At final visit no patient was noted to have new anosmia. Within 3 months, the results of the rhinomanometry revealed that all patients except one, regained their preoperative nasal breathing function. In 6 patients (8.8%) an improvement in their nose breathing abilities compared to the preoperative state was found. Three patients (4.4%) underwent a LASER transection of mucosal synechiae. In one case with persistent nasal obstruction (1.5%), secondary septoplasty had to be performed. There was no case in which perforation of the nasal septum, nasal tip deflection, or saddle nose deformity was observed.<\/jats:p><jats:p>\nConclusion Microsurgical resection of pituitary tumors via the endonasal transsphenoidal approach poses an acceptable risk with regards to sinonasal complications. The incidence of secondary rhinosurgical interventions is low. Standardized comparative studies between endoscopic and microsurgical transsphenoidal operations should be undertaken.<\/jats:p>","DOI":"10.1055\/a-1155-6269","type":"journal-article","created":{"date-parts":[[2020,5,7]],"date-time":"2020-05-07T22:37:54Z","timestamp":1588891074000},"page":"157-162","source":"Crossref","is-referenced-by-count":5,"title":["Rhinological Consequences of Microsurgical Endonasal-Transsphenoidal Surgery for Pituitary Tumors"],"prefix":"10.1055","volume":"129","author":[{"given":"Nikolaos","family":"Hondronikos","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Johannes Wesling Hospital Minden, Minden, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali","family":"Alomari","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Johannes Wesling Klinikum, Universit\u00e4tsklinikum der Ruhruniversit\u00e4t Bochum, Minden, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Schrader","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Johannes Wesling Hospital Minden, Minden, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulrich J","family":"Knappe","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Johannes Wesling Klinikum, Universit\u00e4tsklinikum der Ruhruniversit\u00e4t Bochum, Minden, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2020,5,7]]},"reference":[{"key":"ref1","first-page":"933","article-title":"Transphenoidal removal of pituitary adenomas","volume":"91","author":"J Hardy","year":"1962","journal-title":"Union Med Can"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"140","DOI":"10.3171\/jns.1987.66.1.0140","article-title":"A direct transnasal approach to the sphenoid sinus. 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