{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T00:06:26Z","timestamp":1774397186026,"version":"3.50.1"},"reference-count":0,"publisher":"Georg Thieme Verlag KG","issue":"07","license":[{"start":{"date-parts":[[2020,6,15]],"date-time":"2020-06-15T00:00:00Z","timestamp":1592179200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Horm Metab Res"],"published-print":{"date-parts":[[2020,7]]},"abstract":"Abstract<\/jats:title>Variants of vitamin D metabolism-genes may predispose to type 2 diabetes (T2D).\n This study investigated the impact of these variants on disease susceptibility,\n Vitamin D, parathyroid hormone, C-peptide and HbA1c levels before and after\n cholecalciferol supplementation in patients with T2D.<\/jats:p>Twelve polymorphisms within CYP2R1, CYP27B1, DBP, VDR and CYP24A1 were genotyped\n in 553 T2D patients and 916 controls. In addition 65 patients receiving either\n cholecalciferol or placebo were analyzed during 6 months intervention and 6\n months follow-up.<\/jats:p>T2D risk alleles are VDR rs7975232 \u201cG\u201d\n (pc=0.031), rs1544410 \u201cG\u201d\n (pc=0.027) and CYP2R1 rs10741657 \u201cA\u201d\n (pc=0.016). Patients with genotypes CYP27B1 rs10877012\n \u201cCC\u201d (pc=4x10-5), DBP rs7041\n \u201cGG\u201d (pc=0.003), rs4588 \u201cCC\u201d\n (pc\u2009= 3x10-4), CYP24A1 rs2585426\n \u201cCG\u201d (pc=0.006) and rs2248137\n \u201cCG\u201d (pc=0.001) showed lower 25(OH)D3 and DBP\n rs4588 \u201cCC\u201d lower 1,25(OH)2D3 levels\n (pc=0.005). Whereas DBP rs4588 \u201cCC\u201d\n (pc=0.009), CYP27B1 rs10877012 \u201cAC\u201d\n (pc=0.059), VDR rs7975323 \u201cAG\u201d\n (pc=0.033) and rs1544410 \u201cGG\u201d\n (pc=0.013) are associated with higher 25(OH)D3 levels at\n 6 months\u2019 follow-up. Significant PTH suppression was detected for CYP2R1\n \u201cAG\u201c (pc=0.002), DBP rs4588\n \u201cCC\u201d (pc<0.001), VDR rs110735810\n \u201cCT\u201d (pc<0.001) and CYP24A1 rs2248137\n \u201cGG\u201d (pc=0.021).<\/jats:p>Genetic variants of the vitamin D system predispose to type 2 diabetes and\n regulate \u2013 partially - vitamin D metabolism, concentrations and the\n vitamin D status. Vitamin D insufficiency is a T2D risk factor. The response to\n cholecalciferol supplementation can be measured as 25(OH)D3 increment and PTH\n suppression. This process is regulated by genes of the vitamin D system\n conferring modest T2D risk.<\/jats:p>","DOI":"10.1055\/a-1157-0026","type":"journal-article","created":{"date-parts":[[2020,6,15]],"date-time":"2020-06-15T22:50:36Z","timestamp":1592261436000},"page":"492-499","source":"Crossref","is-referenced-by-count":14,"title":["Vitamin D in Type 2 Diabetes: Genetic Susceptibility and the Response\n to Supplementation"],"prefix":"10.1055","volume":"52","author":[{"given":"Marissa","family":"Penna-Martinez","sequence":"first","affiliation":[{"name":"Department of Internal Medicine I, Division of Endocrinology, Diabetes\n and Metabolism, Goethe-University Hospital, Frankfurt\/Main,\n Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Klaus","family":"Badenhoop","sequence":"first","affiliation":[{"name":"Department of Internal Medicine I, Division of Endocrinology, Diabetes\n and Metabolism, Goethe-University Hospital, Frankfurt\/Main,\n Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edith","family":"Klahold","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I, Division of Endocrinology, Diabetes\n and Metabolism, Goethe-University Hospital, Frankfurt\/Main,\n Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Franziska","family":"Bruns","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I, Division of Endocrinology, Diabetes\n and Metabolism, Goethe-University Hospital, Frankfurt\/Main,\n Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Seidl","sequence":"additional","affiliation":[{"name":"German Red Cross Blood Donor Service, Institute for Transfusion\n Medicine and Immunohaematology, Frankfurt\/Main, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sabine","family":"Wicker","sequence":"additional","affiliation":[{"name":"Occupational Health Service, Goethe-University Hospital,\n Frankfurt\/Main, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2020,6,15]]},"container-title":["Hormone and Metabolic Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-1157-0026.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,12,18]],"date-time":"2020-12-18T02:24:53Z","timestamp":1608258293000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-1157-0026"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6,15]]},"references-count":0,"journal-issue":{"issue":"07","published-online":{"date-parts":[[2020,7,17]]},"published-print":{"date-parts":[[2020,7]]}},"URL":"https:\/\/doi.org\/10.1055\/a-1157-0026","relation":{},"ISSN":["0018-5043","1439-4286"],"issn-type":[{"value":"0018-5043","type":"print"},{"value":"1439-4286","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,6,15]]}}}