{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T10:49:42Z","timestamp":1778582982770,"version":"3.51.4"},"reference-count":62,"publisher":"Georg Thieme Verlag KG","issue":"06","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Horm Metab Res"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Primary aldosteronism (PA) was reported to frequently harbor not only\n                        cardiovascular diseases but also some metabolic disorders including\n                        secondary calcium metabolic diseases. Recently, the potential association\n                        between aldosterone producing cells and systemic calcium metabolism has been\n                        proposed. For instance, PA is frequently associated with hypercalciuria or\n                        hypocalcemia, which subsequently stimulates parathyroid hormone (PTH)\n                        secretion. This altered calcium metabolism in PA patients could frequently\n                        result in secondary osteoporosis and fracture in some patients. On the other\n                        hand, extracellular calcium itself directly acts on adrenal cortex and has\n                        been also proposed as an independent regulator of aldosterone biosynthesis\n                        in human adrenals. However, it is also true that both PTH and vitamin D\n                        pathways stimulate endocrine functions of adrenal cortical adenomas to\n                        co-secret both aldosterone and cortisol. Therefore, it has become pivotal to\n                        explore the potential crosstalk between aldosterone and systemic calcium\n                        metabolism. We herein reviewed recent advances in these fields.<\/jats:p>","DOI":"10.1055\/a-1157-0511","type":"journal-article","created":{"date-parts":[[2020,5,13]],"date-time":"2020-05-13T22:45:46Z","timestamp":1589409946000},"page":"448-453","source":"Crossref","is-referenced-by-count":5,"title":["The Effect of Extracellular Calcium Metabolism on Aldosterone\n                    Biosynthesis in Physiological and Pathological Status"],"prefix":"10.1055","volume":"52","author":[{"given":"Xin","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Pathology, Tohoku University Graduate School of Medicine,\n                    Sendai, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuto","family":"Yamazaki","sequence":"additional","affiliation":[{"name":"Department of Pathology, Tohoku University Graduate School of Medicine,\n                    Sendai, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuta","family":"Tezuka","sequence":"additional","affiliation":[{"name":"Division of Clinical Hypertension, Endocrinology and Metabolism, Tohoku\n                    University Graduate School of Medicine, Sendai, Japan"},{"name":"Division of Nephrology, Endocrinology, and Vascular Medicine, Tohoku\n                    University Hospital, Sendai, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kei","family":"Omata","sequence":"additional","affiliation":[{"name":"Division of Clinical Hypertension, Endocrinology and Metabolism, Tohoku\n                    University Graduate School of Medicine, Sendai, Japan"},{"name":"Division of Nephrology, Endocrinology, and Vascular Medicine, Tohoku\n                    University Hospital, Sendai, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshikiyo","family":"Ono","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Endocrinology, and Vascular Medicine, Tohoku\n                    University Hospital, Sendai, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryo","family":"Morimoto","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Endocrinology, and Vascular Medicine, Tohoku\n                    University Hospital, Sendai, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuhiro","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Division of Pathology, Faculty of Medicine, Tohoku Medical and\n                    Pharmaceutical University, Sendai, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fumitoshi","family":"Satoh","sequence":"additional","affiliation":[{"name":"Division of Clinical Hypertension, Endocrinology and Metabolism, Tohoku\n                    University Graduate School of Medicine, Sendai, Japan"},{"name":"Division of Nephrology, Endocrinology, and Vascular Medicine, Tohoku\n                    University Hospital, Sendai, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hironobu","family":"Sasano","sequence":"additional","affiliation":[{"name":"Department of Pathology, Tohoku University Graduate School of Medicine,\n                    Sendai, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2020,5,13]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"2293","DOI":"10.1016\/j.jacc.2006.07.059","article-title":"A prospective study of the prevalence of primary aldosteronism in 1125\n                    hypertensive patients","volume":"48","author":"G P Rossi","year":"2006","journal-title":"J Am Coll Cardiol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1161\/HYPERTENSIONAHA.111.187682","article-title":"The genetics of primary aldosteronism: Chapter two","volume":"59","author":"J W 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Acta"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"e82309","DOI":"10.1371\/journal.pone.0082309","article-title":"Vitamin D receptor, an important transcription factor associated with\n                    aldosterone-producing adenoma","volume":"8","author":"C Bi","year":"2013","journal-title":"PLoS One"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1016\/j.bbrc.2016.01.034","article-title":"Up-regulation of FGF23 release by aldosterone","volume":"470","author":"B Zhang","year":"2016","journal-title":"Biochem Biophys Res Commun"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"4403","DOI":"10.1007\/s00018-018-2885-x","article-title":"Crosstalk between FGF23- and angiotensin II-mediated Ca(2+) signaling in\n                    pathological cardiac hypertrophy","volume":"75","author":"K N Mhatre","year":"2018","journal-title":"Cell Mol Life Sci"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"105434","DOI":"10.1016\/j.jsbmb.2019.105434","article-title":"The crosstalk between aldosterone and calcium metabolism in primary\n                    aldosteronism: A possible calcium metabolism-associated aberrant\n                    \"neoplastic\" steroidogenesis in adrenals","volume":"193","author":"X Gao","year":"2019","journal-title":"J Steroid Biochem Mol Biol"},{"key":"ref32","first-page":"E89","article-title":"Calcium, a \u201cthird messenger\u201d of cAMP-stimulated adrenal steroid\n                    secretion","volume":"248","author":"R J Schiebinger","year":"1985","journal-title":"Am J Physiol"},{"key":"ref33","first-page":"555","article-title":"Relation of Sodium intake to urinary calcium excretion","volume":"1","author":"J S King","year":"1964","journal-title":"Invest Urol"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"F1","DOI":"10.1152\/ajprenal.00143.2009","article-title":"The role of 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Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-1157-0511.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,24]],"date-time":"2022-08-24T00:35:20Z","timestamp":1661301320000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-1157-0511"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5,13]]},"references-count":62,"journal-issue":{"issue":"06","published-online":{"date-parts":[[2020,6,16]]},"published-print":{"date-parts":[[2020,6]]}},"URL":"https:\/\/doi.org\/10.1055\/a-1157-0511","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0018-5043","1439-4286"],"issn-type":[{"value":"0018-5043","type":"print"},{"value":"1439-4286","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,5,13]]}}}