{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T21:42:18Z","timestamp":1772142138399,"version":"3.50.1"},"reference-count":28,"publisher":"Georg Thieme Verlag KG","issue":"11","funder":[{"DOI":"10.13039\/501100003069","name":"Instituto Polit\u00e9cnico Nacional","doi-asserted-by":"crossref","award":["20200493"],"award-info":[{"award-number":["20200493"]}],"id":[{"id":"10.13039\/501100003069","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003069","name":"Instituto Polit\u00e9cnico Nacional","doi-asserted-by":"crossref","award":["20200521"],"award-info":[{"award-number":["20200521"]}],"id":[{"id":"10.13039\/501100003069","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003069","name":"Instituto Polit\u00e9cnico Nacional","doi-asserted-by":"crossref","award":["20201091"],"award-info":[{"award-number":["20201091"]}],"id":[{"id":"10.13039\/501100003069","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003141","name":"Consejo Nacional de Ciencia y Tecnolog\u00eda","doi-asserted-by":"crossref","award":["294402"],"award-info":[{"award-number":["294402"]}],"id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Horm Metab Res"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Thyroid hormone deficiency during crucial stages of development causes congenital\nhypothyroidism. This syndrome alters hypothalamic pathways involved in long-term\nbodyweight regulation as ObRb-STAT3 leptin signaling pathway, which is\nassociated with metabolic syndrome. This study aimed to determine if thyroxine\ntreatment during pregnancy and lactation in hypothyroid mothers avoids, in the\ncongenital hypothyroid offspring, the alterations in metabolic programming\nrelated to metabolic syndrome and the ObRb-STAT3 leptin signaling pathway in\nhypothalamus. Twenty-four virgin female Wistar rats were divided into euthyroid,\nhypothyroid, and hypothyroid with thyroxine treatment (20\n\u03bcg\/kg\/day T4 since pregnancy until\nlactation). The bodyweight and energy intake, insulin resistance, glucose\ntolerance, metabolic and hormonal parameters were determined in offspring at 28\nweeks after birth. Then, the rats were euthanized to obtain adipose tissue\nreserves and hypothalamus to measure the expression of ObRb, STAT3, pSTAT3, and\nSOCS3. Congenital hypothyroidism presented metabolic syndrome such as insulin\nresistance, glucose tolerance, dyslipidemias, an increase in cardiovascular risk\n(Castelli I males:166.67%, females: 173.56%; Castelli II males:\n375.51%, females: 546.67%), and hypothalamic leptin resistance\n(SOCS3, Males: 10.96%, females: 25.85%). Meanwhile, the\nthyroxine treatment in the mothers during pregnancy and lactation prevents the\nmetabolic disturbance. In conclusion, thyroxine treatment during the critical\nperinatal stage for metabolic programming prevents congenital\nhypothyroidism-caused metabolic syndrome and hypothalamic leptin resistance.<\/jats:p>","DOI":"10.1055\/a-1160-9833","type":"journal-article","created":{"date-parts":[[2020,6,19]],"date-time":"2020-06-19T22:57:21Z","timestamp":1592607441000},"page":"815-821","source":"Crossref","is-referenced-by-count":2,"title":["Thyroxine Treatment During the Perinatal Stage Prevents the\nAlterations in the ObRb-STAT3 Leptin Signaling Pathway Caused by Congenital\nHypothyroidism"],"prefix":"10.1055","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3765-2809","authenticated-orcid":false,"given":"Jorge","family":"Tapia-Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Laboratorio de Metabolismo 1, Instituto Polit\u00e9cnico Nacional,\nCiudad de M\u00e9xico, M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edgar","family":"Cano-Europa","sequence":"additional","affiliation":[{"name":"Laboratorio de Metabolismo 1, Instituto Polit\u00e9cnico Nacional,\nCiudad de M\u00e9xico, M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vanessa","family":"Blas-Valdivia","sequence":"additional","affiliation":[{"name":"Laboratorio de Neurobiolog\u00eda, Instituto Polit\u00e9cnico\nNacional, Ciudad de M\u00e9xico, M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margarita","family":"Franco-Col\u00edn","sequence":"additional","affiliation":[{"name":"Laboratorio de Metabolismo 1, Instituto Polit\u00e9cnico Nacional,\nCiudad de M\u00e9xico, M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2020,6,19]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1159\/000363153","article-title":"The role of thyroid hormones for brain development and cognitive function","volume":"26","author":"JF Rovet","year":"2014","journal-title":"Endocr Dev"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.neuroscience.2015.09.070","article-title":"Influence of maternal thyroid hormones during gestation on fetal brain\ndevelopment","volume":"342","author":"N K Moog","year":"2017","journal-title":"Neuroscience"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1586\/17446651.3.5.577","article-title":"Hypothalamic regulation of appetite","volume":"3","author":"K A Simpson","year":"2008","journal-title":"Expert Rev Endocrinol 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Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-1160-9833.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,11,2]],"date-time":"2020-11-02T23:52:32Z","timestamp":1604361152000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-1160-9833"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6,19]]},"references-count":28,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2020,11,2]]},"published-print":{"date-parts":[[2020,11]]}},"URL":"https:\/\/doi.org\/10.1055\/a-1160-9833","relation":{},"ISSN":["0018-5043","1439-4286"],"issn-type":[{"value":"0018-5043","type":"print"},{"value":"1439-4286","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,6,19]]}}}