{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T19:15:10Z","timestamp":1781291710415,"version":"3.54.1"},"reference-count":121,"publisher":"Georg Thieme Verlag KG","issue":"05","funder":[{"name":"Health Research Board of Ireland","award":["R1379"],"award-info":[{"award-number":["R1379"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hamostaseologie"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Preeclampsia complicates up to 8% of pregnancies and is a leading cause of fetomaternal morbidity andmortality. Treatment options are limited, with supportive care and delivery of the placenta representing the cornerstone of current management strategies. Derangements in blood coagulation are wellrecognised in this disorder and appear to favour an increased risk of venous thromboembolism among affected women. This risk appears to be most significant in the postpartum period. The mechanisms underlying this increased thrombosis risk remain to be fully elucidated although increased expression of procoagulant factors, endothelial dysfunction, attenuation of endogenous anticoagulant activity and increased platelet activity have been implicated in the prothrombotic tendency. Preeclampsia is also occasionally complicated by life-threatening haemorrhagic events and current evidence suggests that in some severe manifestations of this disease a coagulopathy with a clinical bleeding tendency may be the predominant haemostatic abnormality. Identifying affected women at significant risk of thrombosis and managing the competing thrombotic and haemorrhagic risks continue to be a significant clinical challenge. Derangements in blood coagulation are also implicated in the pathogenesis of preeclampsia; however, the role of antiplatelet or anticoagulant drugs in the prevention and treatment of this disorder remains a source of considerable debate. In addition, the potential role of specific haemostatic markers as diagnostic or screening tools for preeclampsia has also yet to be determined. Further characterisation of the underlying molecular mechanisms would likely be of major translational relevance and could provide insights into the pathogenesis of this disease as well as the associated haemostatic dysfunction.<\/jats:p>","DOI":"10.1055\/a-1162-3905","type":"journal-article","created":{"date-parts":[[2020,5,25]],"date-time":"2020-05-25T23:11:26Z","timestamp":1590448286000},"page":"594-604","source":"Crossref","is-referenced-by-count":14,"title":["Pathophysiology of the Venous Thromboembolism Risk in Preeclampsia"],"prefix":"10.1055","volume":"40","author":[{"given":"Sarah","family":"Kelliher","sequence":"additional","affiliation":[{"name":"Department of Haematology, Mater Misericordiae University Hospital, Dublin, Ireland"},{"name":"Irish Network for VTE Research (INViTE), Dublin, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia B.","family":"Maguire","sequence":"additional","affiliation":[{"name":"Irish Network for VTE Research (INViTE), Dublin, Ireland"},{"name":"UCD Conway SPHERE Research Group, Dublin, Ireland"},{"name":"School of Biomolecular and Biomedical Science, University College Dublin, Dublin, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulina B.","family":"Szklanna","sequence":"additional","affiliation":[{"name":"UCD Conway SPHERE Research Group, Dublin, Ireland"},{"name":"School of Biomolecular and Biomedical Science, University College Dublin, Dublin, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luisa","family":"Weiss","sequence":"additional","affiliation":[{"name":"UCD Conway SPHERE Research Group, Dublin, Ireland"},{"name":"School of Biomolecular and Biomedical Science, University College Dublin, Dublin, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl","family":"Ewins","sequence":"additional","affiliation":[{"name":"Department of Haematology, Mater Misericordiae University Hospital, Dublin, Ireland"},{"name":"Irish Network for VTE Research (INViTE), Dublin, Ireland"},{"name":"Department of Haematology, Rotunda Hospital, Dublin, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roseann","family":"O'Doherty","sequence":"additional","affiliation":[{"name":"Department of Haematology, Mater Misericordiae University Hospital, Dublin, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Angelov","sequence":"additional","affiliation":[{"name":"Department of Haematology, Mater Misericordiae University Hospital, Dublin, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fionnuala","family":"N\u00ed \u00c1inle","sequence":"additional","affiliation":[{"name":"Department of Haematology, Mater Misericordiae University Hospital, Dublin, Ireland"},{"name":"Irish Network for VTE Research (INViTE), Dublin, Ireland"},{"name":"UCD Conway SPHERE Research Group, Dublin, Ireland"},{"name":"Department of 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Control"},{"issue":"04","key":"ref2","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1515\/jpm-2013-0207","article-title":"Risk factors for pregnancy-associated venous thromboembolism: a review","volume":"42","author":"B Kevane","year":"2014","journal-title":"J Perinat Med"},{"issue":"04","key":"ref3","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1042\/BST20140310","article-title":"Elevated venous thromboembolism risk in preeclampsia: molecular mechanisms and clinical impact","volume":"43","author":"K Egan","year":"2015","journal-title":"Biochem Soc Trans"},{"issue":"01","key":"ref4","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1097\/GRF.0000000000000249","article-title":"Novel therapy for the treatment of early-onset preeclampsia","volume":"60","author":"S Ornaghi","year":"2017","journal-title":"Clin Obstet 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Rolnik","year":"2017","journal-title":"N Engl J Med"},{"issue":"05","key":"ref45","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/j.ajog.2017.12.238","article-title":"Meta-analysis on the effect of aspirin use for prevention of preeclampsia on placental abruption and antepartum hemorrhage","volume":"218","author":"S Roberge","year":"2018","journal-title":"Am J Obstet Gynecol"},{"issue":"10","key":"ref46","first-page":"1","article-title":"Antiplatelet agents for preventing pre-eclampsia and its complications","volume":"2019","author":"L Duley","year":"2019","journal-title":"Cochrane Database Syst Rev"},{"issue":"12","key":"ref47","doi-asserted-by":"crossref","first-page":"e81959","DOI":"10.1371\/journal.pone.0081959","article-title":"Pre-eclampsia increases the risk of postpartum haemorrhage: a nationwide cohort study in the Netherlands","volume":"8","author":"J F von Schmidt auf Altenstadt","year":"2013","journal-title":"PLoS 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Knight","year":"2018","journal-title":"ClinObstetGynecol"},{"issue":"08","key":"ref58","doi-asserted-by":"crossref","first-page":"1531","DOI":"10.1111\/jth.13741","article-title":"Chronic complications of venous thromboembolism","volume":"15","author":"M P Winter","year":"2017","journal-title":"J Thromb Haemost"},{"issue":"11","key":"ref60","doi-asserted-by":"crossref","first-page":"1875","DOI":"10.1111\/jth.14568","article-title":"Prevalence of postpartum venous thromboembolism risk factors in an Irish urban obstetric population","volume":"17","author":"F O'Shaughnessy","year":"2019","journal-title":"J Thromb Haemost"},{"issue":"02","key":"ref61","doi-asserted-by":"crossref","first-page":"233.e1","DOI":"10.1016\/j.ajog.2007.08.041","article-title":"Incidence and risk patterns of venous thromboembolism in pregnancy and puerperium--a register-based case-control study","volume":"198","author":"A F Jacobsen","year":"2008","journal-title":"Am J Obstet 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An important mediator in the pathophysiology of hypertension during pre-eclampsia","volume":"64","author":"B Lamarca","year":"2012","journal-title":"Minerva Ginecol"},{"key":"ref74","doi-asserted-by":"crossref","first-page":"372","DOI":"10.3389\/fphys.2014.00372","article-title":"Endothelial dysfunction and preeclampsia: role of oxidative stress","volume":"5","author":"L C S\u00e1nchez-Aranguren","year":"2014","journal-title":"Front Physiol"},{"issue":"24","key":"ref75","doi-asserted-by":"crossref","first-page":"2856","DOI":"10.1161\/CIRCULATIONAHA.109.853127","article-title":"Preeclampsia, a disease of the maternal endothelium: the role of antiangiogenic factors and implications for later cardiovascular disease","volume":"123","author":"C E Powe","year":"2011","journal-title":"Circulation"},{"issue":"12","key":"ref76","doi-asserted-by":"crossref","first-page":"H1585","DOI":"10.1152\/ajpheart.00096.2013","article-title":"Thrombomodulin and the vascular endothelium: insights into 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markers for pre-eclampsia?","volume":"146","author":"A Rousseau","year":"2009","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"issue":"05","key":"ref80","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1111\/j.1538-7836.2005.01267.x","article-title":"Soluble thrombomodulin activity and soluble thrombomodulin antigen in plasma","volume":"3","author":"A K Ohlin","year":"2005","journal-title":"J Thromb Haemost"},{"issue":"02","key":"ref81","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.thromres.2011.07.023","article-title":"Elevated soluble endothelial cell protein C receptor (sEPCR) levels in women with preeclampsia: a marker of endothelial activation\/damage?","volume":"129","author":"B Saposnik","year":"2012","journal-title":"Thromb Res"},{"issue":"04","key":"ref82","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1161\/ATVBAHA.115.306780","article-title":"Loss of thrombomodulin in placental dysfunction in 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S\u0142omka","year":"2018","journal-title":"Front Immunol"},{"issue":"01","key":"ref86","doi-asserted-by":"crossref","first-page":"1322454","DOI":"10.1080\/20013078.2017.1322454","article-title":"Platelet extracellular vesicles induce a pro-inflammatory smooth muscle cell phenotype","volume":"6","author":"T Vajen","year":"2017","journal-title":"J Extracell Vesicles"},{"key":"ref87","doi-asserted-by":"crossref","first-page":"7","DOI":"10.3389\/fphar.2019.00007","article-title":"Platelet-derived microparticles from obese individuals: characterization of number, size, proteomics, and crosstalk with cancer and endothelial cells","volume":"10","author":"R Grande","year":"2019","journal-title":"Front Pharmacol"},{"issue":"03","key":"ref88","doi-asserted-by":"crossref","first-page":"e1800162","DOI":"10.1002\/prca.201800162","article-title":"The platelet releasate is altered in human pregnancy","volume":"13","author":"P B Szklanna","year":"2019","journal-title":"Proteomics Clin 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Haemost"},{"key":"ref104","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.cca.2012.10.060","article-title":"Fibrinolytic system in preeclampsia","volume":"416","author":"M B Pinheiro","year":"2013","journal-title":"Clin Chim Acta"},{"issue":"03","key":"ref105","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.thromres.2011.11.036","article-title":"Platelets and primary haemostasis","volume":"129","author":"K J Clemetson","year":"2012","journal-title":"Thromb Res"},{"key":"ref107","doi-asserted-by":"crossref","first-page":"147","DOI":"10.3389\/fcell.2016.00147","article-title":"Cancer and thrombosis: the platelet perspective","volume":"4","author":"C K Meikle","year":"2017","journal-title":"Front Cell Dev Biol"},{"issue":"18","key":"ref108","doi-asserted-by":"crossref","first-page":"2759","DOI":"10.1182\/blood-2013-11-462432","article-title":"Emerging roles for platelets as immune and inflammatory cells","volume":"123","author":"C N Morrell","year":"2014","journal-title":"Blood"},{"issue":"03","key":"ref109","first-page":"449","article-title":"The role of platelets in inflammation","volume":"114","author":"M R Thomas","year":"2015","journal-title":"Thromb Haemost"},{"key":"ref110","doi-asserted-by":"crossref","first-page":"71","DOI":"10.3233\/CH-2012-1577","article-title":"Platelets in vascular disease","volume":"53","author":"W H Reinhart","year":"2013","journal-title":"Clin Hemorheol Microcirc"},{"issue":"01","key":"ref111","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1186\/s13045-018-0669-2","article-title":"Role of platelets and platelet receptors in cancer metastasis","volume":"11","author":"M Schlesinger","year":"2018","journal-title":"J Hematol Oncol"},{"issue":"02","key":"ref112","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.htct.2018.08.008","article-title":"A correlation between platelet indices and preeclampsia","volume":"41","author":"N 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