{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T17:58:52Z","timestamp":1760551132518,"version":"3.37.3"},"reference-count":51,"publisher":"Georg Thieme Verlag KG","issue":"06","license":[{"start":{"date-parts":[[2020,5,13]],"date-time":"2020-05-13T00:00:00Z","timestamp":1589328000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Horm Metab Res"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Excess aldosterone is associated with the increased risk of\n                        cardio-\/cerebrovascular events as well as metabolic comorbidities\n                        not only due to its hypertensive effect but also due to its proinflammatory\n                        action. Autonomous cortisol secretion (ACS) in the setting of primary\n                        aldosteronism (PA) is known to worsen cardiovascular outcome and potentially\n                        exhibit immunosuppressive effects. The aim of this study was to determine\n                        the impact of ACS status in patients with PA on kinetics of thyroid\n                        autoantibodies (anti-TPO, anti-TG) pre and post therapy initiation.\n                        Ninety-seven PA patients (43 unilateral, 54 with bilateral PA) from the\n                        database of the German Conn\u2019s Registry were included. Anti-TPO and\n                        anti-TG levels were measured pre and 6\u201312 months post therapeutic\n                        intervention. Patients were assessed for ACS according to their 24- hour\n                        urinary cortisol excretion, late night salivary cortisol and low-dose\n                        dexamethasone suppression test. Abnormal test results in line with ACS were\n                        identified in 74.2% of patients with PA. Following adrenalectomy,\n                        significant increases in anti-TPO levels were observed in patients with at\n                        least one abnormal test (p = 0.049), adrenalectomized patients with\n                        at least two pathological ACS tests (p = 0.015) and adrenalectomized\n                        patients with pathologic dexamethasone suppression tests (p =\n                        0.018). No antibody increases were observed in unilateral PA patients\n                        without ACS and in patients with bilateral PA receiving mineralocorticoid\n                        antagonist therapy (MRA). Our data are in line with an immunosuppressive\n                        effect of mild glucocorticoid excess in PA on thyroid autoantibody titers.\n                        This effect is uncovered by adrenalectomy, but not by MRA treatment.<\/jats:p>","DOI":"10.1055\/a-1164-1944","type":"journal-article","created":{"date-parts":[[2020,5,13]],"date-time":"2020-05-13T22:45:46Z","timestamp":1589409946000},"page":"404-411","source":"Crossref","is-referenced-by-count":7,"title":["The Impact of Glucocorticoid Co-Secretion in Primary Aldosteronism on\n                    Thyroid Autoantibody Titers During the Course of Disease"],"prefix":"10.1055","volume":"52","author":[{"given":"Laura","family":"Handgriff","sequence":"additional","affiliation":[{"name":"Medizinische Klinik und Poliklinik IV, Klinikum der Universit\u00e4t\n                    M\u00fcnchen, Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Adolf","sequence":"additional","affiliation":[{"name":"Medizinische Klinik und Poliklinik IV, Klinikum der Universit\u00e4t\n                    M\u00fcnchen, Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7086-0562","authenticated-orcid":false,"given":"Daniel A.","family":"Heinrich","sequence":"additional","affiliation":[{"name":"Medizinische Klinik und Poliklinik IV, Klinikum der Universit\u00e4t\n                    M\u00fcnchen, Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leah","family":"Braun","sequence":"additional","affiliation":[{"name":"Medizinische Klinik und Poliklinik IV, Klinikum der Universit\u00e4t\n                    M\u00fcnchen, Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nina","family":"Nirschl","sequence":"additional","affiliation":[{"name":"Medizinische Klinik und Poliklinik IV, Klinikum der Universit\u00e4t\n                    M\u00fcnchen, Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisa","family":"Sturm","sequence":"additional","affiliation":[{"name":"Medizinische Klinik und Poliklinik IV, Klinikum der Universit\u00e4t\n                    M\u00fcnchen, Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roland","family":"Ladurner","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Allgemein-, Viszeral- und Transplantationschirurgie,\n                    Klinikum der Universit\u00e4t M\u00fcnchen, Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jens","family":"Ricke","sequence":"additional","affiliation":[{"name":"Klinik und Poliklinik f\u00fcr Radiologie, Klinikum der\n                    Universit\u00e4t M\u00fcnchen, Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Max","family":"Seidensticker","sequence":"additional","affiliation":[{"name":"Klinik und Poliklinik f\u00fcr Radiologie, Klinikum der\n                    Universit\u00e4t M\u00fcnchen, Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Bidlingmaier","sequence":"additional","affiliation":[{"name":"Medizinische Klinik und Poliklinik IV, Klinikum der Universit\u00e4t\n                    M\u00fcnchen, Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Reincke","sequence":"additional","affiliation":[{"name":"Medizinische Klinik und Poliklinik IV, Klinikum der Universit\u00e4t\n                    M\u00fcnchen, Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2020,5,13]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"2293","DOI":"10.1016\/j.jacc.2006.07.059","article-title":"A prospective study of the prevalence of primary aldosteronism in 1125\n                    hypertensive patients","volume":"48","author":"G P Rossi","year":"2006","journal-title":"J Am Coll Cardiol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1889","DOI":"10.1210\/jc.2015-4061","article-title":"The management of primary aldosteronism: Case detection, diagnosis, and\n                    treatment: An Endocrine Society Clinical Practice Guideline","volume":"101","author":"J W Funder","year":"2016","journal-title":"J Clin Endocrinol Metab"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1210\/jc.2008-2116","article-title":"Cardiovascular and cerebrovascular comorbidities of hypokalemic and normokalemic\n                    primary aldosteronism: Results of the German Conn\u2019s Registry","volume":"94","author":"E Born-Frontsberg","year":"2009","journal-title":"J Clin Endocrinol Metab"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1016\/j.jacc.2005.01.015","article-title":"Evidence for an increased rate of cardiovascular events in patients with primary\n                    aldosteronism","volume":"45","author":"P Milliez","year":"2005","journal-title":"J Am Coll Cardiol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1055\/s-0029-1243257","article-title":"Comorbidities in primary aldosteronism","volume":"42","author":"M Quinkler","year":"2010","journal-title":"Horm Metab Res"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.mce.2003.10.009","article-title":"Effect of aldosterone blockade in patients with systolic left ventricular\n                    dysfunction: Implications of the RALES and EPHESUS studies","volume":"217","author":"B Pitt","year":"2004","journal-title":"Mol Cell Endocrinol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"2513","DOI":"10.1210\/jc.2012-3934","article-title":"Aldosterone excess impairs first phase insulin secretion in primary\n                    aldosteronism","volume":"98","author":"E Fischer","year":"2013","journal-title":"J Clin Endocrinol Metab"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"2349","DOI":"10.2337\/dc07-0525","article-title":"Insulin resistance and hyperinsulinemia are related to plasma aldosterone levels\n                    in hypertensive patients","volume":"30","author":"G Colussi","year":"2007","journal-title":"Diabetes Care"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"e124","DOI":"10.1161\/01.RES.0000102404.81461.25","article-title":"Aldosteronism and peripheral blood mononuclear cell activation: A\n                    neuroendocrine-immune interface","volume":"93","author":"R A Ahokas","year":"2003","journal-title":"Circ Res"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1097\/BOR.0b013e3280113d1a","article-title":"Autoimmune thyroid diseases","volume":"19","author":"P Caturegli","year":"2007","journal-title":"Curr Opin Rheumatol"},{"issue":"S 02","key":"ref11","first-page":"205","article-title":"Hashimoto\u2019s Thyroiditis","volume":"1","author":"R Lorini","year":"2003","journal-title":"Pediatr Endocrinol Rev"},{"key":"ref12","first-page":"305","article-title":"The diagnosis and treatment of primary hyperaldosteronism in Germany: Results on\n                    555 patients from the German Conn Registry","volume":"106","author":"C Schirpenbach","year":"2009","journal-title":"Dtsch Arztebl Int"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1055\/a-0672-0836","article-title":"Aldosterone to renin ratio as screening tool in primary aldosteronism","volume":"127","author":"K Schilbach","year":"2019","journal-title":"Exp Clin Endocrinol Diabetes"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1530\/EJE-11-0287","article-title":"Adrenal vein sampling using rapid cortisol assays in primary aldosteronism is\n                    useful in centers with low success rates","volume":"165","author":"M J Betz","year":"2011","journal-title":"Eur J Endocrinol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1111\/eci.12746","article-title":"Accuracy of adrenal imaging and adrenal venous sampling in diagnosing unilateral\n                    primary aldosteronism","volume":"47","author":"R Ladurner","year":"2017","journal-title":"Eur J Clin Invest"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"E1035","DOI":"10.1210\/jc.2013-3789","article-title":"Age below 40 or a recently proposed clinical prediction score cannot bypass\n                    adrenal venous sampling in primary aldosteronism","volume":"99","author":"A Riester","year":"2014","journal-title":"J Clin Endocrinol Metab"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"5658","DOI":"10.1210\/jc.2019-00996","article-title":"Adrenal insufficiency after unilateral adrenalectomy in primary aldosteronism:\n                    Long-term outcome and clinical impact","volume":"104","author":"D A Heinrich","year":"2019","journal-title":"J Clin Endocrinol Metab"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"191","DOI":"10.4049\/jimmunol.0802886","article-title":"Aldosterone promotes autoimmune damage by enhancing Th17-mediated immunity","volume":"184","author":"A A Herrada","year":"2010","journal-title":"J Immunol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"1684","DOI":"10.1097\/HJH.0b013e32834a4c75","article-title":"Aldosterone as a modulator of immunity: Implications in the organ damage","volume":"29","author":"A A Herrada","year":"2011","journal-title":"J Hypertens"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1111\/j.1365-3083.2010.02425.x","article-title":"Differentiation imbalance of Th1\/Th17 in peripheral blood mononuclear\n                    cells might contribute to pathogenesis of Hashimoto\u02bcs thyroiditis","volume":"72","author":"Y Shi","year":"2010","journal-title":"Scand J Immunol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1507\/endocrj.KR-80","article-title":"Aldosterone as a cardiovascular risk hormone","volume":"54","author":"T Yoshimoto","year":"2007","journal-title":"Endocr J"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1046\/j.1365-2249.2003.02249.x","article-title":"Spironolactone inhibits production of proinflammatory cytokines, including\n                    tumour necrosis factor-alpha and interferon-gamma, and has potential in the\n                    treatment of arthritis","volume":"134","author":"K Bendtzen","year":"2003","journal-title":"Clin Exp Immunol"},{"key":"ref23","first-page":"202","volume-title":"MJOH. Hyperaldosteronism and Related Syndromes of Mineralocorticoid Excess","author":"A Munro Neville","year":"1982"},{"key":"ref24","first-page":"195","article-title":"The intercurrent hypertension of primary aldosteronism","volume":"27","author":"E G Biglieri","year":"1970","journal-title":"Circ Res"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1530\/eje.0.1510073","article-title":"Postoperative differentiation between unilateral adrenal adenoma and bilateral\n                    adrenal hyperplasia in primary aldosteronism by mRNA expression of the gene\n                    CYP11B2","volume":"151","author":"U Enberg","year":"2004","journal-title":"Eur J Endocrinol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1111\/pin.12200","article-title":"Dissecting the molecular pathways of primary aldosteronism","volume":"64","author":"Y Nakamura","year":"2014","journal-title":"Pathol Int"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1161\/HYPERTENSIONAHA.118.11086","article-title":"Cellular and genetic causes of idiopathic hyperaldosteronism","volume":"72","author":"K Omata","year":"2018","journal-title":"Hypertension"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1016\/0002-9343(67)90065-4","article-title":"Bilateral adrenal hyperplasia as a cause of primary aldosteronism with\n                    hypertension, hypokalemia and suppressed renin activity","volume":"42","author":"W W Davis","year":"1967","journal-title":"Am J Med"},{"key":"ref29","first-page":"335","article-title":"Primary aldosteronism due to adrenocortical hyperplasia","volume":"271","author":"H Doorenbos","year":"1956","journal-title":"Lancet"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"1828","DOI":"10.1056\/NEJM199812173392507","article-title":"Primary aldosteronism","volume":"339","author":"A Ganguly","year":"1998","journal-title":"N Engl J Med"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.7326\/0003-4819-67-5-1035","article-title":"Primary aldosteronism with suppressed plasma renin activity due to bilateral\n                    nodular adrenocortical hyperplasia","volume":"67","author":"F H Katz","year":"1967","journal-title":"Ann Intern Med"},{"key":"ref32","first-page":"168","article-title":"Secondary aldosteronism and reduced plasma renin in hypertensive disease","volume":"80","author":"J G Ledingham","year":"1967","journal-title":"Trans Assoc Am Physicians"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"1790","DOI":"10.1210\/jc.2013-3282","article-title":"Autoimmune mechanisms activating the angiotensin AT1 receptor in\n                    \u201bprimary\u2019 aldosteronism","volume":"99","author":"D C Kem","year":"2014","journal-title":"J Clin Endocrinol Metab"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1161\/HYPERTENSIONAHA.112.202945","article-title":"Elevation of angiotensin-II type-1-receptor autoantibodies titer in primary\n                    aldosteronism as a result of aldosterone-producing adenoma","volume":"61","author":"G Rossitto","year":"2013","journal-title":"Hypertension"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.jash.2014.10.009","article-title":"Prevalence of angiotensin II type 1 receptor (AT1R)-activating autoantibodies in\n                    primary aldosteronism","volume":"9","author":"H Li","year":"2015","journal-title":"J Am Soc Hypertens"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1210\/jc.2014-3663","article-title":"Update in primary aldosteronism","volume":"100","author":"M Stowasser","year":"2015","journal-title":"J Clin Endocrinol Metab"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1097\/HJH.0000000000002300","article-title":"Risk of new-onset autoimmune diseases in primary aldosteronism: A nation-wide\n                    population-based study","volume":"38","author":"L K Er","year":"2019","journal-title":"J Hypertens"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1161\/HYPERTENSIONAHA.119.13388","article-title":"AT1AA (Angiotensin II Type-1 Receptor Autoantibodies): Cause or consequence of\n                    human primary aldosteronism?","volume":"74","author":"M Piazza","year":"2019","journal-title":"Hypertension"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"1274","DOI":"10.1038\/ajh.2011.144","article-title":"Blood pressure, thyroid-stimulating hormone, and thyroid disease prevalence in\n                    primary aldosteronism and essential hypertension","volume":"24","author":"F Turchi","year":"2011","journal-title":"Am J Hypertens"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1385\/ENDO:22:2:155","article-title":"High prevalence of thyroid ultrasonographic abnormalities in primary\n                    aldosteronism","volume":"22","author":"D Armanini","year":"2003","journal-title":"Endocrine"},{"key":"ref41","first-page":"139","article-title":"Exacerbation of autoimmune hypothyroidism after hemi-hypophysectomy in a patient\n                    with Cushing's disease","volume":"18","author":"K Cioni","year":"1993","journal-title":"Minerva Endocrinol"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1007\/BF03348980","article-title":"Autoimmune thyroid disease after successful treatment of Cushing\u2019s\n                    syndrome","volume":"17","author":"P Colombo","year":"1994","journal-title":"J Endocrinol Invest"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"1708","DOI":"10.1056\/NEJM199006143222404","article-title":"Exacerbation 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J"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1530\/eje.0.1470305","article-title":"Primary thyroid disorders in endogenous Cushing's syndrome","volume":"147","author":"H Niepomniszcze","year":"2002","journal-title":"Eur J Endocrinol"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1046\/j.1365-2265.2000.01018.x","article-title":"Increased prevalence of thyroid autoimmunity in patients successfully treated\n                    for Cushing's disease","volume":"53","author":"A Colao","year":"2000","journal-title":"Clin Endocrinol (Oxf)"}],"container-title":["Hormone and Metabolic Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-1164-1944.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,24]],"date-time":"2022-08-24T00:36:23Z","timestamp":1661301383000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-1164-1944"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5,13]]},"references-count":51,"journal-issue":{"issue":"06","published-online":{"date-parts":[[2020,6,16]]},"published-print":{"date-parts":[[2020,6]]}},"URL":"https:\/\/doi.org\/10.1055\/a-1164-1944","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0018-5043","1439-4286"],"issn-type":[{"type":"print","value":"0018-5043"},{"type":"electronic","value":"1439-4286"}],"subject":[],"published":{"date-parts":[[2020,5,13]]}}}