{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T07:56:36Z","timestamp":1780473396942,"version":"3.54.1"},"reference-count":27,"publisher":"Georg Thieme Verlag KG","issue":"01","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rofo"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:p>\n            Purpose\u2002To investigate if T1 and T2 mapping is able to differentiate between diseased and healthy myocardium in patients with systemic sarcoidosis, and to compare the standard mapping measurement (measurement within the whole myocardium of the midventricular short axis slice, SAX) to a more standardized method measuring relaxation times within the midventricular septum (ConSept).<\/jats:p><jats:p>\n            Materials and Methods\u200224 patients with biopsy-proven extracardiac sarcoidosis and 17 healthy control subjects were prospectively enrolled in this study and underwent CMR imaging at 1.5\u200aT including native T1 and T2 mapping. Patients were divided into patients with (LGE+) and without (LGE\u2013) cardiac sarcoidosis. T1 and T2 relaxation times were compared between patients and controls. Furthermore, the SAX and the ConSept approach were compared regarding differentiation between healthy and diseased myocardium.<\/jats:p><jats:p>\n            Results\u2002T1 and T2 relaxation times were significantly longer in all patients compared with controls using both the SAX and the ConSept approach (p\u200a&lt;\u200a0.05). However, LGE+ and LGE\u2013 patients showed no significant differences in T1 and T2\u00a0relaxation times regardless of the measurement approach used (ConSept\/SAX) (p\u200a&gt;\u200a0.05). Direct comparison of ConSept and SAX T1 mapping showed high conformity in the discrimination between healthy and diseased myocardium (Kappa\u200a=\u200a0.844).<\/jats:p><jats:p>\n            Conclusion\u2002T1 and T2 mapping may not only enable noninvasive recognition of cardiac involvement in patients with systemic sarcoidosis but may also serve as a marker for early cardiac involvement of the disease allowing for timely treatment. ConSept T1 mapping represents an equivalent method for tissue characterization in this population compared to the SAX approach. Further studies including follow-up examinations are necessary to confirm these preliminary results.<\/jats:p><jats:p>\n            Key Points:\u2002<\/jats:p><jats:p>\n            Citation Format\n          <\/jats:p>","DOI":"10.1055\/a-1174-0537","type":"journal-article","created":{"date-parts":[[2020,6,9]],"date-time":"2020-06-09T22:42:56Z","timestamp":1591742576000},"page":"68-76","source":"Crossref","is-referenced-by-count":5,"title":["Myocardial Mapping in Systemic Sarcoidosis: A Comparison of Two Measurement Approaches"],"prefix":"10.1055","volume":"193","author":[{"given":"Darius","family":"Dabir","sequence":"additional","affiliation":[{"name":"Department of Radiology, University Hospital Bonn, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julian","family":"Luetkens","sequence":"additional","affiliation":[{"name":"Department of Radiology, University Hospital Bonn, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Kuetting","sequence":"additional","affiliation":[{"name":"Department of Radiology, University Hospital Bonn, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Nadal","sequence":"additional","affiliation":[{"name":"Department of Medical Biometry, University Hospital Bonn, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans Heinz","family":"Schild","sequence":"additional","affiliation":[{"name":"Department of Radiology, University Hospital Bonn, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Thomas","sequence":"additional","affiliation":[{"name":"Department of Radiology, University Hospital Bonn, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2020,6,9]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1111\/j.1540-8167.2008.01417.x","article-title":"The work-up and management of patients with apparent or subclinical cardiac sarcoidosis: with emphasis on the associated heart rhythm abnormalities","volume":"20","author":"K Soejima","year":"2009","journal-title":"J Cardiovasc Electrophysiol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1161\/CIRCULATIONAHA.114.011522","article-title":"Cardiac sarcoidosis: epidemiology, characteristics, and outcome over 25 years in a nationwide study","volume":"131","author":"R Kandolin","year":"2015","journal-title":"Circulation"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1111\/jce.12401","article-title":"Atrioventricular block as the initial manifestation of cardiac sarcoidosis in 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