{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T05:36:52Z","timestamp":1761197812480},"reference-count":68,"publisher":"Georg Thieme Verlag KG","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Horm Metab Res"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Familial neurohypophyseal diabetes insipidus (FNDI) is an autosomal dominant\nhereditary disorder characterized by severe polydipsia and polyuria that\nusually presents in early childhood. In this study, we describe a new\narginine vasopressin (AVP) gene mutation in an ethnic German family with\nFNDI and provide an overview of disease-associated AVP-gene mutations that\nare already described in literature. Three members of a German family with\nneurohypophyseal diabetes insipidus were studied. Isolated DNA from\nperipheral blood samples was used for mutation analysis by sequencing the\nwhole coding region of AVP-NPII gene. Furthermore, we searched the\nelectronic databases MEDLINE (Pubmed) as well as HGMD, LOVD-ClinVar, db-SNP\nand genomAD in order to compare our cases to that of other patients with\nFNDI. Genetic analysis of the patients revealed a novel heterozygote\nmissense mutation in exon 2 of the AVP gene (c.274T&gt;G), which has\nnot yet been described in literature. We identified reports of more than 90\ndisease-associated mutations in the AVP gene in literature. The novel\nmutation of the AVP gene seems to cause FNDI in the presented German family.\nSimilar to our newly detected mutation, most mutations causing FNDI are\nfound in exon 2 of the AVP gene coding for neurophysin II. Clinically, it is\nimportant to think of FNDI in young children presenting with polydipsia and\npolyuria.<\/jats:p>","DOI":"10.1055\/a-1175-1307","type":"journal-article","created":{"date-parts":[[2020,7,6]],"date-time":"2020-07-06T23:03:57Z","timestamp":1594076637000},"page":"796-802","source":"Crossref","is-referenced-by-count":3,"title":["Central Diabetes Insipidus Caused by Arginine Vasopressin Gene Mutation: Report of a Novel Mutation and Review of Literature"],"prefix":"10.1055","volume":"52","author":[{"given":"Lara L.I.","family":"Feldkamp","sequence":"additional","affiliation":[{"name":"Endocrinology in Charlottenburg, Berlin, Germany"},{"name":"Charit\u00e9 Universit\u00e4tsmedizin Berlin, Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elke","family":"Kaminsky","sequence":"additional","affiliation":[{"name":"Laboratory for Molecular Genetics, Hamburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tina","family":"Kienitz","sequence":"additional","affiliation":[{"name":"Endocrinology in Charlottenburg, Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcus","family":"Quinkler","sequence":"additional","affiliation":[{"name":"Endocrinology in Charlottenburg, Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2020,7,6]]},"reference":[{"key":"ref1","first-page":"544","volume-title":"Endocrinology","author":"L J DeGroot","year":"2006"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1007\/s12020-012-9606-2","article-title":"Clinical and molecular analysis of a Chinese family with autosomal dominant\nneurohypophyseal diabetes insipidus associated with a novel missense mutation in\nthe vasopressin-neurophysin II gene","volume":"42","author":"Y Luo","year":"2012","journal-title":"Endocrine"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1038\/295299a0","article-title":"Nucleotide sequence of cloned cDNA encoding bovine arginine\nvasopressin-neurophysin II precursor","volume":"295","author":"H Land","year":"1982","journal-title":"Nature"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1038\/sj.ejhg.5201086","article-title":"Six novel mutations in the arginine vasopressin gene in 15 kindreds with\nautosomal dominant familial neurohypophyseal diabetes insipidus give further\ninsight into the pathogenesis","volume":"12","author":"J H Christensen","year":"2004","journal-title":"Eur J Hum Genet"},{"key":"ref5","first-page":"349","article-title":"Central diabetes insipidus","volume":"78","author":"H Arima","year":"2016","journal-title":"Nagoya J Med Sci"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"3351","DOI":"10.1210\/jcem.87.7.8677","article-title":"Autosomal dominant neurohypophyseal diabetes insipidus due to substitution of\nhistidine for tyrosine (2) in the vasopressin moiety of the hormone\nprecursor","volume":"87","author":"S Rittig","year":"2002","journal-title":"J Clin Endocrinol Metab"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1093\/hmg\/8.7.1303","article-title":"Autosomal recessive familial neurohypophyseal diabetes insipidus with continued\nsecretion of mutant weakly active vasopressin","volume":"8","author":"M D Willcutts","year":"1999","journal-title":"Hum Mol Genet"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1530\/EJE-10-0823","article-title":"Growth retardation in untreated autosomal dominant familial neurohypophyseal\ndiabetes insipidus caused by one recurring and two novel mutations in the\nvasopressin-neurophysin II gene","volume":"164","author":"C Brachet","year":"2011","journal-title":"Eur J Endocrinol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1002\/j.1460-2075.1992.tb05022.x","article-title":"A missense mutation in the vasopressin-neurophysin precursor gene cosegregates\nwith human autosomal dominant neurohypophyseal diabetes insipidus","volume":"11","author":"U Bahnsen","year":"1992","journal-title":"EMBO J"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"3351","DOI":"10.1210\/jcem.84.9.5979","article-title":"Molecular analysis in familial neurohypophyseal diabetes insipidus: early\ndiagnosis of an asymptomatic carrier","volume":"84","author":"B Calvo","year":"1999","journal-title":"J Clin Endocrinol Metab"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1210\/jcem.83.2.4571","article-title":"Identification of mutations of the arginine vasopressin-neurophysin II gene in\ntwo kindreds with familial central diabetes insipidus","volume":"83","author":"C Heppner","year":"1998","journal-title":"J Clin Endocrinol Metab"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1007\/s11102-010-0230-y","article-title":"Polyuria and polydipsia in a young child: diagnostic considerations and\nidentification of novel mutation causing familial neurohypophyseal diabetes\ninsipidus","volume":"15","author":"M D Stephen","year":"2012","journal-title":"Pituitary"},{"key":"ref13","first-page":"3643","article-title":"Autosomal dominant neurohypophyseal diabetes insipidus associated with a\nmissense mutation encoding Gly23-->Val in neurophysin II","volume":"82","author":"P C Gagliardi","year":"1997","journal-title":"J Clin Endocrinol Metab"},{"key":"ref14","first-page":"421","article-title":"A de novo mutation in the coding sequence for neurophysin-II\n[Pro24-->Leu] is associated with onset and transmission of autosomal\ndominant neurohypophyseal diabetes insipidus","volume":"79","author":"D R Repaske","year":"1994","journal-title":"J Clin Endocrinol Metab"},{"key":"ref15","first-page":"143","article-title":"A new missense mutation of the vasopressin-neurophysin II gene in a family with\nneurohypophyseal diabetes insipidus","volume":"60","author":"M T Wolf","year":"2003","journal-title":"Horm Res"},{"key":"ref16","first-page":"239","article-title":"A novel arginine vasopressin-neurophysin II mutation causes autosomal dominant\nneurohypophyseal diabetes insipidus and morphologic pituitary changes","volume":"53","author":"N Skordis","year":"2000","journal-title":"Horm Res"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/S1096-7192(02)00118-X","article-title":"A missense mutation encoding Cys73Phe in neurophysin II is associated with\nautosomal dominant neurohypophyseal diabetes insipidus","volume":"77","author":"J Santiprabhob","year":"2002","journal-title":"Mol Genet Metab"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1507\/endocrj.51.551","article-title":"Novel mutant vasopressin-neurophysin II gene associated with familial\nneurohypophyseal diabetes insipidus","volume":"51","author":"M Miyakoshi","year":"2004","journal-title":"Endocr J"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1111\/j.1365-2265.2012.04417.x","article-title":"Late-onset familial neurohypophyseal diabetes insipidus due to a novel mutation\nin the AVP gene","volume":"77","author":"J Jendle","year":"2012","journal-title":"Clin Endocrinol (Oxf)"},{"key":"ref20","first-page":"3958","article-title":"Two novel mutations of the vasopressin gene associated with familial diabetes\ninsipidus and identification of an asymptomatic carrier infant","volume":"83","author":"F D Grant","year":"1998","journal-title":"J Clin Endocrinol Metab"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1172\/JCI115052","article-title":"A single base substitution in the coding region for neurophysin II associated\nwith familial central diabetes insipidus","volume":"87","author":"M Ito","year":"1991","journal-title":"J Clin Invest"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1590\/S0004-27302008000800011","article-title":"Autosomal dominant familial neurohypophyseal diabetes insipidus caused by a\nnovel mutation in arginine-vasopressin gene in a Brazilian family","volume":"52","author":"M E Melo","year":"2008","journal-title":"Arq Bras Endocrinol Metabol"},{"key":"ref23","first-page":"1352","article-title":"Two novel mutations in the coding region for neurophysin-II associated with\nfamilial central diabetes insipidus","volume":"80","author":"H Nagasaki","year":"1995","journal-title":"J Clin Endocrinol Metab"},{"key":"ref24","first-page":"1787","article-title":"A new type of familial central diabetes insipidus caused by a single base\nsubstitution in the neurophysin II coding region of the vasopressin gene","volume":"81","author":"Y Ueta","year":"1996","journal-title":"J Clin Endocrinol Metab"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1006\/mgme.1999.2825","article-title":"A novel mutation [R97C] in the neurophysin moiety of\nprepro-vasopressin-neurophysin II associated with autosomal-dominant\nneurohypophyseal diabetes insipidus","volume":"67","author":"J Rutishauser","year":"1999","journal-title":"Mol Genet Metab"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1530\/eje.0.1510605","article-title":"Identification of a novel mutation in the arginine vasopressin-neurophysin II\ngene affecting the sixth intrachain disulfide bridge of the neurophysin II\nmoiety","volume":"151","author":"S Baglioni","year":"2004","journal-title":"Eur J Endocrinol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1006\/mgme.2000.3117","article-title":"A missense mutation encoding cys (67) --> gly in neurophysin ii is\nassociated with early onset autosomal dominant neurohypophyseal diabetes\ninsipidus","volume":"72","author":"L A DiMeglio","year":"2001","journal-title":"Mol Genet Metab"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1046\/j.1365-2265.2003.01834.x","article-title":"Progressive decline of vasopressin secretion in familial autosomal dominant\nneurohypophyseal diabetes insipidus presenting a novel mutation in the\nvasopressin-neurophysin II gene","volume":"59","author":"P C Elias","year":"2003","journal-title":"Clin Endocrinol (Oxf)"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1530\/eje.0.1460649","article-title":"Clinical and molecular analysis of three families with autosomal dominant\nneurohypophyseal diabetes insipidus associated with a novel and recurrent\nmutations in the vasopressin-neurophysin II gene","volume":"146","author":"J Rutishauser","year":"2002","journal-title":"Eur J Endocrinol"},{"key":"ref30","first-page":"229","article-title":"Familial neurohypophyseal diabetes insipidus associated with a novel mutation in\nthe vasopressin-neurophysin II gene","volume":"5","author":"H Fujii","year":"2000","journal-title":"Int J Mol Med"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1210\/jcem.83.3.4658","article-title":"Identification of a novel nonsense mutation and a missense substitution in the\nvasopressin-neurophysin II gene in two Spanish kindreds with familial\nneurohypophyseal diabetes insipidus","volume":"83","author":"B Calvo","year":"1998","journal-title":"J Clin Endocrinol Metab"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1055\/s-2002-29091","article-title":"Identification of a novel mutation in the arginine vasopressin-neurophysin II\ngene in familial central diabetes insipidus","volume":"110","author":"C Bullmann","year":"2002","journal-title":"Exp Clin Endocrinol Diabetes"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1530\/EJE-11-0048","article-title":"Familial neurohypophyseal diabetes insipidus due to a novel mutation in the\narginine vasopressin-neurophysin II gene","volume":"165","author":"M de Fost","year":"2011","journal-title":"Eur J Endocrinol"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"1963","DOI":"10.1210\/jc.2003-031542","article-title":"A novel mutation in the preprovasopressin gene identified in a kindred with\nautosomal dominant neurohypophyseal diabetes insipidus","volume":"89","author":"J T Wahlstrom","year":"2004","journal-title":"J Clin Endocrinol Metab"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1530\/eje.0.1450439","article-title":"Autosomal dominant neurohypophyseal diabetes insipidus in a Swiss family, caused\nby a novel mutation (C59Delta\/A60W) in the neurophysin moiety of\nprepro-vasopressin-neurophysin II (AVP-NP II)","volume":"145","author":"C E Fluck","year":"2001","journal-title":"Eur J Endocrinol"},{"key":"ref36","first-page":"600","article-title":"Glu-47, which forms a salt bridge between neurophysin-II and arginine\nvasopressin, is deleted in patients with familial central diabetes\ninsipidus","volume":"77","author":"H Yuasa","year":"1993","journal-title":"J Clin Endocrinol Metab"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/j.ymgme.2005.05.009","article-title":"A novel splice site mutation of the arginine vasopressin-neurophysin II gene\nidentified in a kindred with autosomal dominant familial neurohypophyseal\ndiabetes insipidus","volume":"86","author":"H J Tae","year":"2005","journal-title":"Mol Genet Metab"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1111\/j.1399-0004.2011.01833.x","article-title":"A novel deletion partly removing the AVP gene causes autosomal recessive\ninheritance of early-onset neurohypophyseal diabetes insipidus","volume":"83","author":"J H Christensen","year":"2013","journal-title":"Clin Genet"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1055\/s-0033-1354388","article-title":"Dilatative uropathy as a manifestation of neurohypophyseal diabetes insipidus\ndue to a novel mutation in the arginine vasopressin-neurophysin-II gene","volume":"225","author":"V Lindenthal","year":"2013","journal-title":"Klin Padiatr"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1530\/EJE-19-0299","article-title":"Familial neurohypophyseal diabetes insipidus in 13 kindreds and 2 novel\nmutations in the vasopressin gene","volume":"181","author":"G Patti","year":"2019","journal-title":"Eur J Endocrinol"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1007\/s40618-015-0357-9","article-title":"A novel AVP gene mutation in a Turkish family with neurohypophyseal diabetes\ninsipidus","volume":"39","author":"M Ilhan","year":"2016","journal-title":"J Endocrinol Invest"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1007\/s11102-012-0392-x","article-title":"A novel variation in the AVP gene resulting in familial neurohypophyseal\ndiabetes insipidus in a large Italian kindred","volume":"16","author":"C Birkegaard","year":"2013","journal-title":"Pituitary"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.3892\/ijmm.2016.2703","article-title":"Identification of five novel arginine vasopressin gene mutations in patients\nwith familial neurohypophyseal diabetes insipidus","volume":"38","author":"D Tian","year":"2016","journal-title":"Int J Mol Med"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1007\/BF03345549","article-title":"A novel heterozygous missense mutation in the vasopressin moiety is identified\nin a Japanese person with neurohypophyseal diabetes insipidus","volume":"29","author":"H Kobayashi","year":"2006","journal-title":"J Endocrinol Invest"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1111\/j.1365-2265.2008.03303.x","article-title":"Utility of AVP gene testing in familial neurohypophyseal diabetes insipidus","volume":"69","author":"S Chitturi","year":"2008","journal-title":"Clin Endocrinol (Oxf)"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1007\/s00431-016-2759-x","article-title":"Two novel mutations in seven Czech and Slovak kindreds with familial\nneurohypophyseal diabetes insipidus-benefit of genetic testing","volume":"175","author":"G Hrckova","year":"2016","journal-title":"Eur J Pediatr"},{"key":"ref47","first-page":"12","article-title":"Mutation of Glu78 of the AVP-NPII gene impairs neurophysin as a carrier protein\nfor arginine vasopressin in a family with neurohypophyseal diabetes\ninsipidus","volume":"38","author":"Y W Lee","year":"2008","journal-title":"Ann Clin Lab Sci"},{"key":"ref48","first-page":"105","article-title":"Forty-one individuals with mutations in the AVP-NPII gene associated with\nfamilial neurohypophyseal diabetes insipidus","author":"A Garcia-Castano","year":"2020","journal-title":"J Clin Endocrinol Metab"},{"key":"ref49","first-page":"107","article-title":"Identification of 13 new mutations in the vasopressin-neurophysin II gene in 17\nkindreds with familial autosomal dominant neurohypophyseal diabetes\ninsipidus","volume":"58","author":"S Rittig","year":"1996","journal-title":"Am J Hum Genet"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"2836","DOI":"10.1681\/ASN.2005040371","article-title":"Molecular biology of hereditary diabetes insipidus","volume":"16","author":"T M Fujiwara","year":"2005","journal-title":"J Am Soc Nephrol"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1159\/000477246","article-title":"The novel Ser18del AVP variant causes inherited neurohypophyseal diabetes\ninsipidus by mechanisms shared with other signal peptide variants","volume":"106","author":"L B Toustrup","year":"2018","journal-title":"Neuroendocrinology"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"4605","DOI":"10.1210\/en.2014-1385","article-title":"Diabetes insipidus: celebrating a century of vasopressin therapy","volume":"155","author":"S Qureshi","year":"2014","journal-title":"Endocrinology"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/0022-2836(75)90213-2","article-title":"A rapid method for determining sequences in DNA by primed synthesis with DNA\npolymerase","volume":"94","author":"F Sanger","year":"1975","journal-title":"J Mol Biol"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1530\/EJE-14-0942","article-title":"Early-onset central diabetes insipidus is associated with de novo arginine\nvasopressin-neurophysin II or Wolfram syndrome 1 gene mutations","volume":"172","author":"S Perrotta","year":"2015","journal-title":"Eur J Endocrinol"},{"key":"ref55","first-page":"784","article-title":"Gene symbol: AVP. Disease: Diabetes insipidus, neurohypophyseal. Accession\n#Hm0561","volume":"Feb 118(6)","author":"A P Abbes","year":"2006","journal-title":"Hum Genet"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.beem.2016.02.008","article-title":"Genetic forms of neurohypophyseal diabetes insipidus","volume":"30","author":"J Rutishauser","year":"2016","journal-title":"Best Pract Res Clin Endocrinol Metab"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"3994","DOI":"10.1242\/jcs.051136","article-title":"Dominant pro-vasopressin mutants that cause diabetes insipidus form\ndisulfide-linked fibrillar aggregates in the endoplasmic reticulum","volume":"122 (Pt 21)","author":"J Birk","year":"2009","journal-title":"J Cell Sci"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.semnephrol.2006.03.003","article-title":"Familial neurohypophyseal diabetes insipidus\u2013an update","volume":"26","author":"J H Christensen","year":"2006","journal-title":"Semin Nephrol"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"110653","DOI":"10.1016\/j.mce.2019.110653","article-title":"Role of protein aggregation and degradation in autosomal dominant\nneurohypophyseal diabetes insipidus","volume":"501","author":"M Spiess","year":"2019","journal-title":"Mol Cell Endocrinol"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1007\/s00441-018-2872-4","article-title":"A novel mechanism of autophagy-associated cell death of vasopressin neurons in\nfamilial neurohypophysial diabetes insipidus","volume":"375","author":"D Hagiwara","year":"2019","journal-title":"Cell Tissue Res"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1210\/en.2014-1812","article-title":"Aquaporins, vasopressin, and aging: current perspectives","volume":"156","author":"G Tamma","year":"2015","journal-title":"Endocrinology"},{"key":"ref62","first-page":"51","article-title":"Heterogeneity in clinical manifestation of autosomal dominant neurohypophyseal\ndiabetes insipidus caused by a mutation encoding Ala-1-->Val in the\nsignal peptide of the arginine vasopressin\/neurophysin\nII\/copeptin precursor","volume":"82","author":"D R Repaske","year":"1997","journal-title":"J Clin Endocrinol Metab"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1111\/j.1365-2265.2005.02327.x","article-title":"Expression of three different mutations in the arginine vasopressin gene\nsuggests genotype-phenotype correlation in familial neurohypophyseal diabetes\ninsipidus kindreds","volume":"63","author":"C Siggaard","year":"2005","journal-title":"Clin Endocrinol (Oxf)"},{"key":"ref64","first-page":"E394","article-title":"Chronic stress enhances vasopressin but not corticotropin-releasing factor\nsecretion during hypoglycemia","volume":"263","author":"D C De Goeij","year":"1992","journal-title":"Am J Physiol"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"1716","DOI":"10.1172\/JCI114626","article-title":"Insulin-induced hypoglycemia stimulates corticotropin-releasing factor and\narginine vasopressin secretion into hypophysial portal blood of conscious,\nunrestrained rams","volume":"85","author":"A Caraty","year":"1990","journal-title":"J Clin Invest"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1159\/000126185","article-title":"Hypoglycemia-induced arginine vasopressin and oxytocin release is mediated by\nglucoreceptors located inside the blood-brain barrier","volume":"55","author":"P Chiodera","year":"1992","journal-title":"Neuroendocrinology"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1677\/joe.0.1530401","article-title":"Effect of insulin-induced hypoglycaemia on secretion patterns and rates of\ncorticotrophin-releasing hormone, arginine vasopressin and adrenocorticotrophin\nin horses","volume":"153","author":"S L Alexander","year":"1997","journal-title":"J Endocrinol"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1111\/cen.12608","article-title":"Gender-specific co-activation of arginine vasopressin and the\nhypothalamic-pituitary-adrenal axis during stress","volume":"82","author":"S Kacheva","year":"2015","journal-title":"Clin Endocrinol (Oxf)"}],"container-title":["Hormone and Metabolic 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