{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T04:56:34Z","timestamp":1790139394471,"version":"4.0.1"},"reference-count":28,"publisher":"Georg Thieme Verlag KG","issue":"09","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Horm Metab Res"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Endothelial dysfunction is the important early step in the development of\n                    atherosclerosis. Hypothyroidism caused by Hashimoto\u2019s thyroiditis and\n                    other thyroid disease is one of the risk factors of endothelial dysfunction. The\n                    present study tried to investigate the endothelial function and its associated\n                    factors in Hashimoto thyroiditis with euthyroidism. A total of 95 newly\n                    diagnosed Hashimoto\u2019s thyroiditis patients with euthyroidism and 45\n                    healthy controls were studied. Hashimoto\u2019s patients were divided into 3\n                    subgroups namely, single thyroglobulin antibody (TGAb) positive subgroup, single\n                    thyroid peroxidase antibody (TPOAb) positive subgroup, and both TGAb and TPOAb\n                    positive subgroup. Endothelial function was tested by the reactive hyperemia\n                    index (RHI). Hashimoto\u2019s thyroiditis patients had lower RHI than healthy\n                    controls (1.73\u00b10.42 vs 1.96\u00b10.51, p&lt;0.05).\n                    Hashimoto\u2019s thyroiditis with single TGAb positive patients had higher\n                    RHI than single TPOAb positive (1.98\u00b10.57 vs. 1.69\u00b10.33,\n                    p&lt;0.05) and TGAB + TPOAb positive patients (1.98\u00b10.57\n                    vs. 1.68\u00b10.42, p&lt;0.05). RHI were negatively associated with\n                    total cholesterol (TC, r=\u22120.215, p&lt;0.05), low density\n                    lipoprotein cholesterol (LDL-C, r=\u22120.268, p&lt;0.05),\n                    triglyceride (TG, r=\u22120.192, p&lt;0.05), and TPOAb\n                    (r=\u22120.288, p&lt;0.05). In the regression analysis, LDL-C\n                    (\u03b2=\u22120.146, p&lt;0.05), TG\n                    (\u03b2=\u22120.034, p&lt;0.05) and TPOAb\n                    (\u03b2=\u22120.001, p&lt;0.05) were independently associated\n                    with RHI. Hashimoto\u2019s patients had poor endothelial function. TPOAb\n                    levels were negatively associated with endothelial function.<\/jats:p>","DOI":"10.1055\/a-1178-5882","type":"journal-article","created":{"date-parts":[[2020,6,15]],"date-time":"2020-06-15T22:50:36Z","timestamp":1592261436000},"page":"642-646","source":"Crossref","is-referenced-by-count":14,"title":["The Relationship Between the Impairment of Endothelial Function and\n                    Thyroid Antibodies in Hashimoto\u2019s Thyroiditis Patients with\n                    Euthyroidism"],"prefix":"10.1055","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3124-7132","authenticated-orcid":false,"given":"Yanjin","family":"Hu","sequence":"first","affiliation":[{"name":"Department of Endocrinology, Beijing Chao-yang Hospital,\n                    Capital Medical University. Beijing P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi","family":"Yao","sequence":"first","affiliation":[{"name":"Department of Endocrinology, Beijing Chao-yang Hospital,\n                    Capital Medical University. Beijing P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Beijing Chao-yang Hospital,\n                    Capital Medical University. Beijing P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2020,6,15]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1056\/NEJMoa1406656","article-title":"Demographic and epidemiologic drivers of global cardiovascular mortality","volume":"372","author":"G A Roth","year":"2015","journal-title":"N Engl J Med"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1038\/35025203","article-title":"Atherosclerosis","volume":"407","author":"A J Lusis","year":"2000","journal-title":"Nature"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1161\/CIRCRESAHA.115.306301","article-title":"Endothelial cell dysfunction and the pathobiology of atherosclerosis","volume":"118","author":"M A Gimbrone","year":"2016","journal-title":"Circ Res"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.autrev.2014.10.016","article-title":"Autoimmune 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Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-1178-5882.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,10]],"date-time":"2020-09-10T22:37:20Z","timestamp":1599777440000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-1178-5882"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6,15]]},"references-count":28,"journal-issue":{"issue":"09","published-online":{"date-parts":[[2020,9,10]]},"published-print":{"date-parts":[[2020,9]]}},"URL":"https:\/\/doi.org\/10.1055\/a-1178-5882","relation":{},"ISSN":["0018-5043","1439-4286"],"issn-type":[{"value":"0018-5043","type":"print"},{"value":"1439-4286","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,6,15]]}}}