{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T16:41:33Z","timestamp":1792600893259,"version":"4.5.0"},"reference-count":0,"publisher":"Georg Thieme Verlag KG","issue":"07","funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81770822"],"award-info":[{"award-number":["81770822"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Horm Metab Res"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Non-alcoholic fatty liver disease (NAFLD) is currently the most common cause of\n                    chronic liver disease. However, the treatment is limited. The aim of this\n                    meta-analysis was to evaluate the effects and safety of sitagliptin, a selective\n                    inhibitor of dipeptidyl peptidase-4 (DPP-4I), in treating NAFLD. Studies were\n                    sourced from electronic databases including PubMed, CENTRAL (Cochrane Controlled\n                    Trials Register), Embase, Medline, Web of Science, Clinical Trials, and CNKI to\n                    identify all randomized controlled clinical trials (RCTs) and non-RCTs in adult\n                    patients with NAFLD. Key outcomes were changes in serum levels of liver enzymes\n                    and improvement in hepatic histology and fat content measured by imaging or\n                    liver biopsy. Stata14.0 and RevMan5.3 were used for the meta-analysis. Seven\n                    studies with 269 NAFLD patients were included. Compared to the control group,\n                    sitagliptin treatment improved serum gamma-glutamyl transpeptidase (GGT) levels\n                    in the RCT subgroup (SMD = 0.79, 95% CI: 0.01\u20131.58).\n                    However, there was no significant improvement in serum alanine aminotransferase\n                    (ALT) or aspartate aminotransferase (AST) levels following sitagliptin\n                    treatment. Four of the included studies performed liver imaging, but sitagliptin\n                    treatment did not result in a significant reduction in liver fat content. Only\n                    five participants developed sitagliptin-related gastrointestinal discomfort. Our\n                    study suggests that sitagliptin effects individuals with NAFLD by improving\n                    serum GGT. Although sitagliptin is safe and well tolerated in NAFLD patients, it\n                    exerts no beneficial effects on liver transaminase and liver fat content in\n                    these patients.<\/jats:p>","DOI":"10.1055\/a-1186-0841","type":"journal-article","created":{"date-parts":[[2020,6,19]],"date-time":"2020-06-19T22:57:21Z","timestamp":1592607441000},"page":"517-526","source":"Crossref","is-referenced-by-count":11,"title":["Effects and Safety of Sitagliptin in Non-Alcoholic Fatty Liver\n                    Disease: A Systematic Review and Meta-Analysis"],"prefix":"10.1055","volume":"52","author":[{"given":"Yuhan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabology, Shandong University, Jinan,\n                    China"},{"name":"Laboratory of Endocrinology, The First Affiliated Hospital of Shandong\n                    First Medical University, Jinan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tian","family":"Cai","sequence":"additional","affiliation":[{"name":"Division of Traditional Chinese Medicine, Tai\u2019an Hospital of\n                    Traditional Chinese Medicine, Tai\u2019an, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junyu","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabology, Shandong University, Jinan,\n                    China"},{"name":"Department of Endocrinology and Metabology, The First Affiliated\n                    Hospital of Shandong First Medical University, Jinan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Congcong","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Affiliated Hospital of Shandong University\n                    of Traditional Chinese Medicine, Jinan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinming","family":"Yao","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabology, Shandong University, Jinan,\n                    China"},{"name":"Department of Endocrinology and Metabology, The First Affiliated\n                    Hospital of Shandong First Medical University, Jinan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Gao","sequence":"additional","affiliation":[{"name":"Laboratory of Endocrinology, The First Affiliated Hospital of Shandong\n                    First Medical University, Jinan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianjun","family":"Dong","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Qilu Hospital of Shandong University, Jinan,\n                    China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Liao","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabology, Shandong University, Jinan,\n                    China"},{"name":"Department of Endocrinology and Metabology, The First Affiliated\n                    Hospital of Shandong First Medical University, Jinan, China"},{"name":"Department of Endocrinology, Affiliated Hospital of Shandong University\n                    of Traditional Chinese Medicine, Jinan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2020,6,19]]},"container-title":["Hormone and Metabolic Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-1186-0841.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,7,17]],"date-time":"2020-07-17T22:35:58Z","timestamp":1595025358000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-1186-0841"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6,19]]},"references-count":0,"journal-issue":{"issue":"07","published-online":{"date-parts":[[2020,7,17]]},"published-print":{"date-parts":[[2020,7]]}},"URL":"https:\/\/doi.org\/10.1055\/a-1186-0841","relation":{},"ISSN":["0018-5043","1439-4286"],"issn-type":[{"value":"0018-5043","type":"print"},{"value":"1439-4286","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,6,19]]}}}