{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T03:35:02Z","timestamp":1768448102417,"version":"3.49.0"},"reference-count":17,"publisher":"Georg Thieme Verlag KG","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Laryngorhinootologie"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title><jats:p>\n          Hintergrund\u2002Metamizol war 2018 das am zweith\u00e4ufigsten verordnete Medikament in Deutschland trotz des bekannten Risikos einer Agranulozytose und der strengen Indikationsstellung. 25\u200a% der Verordnungen sind laut Stammschulte et\u00a0al. Off-Label-Use. Obwohl eine Blutbildkontrolle in der Fachinformation ausdr\u00fccklich empfohlen wird, findet diese seitens der Mehrheit der Metamizol-verschreibenden \u00c4rzte nicht routinem\u00e4\u00dfig statt.<\/jats:p><jats:p>\n          Material und Methoden\u2002Retrospektive Untersuchung von 8\u00a0F\u00e4llen von Agranulozytose nach Metamizol-Einnahme im HNO-Universit\u00e4tsklinikum Erlangen in den Jahren 2016\u20132020. Es handelte sich um 5 M\u00e4nner und 3 Frauen. Das Durchschnittsalter bei Diagnosestellung lag bei 52,4 Jahren (\u00b1\u200a25,6).<\/jats:p><jats:p>\n          Ergebnisse\u2002Agranulozytose nach Metamizol-Einnahme ist eine schwerwiegende unerw\u00fcnschte Nebenwirkung, die prinzipiell Patienten jeden Alters betreffen kann. Oft f\u00fchrt erst eine Symptomatik in Form von Fieber, Dysphagie und Tonsillitis, meist in Kombination mit Abszessen im Kopf-Hals-Bereich, zur Erkennung einer Metamizol-induzierten Agranulozytose. Eine Agranulozytose erfordert teilweise radikal-chirurgische und intensivstation\u00e4re Ma\u00dfnahmen und kann zur Sepsis mit Organversagen oder sogar zum Tod f\u00fchren.<\/jats:p><jats:p>\n          Schlussfolgerungen\u2002Die beschriebenen Patientenf\u00e4lle zeigen, dass Agranulozytose eine gef\u00e4hrliche bis teilweise sogar t\u00f6dliche Nebenwirkung nach Metamizol-Einnahme darstellt. Auch wenn das Risiko einer Agranulozytose mit der Dauer der Anwendung anzusteigen scheint, sollten im Sinne der Patientensicherheit eine entsprechende Patientenaufkl\u00e4rung und die Dokumentation einer bereits einmaligen intraoperativen Gabe im Entlassbrief erfolgen. So k\u00f6nnte eine Agranulozytose fr\u00fcher erkannt und schwere Komplikationen bis hin zum Tod vermieden werden.<\/jats:p>","DOI":"10.1055\/a-1190-4445","type":"journal-article","created":{"date-parts":[[2020,6,26]],"date-time":"2020-06-26T01:23:55Z","timestamp":1593134635000},"page":"707-712","source":"Crossref","is-referenced-by-count":4,"title":["Agranulozytose nach Metamizol-Einnahme \u2013 ein untersch\u00e4tztes Risiko?"],"prefix":"10.1055","volume":"99","author":[{"given":"Katharina","family":"Schinz","sequence":"additional","affiliation":[{"name":"Hals-Nasen-Ohren-Klinik, Kopf- und Halschirurgie, Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg, Erlangen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank","family":"Waldfahrer","sequence":"additional","affiliation":[{"name":"Hals-Nasen-Ohren-Klinik, Kopf- und Halschirurgie, Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg, Erlangen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wolfgang","family":"W\u00fcst","sequence":"additional","affiliation":[{"name":"Radiologisches Institut, Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg, Erlangen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heinrich","family":"Iro","sequence":"additional","affiliation":[{"name":"Hals-Nasen-Ohren-Klinik, Kopf- und Halschirurgie, Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg, Erlangen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2020,6,25]]},"reference":[{"key":"ref3","first-page":"A846","article-title":"\"UAW \u2013 Aus Fehlern lernen\u201c. Lebensbedrohliche hypotensive Reaktionen nach Metamizol","volume":"106","author":"Arzneimittelkommission der deutschen \u00c4rzteschaft","year":"2009","journal-title":"Dtsch Arztebl"},{"key":"ref4","first-page":"A1758","article-title":"Agranulozytose nach Metamizol \u2013 sehr selten, aber h\u00e4ufiger als gedacht","volume":"108","author":"Arzneimittelkommission der deutschen \u00c4rzteschaft","year":"2011","journal-title":"Dtsch Arztebl"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1007\/s00228-015-1895-y","article-title":"Metamizole (dipyrone)-associated agranulocytosis. 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