{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T03:14:08Z","timestamp":1767064448947},"reference-count":15,"publisher":"Georg Thieme Verlag KG","issue":"02","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Laryngorhinootologie"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title><jats:p>\n          Einleitung\u2002Zur Abgrenzung einer EBV-Prim\u00e4rinfektion von einer bakteriellen Tonsillitis wird eine EBV-Serologie empfohlen. Schneller verf\u00fcgbar ist, neben nur wenig zuverl\u00e4ssigen EBV-Schnelltests, ein instrumentelles Differenzialblutbild. Es wurde ausgewertet, ob sich hierbei bei bis zu 70\u200a% mononukle\u00e4r ver\u00e4nderten Lymphozyten signifikante Unterschiede zeigen und welche weiteren schnell verf\u00fcgbaren klinischen Parameter eine Unterscheidung erleichtern.<\/jats:p><jats:p>\n          Material und Methoden\u2002Es erfolgte eine retrospektive Auswertung der absoluten und relativen Lympho- und Monozytenzahlen, CRP und Leberwerte von allen station\u00e4ren Patienten (n\u200a=\u200a140) mit V.\u200aa. EBV-Prim\u00e4rinfektion im Zeitraum von 01\/2008\u201301\/2019 (mittleres Alter 21,4\u200a\u00b1\u200a6,6 Jahre, \u2640 51\u200a%, \u2642\u00a049\u200a%). Es erfolgte der Vergleich zwischen serologisch best\u00e4tigter (VCA-IgM+, VCA-IgG+, EBNA-IgG) oder ausgeschlossener EBV-Prim\u00e4rinfektion.<\/jats:p><jats:p>\n          Ergebnisse\u2002Bei best\u00e4tigter EBV-Prim\u00e4rinfektion und vorliegendem Differenzialblutbild (n\u200a=\u200a42) lag mit absoluten Lymphozyten von 5,5\u200a\u00b1\u200a2,6 Giga\/l im Mittel eine Lymphozytose vor, bei akuter bakterieller Tonsillitis (n\u200a=\u200a36) mit 1,6\u200a\u00b1 1,3\u00a0Giga\/l signifikant geringere Werte (p\u200a&lt;\u200a0,05). Entsprechendes ergab sich f\u00fcr die relativen Lymphozyten (47,4\u200a\u00b1 17,9\u200a% vs. 12,8\u200a\u00b1\u200a9,1\u200a%; p\u200a&lt;\u200a0,05). Es ergaben sich weder f\u00fcr die absoluten (1,2\u200a\u00b1\u200a0,8 vs. 1,2\u200a\u00b1\u200a0,6 Giga\/l; p\u200a=\u200a0,617) noch f\u00fcr die relativen (8,8\u200a\u00b1\u200a3,6 vs. 9,8\u200a\u00b1\u200a5,2\u200a%; p\u200a=\u200a0,746) Monozytenzahlen signifikante Unterschiede. Bei EBV-Prim\u00e4rinfektion fanden sich signifikant geringere CRP-Werte und signifikant h\u00f6here Leberwerte und eine Hepato-\/Splenomegalie.<\/jats:p><jats:p>\n          Schlussfolgerung\u2002Erh\u00f6hte Lymphozytenzahlen und ein erh\u00f6htes Verh\u00e4ltnis von Lympho- zu Leukozytenzahlen k\u00f6nnen einen ersten Hinweis auf eine EBV-Infektion geben. Morphologisch ver\u00e4nderte Lymphozyten werden offenbar mit modernen Ger\u00e4ten zunehmend korrekt gez\u00e4hlt. Zus\u00e4tzlich sind ein nur moderat erh\u00f6hter CRP-Wert und eine Hepatosplenomegalie charakteristisch f\u00fcr eine prim\u00e4re EBV-Infektion. Die Ergebnisse k\u00f6nnten genutzt werden, um die Entscheidung zur weiteren Diagnostik gezielter zu treffen, bevor eine EBV-Serologie vorliegt.<\/jats:p>","DOI":"10.1055\/a-1190-4712","type":"journal-article","created":{"date-parts":[[2020,6,23]],"date-time":"2020-06-23T05:28:24Z","timestamp":1592890104000},"page":"120-127","source":"Crossref","is-referenced-by-count":1,"title":["Stellenwert des maschinellen Blutbildes bei der Diagnose der\u00a0infekti\u00f6sen Mononukleose durch EBV"],"prefix":"10.1055","volume":"100","author":[{"given":"Franziska","family":"Stupp","sequence":"additional","affiliation":[{"name":"Hals-Nasen-Ohrenheilkunde, Kopf- und Halschirurgie, Universit\u00e4tsklinikum Ulm, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas Karl","family":"Hoffmann","sequence":"additional","affiliation":[{"name":"HNO, Univ.-Klinik Ulm, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna-Sophia","family":"Grossi","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Hals-Nasen-Ohrenheilkunde, Universit\u00e4tsklinikum Ulm, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabian","family":"Sommer","sequence":"additional","affiliation":[{"name":"HNO-Klinik, Universit\u00e4t Ulm, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hannah Lara","family":"Sieron","sequence":"additional","affiliation":[{"name":"Hals-Nasen-Ohrenheilkunde, Kopf- und Halschirurgie, Universit\u00e4tsklinikum Ulm, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00f6rg","family":"Lindemann","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr HNO-Heilkunde, Kopf- und Halschirurgie, Universit\u00e4tsklinik Ulm, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2020,6,22]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1055\/s-2007-1025428","article-title":"Hundert Jahre Pfeiffersches Dr\u00fcsenfieber","volume":"203","author":"F Graser","year":"1991","journal-title":"Klin P\u00e4diatr"},{"key":"ref2","first-page":"410","volume":"31","author":"T Sprunt","year":"1920","journal-title":"Bull John Hop Hosp"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1001\/archinte.1923.00110190085006","volume":"32","author":"H Downev","year":"1923","journal-title":"Arch Int Med"},{"key":"ref4","first-page":"1495","volume":"48","author":"W Schult","year":"1922","journal-title":"DIseh med Wschr"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1128\/CDLI.7.3.451-456.2000","article-title":"Evaluation of 12 commercial tests for detection of Epstein-Barr virus-specific and heterophile antibodies","volume":"7","author":"A L Bruu","year":"2000","journal-title":"Clin Diagn Lab Immunol"},{"key":"ref13","volume-title":"Labormedizin Indikation, Methodik und Laborwerte, Pathophysiologie und Klinik","author":"H D Bruhn","year":"2011","edition":"3. 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