{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,3,29]],"date-time":"2022-03-29T05:34:16Z","timestamp":1648532056760},"reference-count":17,"publisher":"Georg Thieme Verlag KG","issue":"03","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Laryngorhinootologie"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title><jats:p>Gem\u00e4\u00df der S2k-Leitlinie \u201eGastro\u00f6sophageale Refluxkrankheit (engl. GERD)\u201c von 05\/2014 wird bei der extra\u00f6sophagealen GERD-Manifestation (z.\u200aB. mit Ausbildung eines Kontaktgranuloms, KG) eine empirische Protonenpumpeninhibitor (PPI)-Therapie in doppelter Standarddosis (z.\u200aB. Pantoprazol 40\u200amg 2-mal\/Tag) \u00fcber 8 Wochen angeraten. Valide Studiendaten existieren hierzu jedoch nicht.<\/jats:p><jats:p>Im Rahmen einer prospektiven Studie von 05\/2015\u201312\/2019 erhielten 39 Patienten mit endoskopisch nachgewiesenem KG konsekutiv randomisiert PPI in einfacher (1-mal PPI, n\u200a=\u200a22) bzw. doppelter Standarddosis (2-mal PPI, n\u200a=\u200a17) f\u00fcr 8 Wochen. Es wurden bei Erstvorstellung und bei Kontrolle nach 4\u00a0Monaten ein m\u00f6glicher gastrolaryngealer Reflux sowie Halssensationen, R\u00e4usperneigung oder Heiserkeit erfasst und eine Videolaryngostroboskopie durchgef\u00fchrt, um die Befundentwicklung des Granuloms zu beurteilen (Progredienz, gleichbleibend, Remission &lt;\u200a50\u200a%, &gt;\u200a50\u200a% oder komplett). Die beiden Gruppen wurden miteinander verglichen.<\/jats:p><jats:p>Das Granulom war in 40\u200a% der F\u00e4lle nach Therapie mit 1-mal PPI und in 77\u200a% der F\u00e4lle mit 2-mal PPI verschwunden bzw. regredient (p\u200a&lt;\u200a0,05). Bei Kontrolle waren 23\u200a% der Patienten mit 1-mal PPI v\u00f6llig symptomlos und 77\u200a% der Patienten mit 2-mal PPI. Halssensationen wurden bei Erstvorstellung mit 64\u200a% als h\u00e4ufigstes Symptom angegeben. Bei der Kontrolle nach PPI-Therapie in einfacher bzw. doppelter Standarddosis waren Halssensationen nur noch in 33\u200a% bzw. 15\u200a% der F\u00e4lle bei Granulomremission nachweisbar. Bei Persistenz des Granuloms waren sie jedoch kaum beeinflussbar.<\/jats:p><jats:p>Die Therapie eines KG mit PPI in doppelter Standarddosis ist effektiver als in einfacher Standarddosis. Diese Ergebnisse m\u00fcssen an einem gr\u00f6\u00dferen Kollektiv best\u00e4tigt werden.<\/jats:p>","DOI":"10.1055\/a-1190-4907","type":"journal-article","created":{"date-parts":[[2020,6,17]],"date-time":"2020-06-17T23:58:19Z","timestamp":1592438299000},"page":"202-206","source":"Crossref","is-referenced-by-count":0,"title":["Therapieerfolg von Protonenpumpeninhibitoren bei der Therapie von Kontaktgranulomen"],"prefix":"10.1055","volume":"100","author":[{"given":"Adrienne","family":"Heyduck","sequence":"additional","affiliation":[{"name":"Sektion Phoniatrie und P\u00e4daudiologie der Klinik f\u00fcr Hals-Nasen-Ohrenheilkunde, Kopf- und Halschirurgie, Univ.-Klinik Ulm, Ulm, Germany"},{"name":"Klinik f\u00fcr Hals-Nasen-Ohrenheilkunde, Universit\u00e4tsmedizin G\u00f6ttingen, Phoniatrie und P\u00e4daudiologie, G\u00f6ttingen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anja","family":"Pickhard","sequence":"additional","affiliation":[{"name":"Hals-Nasen-Ohrenklinik, Technische Universit\u00e4t M\u00fcnchen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arno","family":"Olthoff","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Hals-Nasen-Ohrenheilkunde, Universit\u00e4tsmedizin G\u00f6ttingen, Phoniatrie und P\u00e4daudiologie, G\u00f6ttingen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Hoffmann","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Hals-Nasen-Ohrenheilkunde, Kopf- und Halschirurgie, Univ.-Klinik Ulm, Ulm, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rudolf","family":"Reiter","sequence":"additional","affiliation":[{"name":"Sektion Phoniatrie und P\u00e4daudiologie der Klinik f\u00fcr Hals-Nasen-Ohrenheilkunde, Kopf- und Halschirurgie, 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