{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,12]],"date-time":"2024-08-12T09:40:13Z","timestamp":1723455613776},"reference-count":18,"publisher":"Georg Thieme Verlag KG","issue":"04","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tierarztl Prax Ausg K Kleintiere Heimtiere"],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title><jats:p>Gegenstand und Ziel Ein kommerziell erh\u00e4ltliches Arzneimittel mit hom\u00f6opathischen Inhaltsstoffen zeigte erste Erfolge bei Hunden mit atopischer Dermatitis. Ziel dieser Fallserie war, die Wirkung des Arzneimittels bei einer gr\u00f6\u00dferen Anzahl von Hunden mit dieser Erkrankung zu bewerten.<\/jats:p><jats:p>Material und Methoden Zehn Hunde mit atopischer Dermatitis erhielten das hom\u00f6opathische Kombinationsarzneimittel t\u00e4glich oral \u00fcber 3 Wochen nach Herstellerangabe. Die Diagnose der atopischen Dermatitis wurde zuvor anhand von Anamnese, klinischer Untersuchung und Ausschluss von Differenzialdiagnosen gestellt. Ein Ausschluss von bakteriellen und mykotischen Hautinfektionen erfolgte durch die klinische Untersuchung und die zytologische Evaluierung von Abklatschpr\u00e4paraten der Haut. Patienten mit zus\u00e4tzlicher Futtermittel-allergie erhielten ab mindestens 2 Monate vor Beginn sowie w\u00e4hrend der gesamten Dauer der Studie eine Eliminationsdi\u00e4t. Bei Hunden mit vermuteter oder best\u00e4tigter Flohspeichelallergie fand mindestens 1 Monat vor sowie w\u00e4hrend der Studie eine Flohprophylaxe statt. Die klinische Symptomatik wurde anhand eines validierten Juckreizscores (Pruritus Visual Analogue Scale, PVAS) und eines validierten L\u00e4sionsscores (Canine Atopic Dermatitis Lesion Index, CADLI) vor und nach der Therapie evaluiert. Zus\u00e4tzlich beurteilten die Tierbesitzer die Fellqualit\u00e4t. Potenzielle Nebenwirkungen wurden bei dem Kontrolltermin vermerkt.<\/jats:p><jats:p>Ergebnisse Im Verlauf der Behandlung ergaben sich keine signifikanten Ver\u00e4nderungen der L\u00e4sionen (Wilcoxon-Test, p = 1,0), des Pruritus (gepaarter t-Test, p = 0,34) und der Fellqualit\u00e4t (gepaarter t-Test, p = 0,34). Nur ein Patient zeigte eine geringgradige Verbesserung des Juckreizes und der Fellqualit\u00e4t. Nebenwirkungen traten nicht auf.<\/jats:p><jats:p>Schlussfolgerung und klinische Relevanz In dieser Fallserie zeigte das getestete hom\u00f6opathische Arzneimittel keinen positiven Einfluss auf die klinischen Anzeichen von kaniner atopischer Dermatitis.<\/jats:p>","DOI":"10.1055\/a-1193-3733","type":"journal-article","created":{"date-parts":[[2020,8,21]],"date-time":"2020-08-21T22:51:56Z","timestamp":1598050316000},"page":"245-248","source":"Crossref","is-referenced-by-count":0,"title":["Wirkung eines hom\u00f6opathischen Arzneimittels auf die klinische Symptomatik von Hunden mit atopischer Dermatitis"],"prefix":"10.1055","volume":"48","author":[{"given":"Teresa M. S. A.","family":"Boehm","sequence":"additional","affiliation":[{"name":"Medizinische Kleintierklinik, Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christoph J.","family":"Klinger","sequence":"additional","affiliation":[{"name":"Tierklinik Stuttgart Plieningen"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Udraite","sequence":"additional","affiliation":[{"name":"Medizinische Kleintierklinik, Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ralf S.","family":"Mueller","sequence":"additional","affiliation":[{"name":"Medizinische Kleintierklinik, Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2020,8,21]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1336","DOI":"10.2460\/javma.1999.214.09.1336","article-title":"Health status and population characteristics of dogs and cats examined at private veterinary practices in the United States","volume":"214","author":"E M Lund","year":"1999","journal-title":"J Am Vet Med Assoc"},{"key":"ref2","first-page":"830","article-title":"A survey of canine and feline skin disorders seen in a university practice: Small Animal Clinic, University of Montreal, Saint-Hyacinthe, Quebec (1987\u20131988)","volume":"31","author":"D W Scott","year":"1990","journal-title":"Can Vet J"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/S0165-2427(01)00343-9","article-title":"The ACVD task force on canine atopic dermatitis: forewords and lexicon","volume":"81","author":"T Olivry","year":"2001","journal-title":"Vet Immunol Immunopathol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1136\/vr.101767","article-title":"Veterinary homeopathy: systematic review of medical conditions studied by randomised placebo-controlled trials","volume":"175","author":"R T Mathie","year":"2014","journal-title":"Vet Rec"},{"key":"ref5","first-page":"170","article-title":"Comparison of veterinary drugs and veterinary homeopathy: part 1","volume":"181","author":"P Lees","year":"2017","journal-title":"Vet Rec"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1136\/vr.104279","article-title":"Comparison of veterinary drugs and veterinary homeopathy: part 2","volume":"181","author":"P Lees","year":"2017","journal-title":"Vet Rec"},{"key":"ref7","first-page":"210","article-title":"Treatment of canine atopic dermatitis: 2015 updated guidelines from the International Committee on Allergic Diseases of Animals (ICADA)","volume":"11","author":"T Olivry","year":"2015","journal-title":"BMC Vet Res"},{"key":"ref9","first-page":"515","article-title":"Development and validation of the Canine Atopic Dermatitis Lesion Index, a scale for the rapid scoring of lesion severity in canine atopic dermatitis","volume":"23","author":"J D Plant","year":"2012","journal-title":"Vet Dermatol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1111\/j.1365-3164.2008.00728.x","article-title":"Further validation of a pruritus severity scale for use in dogs","volume":"20","author":"J Rybn\u00edcek","year":"2009","journal-title":"Vet Dermatol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1111\/j.1365-3164.2007.00616.x","article-title":"Development of an owner-assessed scale to measure the severity of pruritus in dogs","volume":"18","author":"P B Hill","year":"2007","journal-title":"Vet Dermatol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1136\/vr.164.12.364","article-title":"Pilot study of the effect of individualised homeopathy on the pruritus associated with atopic dermatitis in dogs","volume":"164","author":"P B Hill","year":"2009","journal-title":"Vet Rec"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1038\/nature03383","article-title":"Ultrafast memory loss and energy redistribution in the hydrogen bond network of liquid H2O","volume":"434","author":"M L Cowan","year":"2005","journal-title":"Nature"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1089\/acm.2006.12.437","article-title":"Thermoluminescence in ultra-high dilution research","volume":"12","author":"Rv Wijk","year":"2006","journal-title":"J Altern Complement Med"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1080\/14328917.2005.11784911","article-title":"The structure of liquid water; novel insights from materials research; potential relevance to homeopathy","volume":"9","author":"R Roy","year":"2005","journal-title":"Mater Res Innov"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/S0378-4371(03)00047-5","article-title":"Thermoluminescence of ultra-high dilutions of lithium chloride and sodium chloride","volume":"323","author":"L Rey","year":"2003","journal-title":"Physica A"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1054\/homp.1999.0457","article-title":"On the investigation of homeopathic potencies using low resolution NMR T2 relaxation times: an experimental and critical survey of the work of Roland Conte et al","volume":"90","author":"L R Milgrom","year":"2001","journal-title":"Br Homeopath J"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1007\/s10973-005-7266-7","article-title":"\u2018Extremely diluted solutions\u2019 as multi-variable systems: A study of calorimetric and conductometric behaviour as a function of the parameter time","volume":"84","author":"V Elia","year":"2006","journal-title":"J Therm Anal Calorim"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1054\/homp.1999.0458","article-title":"Nuclear magnetic resonance (NMR) studies of homeopathic solutions","volume":"90","author":"S Aabel","year":"2001","journal-title":"Br Homeopath J"}],"container-title":["Tier\u00e4rztliche Praxis Ausgabe K: Kleintiere \/ Heimtiere"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-1193-3733.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,12]],"date-time":"2024-08-12T09:17:43Z","timestamp":1723454263000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-1193-3733"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8]]},"references-count":18,"journal-issue":{"issue":"04","published-online":{"date-parts":[[2020,8,21]]},"published-print":{"date-parts":[[2020,8]]}},"URL":"https:\/\/doi.org\/10.1055\/a-1193-3733","relation":{},"ISSN":["1434-1239","2567-5842"],"issn-type":[{"type":"print","value":"1434-1239"},{"type":"electronic","value":"2567-5842"}],"subject":[],"published":{"date-parts":[[2020,8]]}}}