{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,8]],"date-time":"2024-08-08T16:10:14Z","timestamp":1723133414542},"reference-count":60,"publisher":"Georg Thieme Verlag KG","issue":"02","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Laryngorhinootologie"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title><jats:p>Hintergrund\u2002Die \u00d6sophagoskopie als Teil der Panendoskopie ist ein wichtiger Bestandteil der Diagnostik und Nachsorge von Patienten mit Kopf-Hals-Plattenepithelkarzinomen (HNSCC). Zweitkarzinome haben gravierenden Einfluss auf die Therapie der Prim\u00e4rerkrankung. Diese Arbeit soll pr\u00fcfen, ob die routinem\u00e4\u00dfige \u00d6sophagoskopie gerechtfertigt ist oder ob pr\u00e4diktive Faktoren eine Selektion von Patienten mit erh\u00f6htem Risikoprofil erlauben.<\/jats:p><jats:p>Material und Methoden\u2002In einem systematischen Review wurden die Inzidenz von Zweitkarzinomen des \u00d6sophagus und die Komplikationsrate der \u00d6sophagoskopie erfasst. Eine retrospektive Auswertung erfolgte am eigenen Patientenkollektiv. Zur Evaluation der g\u00e4ngigen Praxis an deutschen HNO-Kliniken wurde eine Umfrage durchgef\u00fchrt.<\/jats:p><jats:p>Ergebnisse\u20021053 \u00d6sophagoskopien bei 800 Patienten mit HNSCC wurden ausgewertet. Es traten 7 (0,9\u200a%) synchrone Zweittumoren auf. In 253 Kontroll-\u00d6sophagoskopien wurden 5 (2\u200a%) metachrone Zweittumoren detektiert. In einem Fall (0,1\u200a%) kam es zu einer iatrogenen Perforation. Ein Zusammenhang zwischen Risikofaktoren (Noxen, Lokalisation Prim\u00e4rtumor etc.) und der Inzidenz von Zweitkarzinomen wurde nicht nachgewiesen. Das Literaturreview ergab eine mittlere gewichtete Inzidenz der Zweitkarzinome f\u00fcr Europa\/USA von 1,8\u200a% und 4,1\u200a% f\u00fcr Asien sowie eine Rate der iatrogenen \u00d6sophagusperforation von 0\u20130,2\u200a%. Die Umfrage zeigte eine routinem\u00e4\u00dfige Durchf\u00fchrung der \u00d6sophagoskopie im Staging (100\u200a%), in der Nachsorge in 65,3\u200a%.<\/jats:p><jats:p>Schlussfolgerungen\u2002Die \u00d6sophagoskopie ist ein sicheres Verfahren zum Ausschluss eines Zweitkarzinoms des \u00d6sophagus. Um eine Patientenselektion nach entsprechendem Risikoprofil \u2013 insbesondere in der Tumornachsorge \u2013 zu erm\u00f6glichen, sind prospektive multizentrische Studien erforderlich.<\/jats:p>","DOI":"10.1055\/a-1197-6978","type":"journal-article","created":{"date-parts":[[2020,6,26]],"date-time":"2020-06-26T23:57:14Z","timestamp":1593215834000},"page":"111-119","source":"Crossref","is-referenced-by-count":0,"title":["Evaluation der \u00d6sophagoskopie im Staging und Restaging von Kopf-Hals-Plattenepithelkarzinomen"],"prefix":"10.1055","volume":"100","author":[{"given":"Lena","family":"Weber","sequence":"additional","affiliation":[{"name":"Klinik und Poliklinik f\u00fcr Hals-Nasen-Ohrenheilkunde, Universit\u00e4tsklinikum Regensburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oliver","family":"Blachutzik","sequence":"additional","affiliation":[{"name":"Hals-Nasen-Ohrenklinik und Poliklinik, Johannes-Gutenberg-Universit\u00e4t Mainz, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Veronika","family":"Vielsmeier","sequence":"additional","affiliation":[{"name":"Klinik und Poliklinik f\u00fcr Hals-Nasen-Ohrenheilkunde, Universit\u00e4tsklinikum Regensburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kornelia","family":"Andorfer","sequence":"additional","affiliation":[{"name":"Klinik und Poliklinik f\u00fcr Hals-Nasen-Ohrenheilkunde, Universit\u00e4tsklinikum Regensburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christoph","family":"Matthias","sequence":"additional","affiliation":[{"name":"Hals-Nasen-Ohrenklinik und Poliklinik, Johannes-Gutenberg-Universit\u00e4t Mainz, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julian","family":"K\u00fcnzel","sequence":"additional","affiliation":[{"name":"Klinik und Poliklinik f\u00fcr Hals-Nasen-Ohrenheilkunde, Universit\u00e4tsklinikum Regensburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2020,6,26]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1933","DOI":"10.1002\/1097-0142(19941001)74:7<1933::AID-CNCR2820740718>3.0.CO;2-X","article-title":"Synchronous and metachronous head and neck carcinomas","volume":"74","author":"L H Schwartz","year":"1994","journal-title":"Cancer"},{"key":"ref2","first-page":"2795","article-title":"Multiple Primary Malignant Tumors \u2013 A Clinical Analysis of 15321 Patients with Malignancies at a Single Center in China","volume":"9","author":"C Zhai","year":"2018","journal-title":"J\u00a0Cancer"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1038\/sj.bjc.6600018","article-title":"Screening for oesophageal neoplasia in patients with head and neck cancer","volume":"86","author":"H Scherubl","year":"2002","journal-title":"British journal of cancer"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1001\/archotol.1985.00800110067004","article-title":"The role of endoscopy in evaluating patients with head and neck cancer. 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