{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,3,29]],"date-time":"2022-03-29T03:27:35Z","timestamp":1648524455519},"reference-count":11,"publisher":"Georg Thieme Verlag KG","issue":"03","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dtsch Med Wochenschr"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:title>Was ist neu?<\/jats:title><jats:p>\n          Hyponatri\u00e4mie und klinische Symptome\u2002Neuere Untersuchungen veranschaulichen das breite Spektrum der klinischen Hyponatri\u00e4mie-assoziierten Symptome und weisen auf erhebliche kognitive Einschr\u00e4nkungen bei bereits milder Hyponatri\u00e4mie hin.<\/jats:p><jats:p>\n          Hyponatri\u00e4mie und ihre Ursachen\u2002Eine genomweite Assoziationsstudie (GWAS) identifizierte bei Patienten mit Thiazid-induzierter Hyponatri\u00e4mie ADH-unabh\u00e4ngige \u201eloss-of-function\u201c-Mutationen, die zu einer verminderten Aktivit\u00e4t des Prostaglandin-Transporters im Sammelrohr der Nieren f\u00fchren. Diese genetische Pr\u00e4disposition verst\u00e4rkt die Aquaporin-2-Expression und beg\u00fcnstigt die Wasserr\u00fcckresorption. Auch andere Medikamente wie Fluconazol k\u00f6nnen ADH-unabh\u00e4ngige Wirkungen auf AQP2 und die Wasserr\u00fcckresorption entfalten.<\/jats:p><jats:p>\n          Akute vs. chronische Hyponatri\u00e4mie und Korrekturgeschwindigkeit\u2002Etwa 25\u201350\u200a% der Hyponatri\u00e4mie-Patienten erfahren eine \u00dcberkorrektur mit zu schnellem Anstieg des Serum-Na+. Die Bestimmung von Urin-Osmolarit\u00e4t und freier Wasser-Clearance kann helfen \u00dcberkorrekturen zu vermeiden.<\/jats:p><jats:p>\n          Aktuelle Studien\u2002Neben etablierten SIADH-Therapien wie Fl\u00fcssigkeitsrestriktion, hyperosmolaren Salzinfusionen und Harnstoffgabe wird gegenw\u00e4rtig der Wert von SGLT2-Inhibitoren zur Behandlung von Patienten mit Hyponatri\u00e4mie untersucht.<\/jats:p>","DOI":"10.1055\/a-1198-3814","type":"journal-article","created":{"date-parts":[[2021,1,29]],"date-time":"2021-01-29T23:31:34Z","timestamp":1611963094000},"page":"176-180","source":"Crossref","is-referenced-by-count":0,"title":["Hyponatri\u00e4mie \u2013 Ursachen, Diagnostik und Therapie"],"prefix":"10.1055","volume":"146","author":[{"given":"Ralph","family":"Kettritz","sequence":"additional","affiliation":[{"name":"Nephrologie und Internistische Intensivmedizin, Charit\u00e9-Universit\u00e4tsmedizin Berlin und Experimental and Clinical Research Center (ECRC) Berlin-Buch"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2021,1,29]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1111\/jgs.13325","article-title":"Symptoms and characteristics of individuals with profound hyponatremia: a prospective multicenter observational study","volume":"63","author":"N Nigro","year":"2015","journal-title":"J Am Geriatr Soc"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"366","DOI":"10.2215\/CJN.07400717","article-title":"Serum Sodium and Cognition in Older Community-Dwelling Men","volume":"13","author":"K L Nowak","year":"2018","journal-title":"Clin J Am Soc Nephrol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1177\/0004563220922255","article-title":"Electrolyte imbalances in patients with severe coronavirus disease 2019 (COVID-19)","volume":"57","author":"G Lippi","year":"2020","journal-title":"Ann Clin Biochem"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"3367","DOI":"10.1172\/JCI89812","article-title":"Phenotypic and pharmacogenetic evaluation of patients with thiazide-induced hyponatremia","volume":"127","author":"J S Ware","year":"2017","journal-title":"J Clin Invest"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1681\/ASN.2018060668","article-title":"Fluconazole Increases Osmotic Water Transport in Renal Collecting Duct through Effects on Aquaporin-2 Trafficking","volume":"30","author":"T Vukicevic","year":"2019","journal-title":"J Am Soc Nephrol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"984","DOI":"10.2215\/CJN.13061117","article-title":"Risk Factors and Outcomes of Rapid Correction of Severe Hyponatremia","volume":"13","author":"J C George","year":"2018","journal-title":"Clin J Am Soc Nephrol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1053\/j.ajkd.2017.12.002","article-title":"Rapidity of Correction of Hyponatremia Due to Syndrome of Inappropriate Secretion of Antidiuretic Hormone Following Tolvaptan","volume":"71","author":"J H Morris","year":"2018","journal-title":"Am J Kidney Dis"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1053\/j.ajkd.2009.12.024","article-title":"A patient with severe hyponatremia and hypokalemia: osmotic demyelination following potassium repletion","volume":"55","author":"T Berl","year":"2010","journal-title":"Am J Kidney Dis"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.2215\/CJN.04020318","article-title":"Urea for the Treatment of Hyponatremia","volume":"13","author":"H Rondon-Berrios","year":"2018","journal-title":"Clin J Am Soc Nephrol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1056\/NEJMc1508385","article-title":"Vasopressin Antagonists","volume":"373","author":"F Vandergheynst","year":"2015","journal-title":"N Engl J Med"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1681\/ASN.2019090944","article-title":"A Randomized Trial of Empagliflozin to Increase Plasma Sodium Levels in Patients with the Syndrome of Inappropriate Antidiuresis","volume":"31","author":"J Refardt","year":"2020","journal-title":"J Am Soc Nephrol"}],"container-title":["DMW - Deutsche Medizinische Wochenschrift"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-1198-3814.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,1,29]],"date-time":"2021-01-29T23:32:40Z","timestamp":1611963160000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-1198-3814"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1,29]]},"references-count":11,"journal-issue":{"issue":"03","published-online":{"date-parts":[[2021,1,29]]},"published-print":{"date-parts":[[2021,2]]}},"URL":"https:\/\/doi.org\/10.1055\/a-1198-3814","relation":{},"ISSN":["0012-0472","1439-4413"],"issn-type":[{"value":"0012-0472","type":"print"},{"value":"1439-4413","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1,29]]}}}