{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T10:28:08Z","timestamp":1769596088317,"version":"3.49.0"},"reference-count":21,"publisher":"Georg Thieme Verlag KG","issue":"02","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Klin Padiatr"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Lymphedema is a localized form of tissue swelling, characterized by a progressive\n                    accumulation of a tissue fluid in the interstitial compartment as a result of\n                    the lymphatic system dysfunction. It is a rare disease in the pediatric\n                    population and in the majority of cases it is a consequence of an abnormal\n                    formation of the lymphatic system, which is called primary lymphedema. Although\n                    its epidemiology is not precise, it is assumed that 1:100 000 children suffer\n                    from primary lymphedema. The diagnosis can be made by a proper clinical\n                    examination after ruling out secondary causes of lymphedema, particularly in\n                    cases with a more asymmetric swelling of the extremities. In this very article\n                    we present a case report of an 8-months-old infant with primary lymphedema, who\n                    had presented swelling of the extremities from birth and yet no pathology was\n                    suspected before. The purpose of this article is to draw attention to the fact\n                    that a baby with excessive subcutaneous tissue is not always a healthy, chubby\n                    infant with considerable amount of fat tissue.<\/jats:p>","DOI":"10.1055\/a-1200-1721","type":"journal-article","created":{"date-parts":[[2020,7,13]],"date-time":"2020-07-13T22:48:39Z","timestamp":1594680519000},"page":"47-52","source":"Crossref","is-referenced-by-count":3,"title":["Chubby Infant \u2013 Should One Worry? An Infant with Primary\n                    lymphedema \u2013 Mini Review and Case Report"],"prefix":"10.1055","volume":"233","author":[{"given":"Joanna Magdalena","family":"Kaczmarek","sequence":"additional","affiliation":[{"name":"SRC Pediatrics, Allergology and Gastroenterology, Bydgoszcz, Nicolaus\n                    Copernicus University in Toru\u0144 Ludwik Rydygier Collegium Medicum in\n                    Bydgoszcz, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karolina Anna","family":"Graczykowska","sequence":"additional","affiliation":[{"name":"SRC Pediatrics, Allergology and Gastroenterology, Bydgoszcz, Nicolaus\n                    Copernicus University in Toru\u0144 Ludwik Rydygier Collegium Medicum in\n                    Bydgoszcz, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iwona","family":"Szymku\u0107-Bukowska","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation, Bydgoszcz, Nicolaus Copernicus University\n                    in Toru\u0144 Ludwik Rydygier Collegium Medicum in Bydgoszcz,\n                    Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ewa","family":"\u0141o\u015b-Rycharska","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Allergology and Gastroenterology, Bydgoszcz,\n                    Nicolaus Copernicus University in Toru\u0144 Ludwik Rydygier Collegium\n                    Medicum in Bydgoszcz, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aneta","family":"Krogulska","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Allergology and Gastroenterology, Bydgoszcz,\n                    Nicolaus Copernicus University in Toru\u0144 Ludwik Rydygier Collegium\n                    Medicum in Bydgoszcz, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2020,7,13]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"179","DOI":"10.5606\/tftrd.2018.3539","article-title":"Lymphedema diagnosis, treatment, and follow-up from the viewpoint of physical\n                    medicine and rehabilitation specialists","volume":"64","author":"P Borman","year":"2018","journal-title":"Turk J Phys Med Rehabil"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1172\/JCI71614","article-title":"Genetics of lymphatic anomalies","volume":"124","author":"P Brouillard","year":"2014","journal-title":"J Clin Invest"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1258\/phleb.2008.008010","article-title":"Diagnosis and therapy in children with lymphoedema","volume":"23","author":"R J Damstra","year":"2008","journal-title":"Phlebology"},{"key":"ref4","first-page":"e1223","article-title":"Resolution of Primary Lymphedema: A Case Report","volume":"5","author":"J A Goss","year":"2017","journal-title":"Plast Reconstr Surg"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1089\/lrb.2017.0085","article-title":"Primary Lymphedema of the Upper Extremities: Clinical and Lymphoscintigraphic\n                    Features in 23 Patients","volume":"17","author":"J A Goss","year":"2019","journal-title":"Lymphat Res Biol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"451","DOI":"10.3889\/oamjms.2017.082","article-title":"Hereditary lymphedema of the leg \u2013 a case report","volume":"5","author":"B Heinig","year":"2017","journal-title":"Open Access Maced J Med Sci"},{"key":"ref7","first-page":"23","article-title":"Obrz\u0119k limfatyczny \u2013 przegl\u0105d literatury","volume":"4","author":"P Macek","year":"2010","journal-title":"Onkologia i Radioterapia"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1097\/SAP.0000000000000022","article-title":"Management of Primary and Secondary Lymphedema, Analysis of 225 Referrals to a\n                    Center","volume":"75","author":"R A Maclellan","year":"2015","journal-title":"Ann Plast Surg"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1053\/j.sempedsurg.2014.07.004","article-title":"Lymphedema","volume":"23","author":"R A Maclellan","year":"2014","journal-title":"Seminars in Pediatric Surgery"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1159\/000354097","article-title":"Mutations in the VEGFR3 signalling pathway explain 36% of familial\n                    lymphedema","volume":"4","author":"A Mendola","year":"2013","journal-title":"Molecular syndromology"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"1682","DOI":"10.3889\/oamjms.2018.261","article-title":"Unilateral Primary Congenital Lymphedema of the Upper Limb in an 11-Month-Old\n                    Infant: A Clinical and Pharmacological Perspective","volume":"18","author":"G G Meshram","year":"2018","journal-title":"Open Access Maced J Med Sci"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1093\/qjmed\/hcg126","article-title":"Lymphoedema: An underestimated health problem","volume":"96","author":"C J Moffatt","year":"2003","journal-title":"QJM"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"1571","DOI":"10.1097\/PRS.0b013e31820a64f3","article-title":"Differential Diagnosis of Lower Extremity Enlargement in Pediatric Patients\n                    Referred with a Diagnosis of Lymphedema","volume":"127","author":"C C Schook","year":"2011","journal-title":"Plast Reconstr Surg"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"2419","DOI":"10.1097\/PRS.0b013e318213a218","article-title":"Primary Lymphedema: Clinical Features and Management in 138 Pediatric\n                    Patients","volume":"127","author":"C C Schook","year":"2011","journal-title":"Plast Reconstr Surg"},{"key":"ref15","first-page":"206","article-title":"Primary lymphedema in children and adolescents: A follow-up study and\n                    review","volume":"76","author":"D M Smeltzer","year":"1985","journal-title":"Pediatrics"},{"key":"ref16","first-page":"590","article-title":"Interna Szczeklika, podr\u0119cznik chor\u00f3b wewn\u0119trznych\n                    2018","author":"A Szuba","year":"2018","journal-title":"Medycyna Praktyczna; Krak\u00f3w"},{"key":"ref17","first-page":"170","article-title":"The diagnosis and treatment of the peripheral lymphoedema: 2016 Consensus\n                    Document of The International Society of Lymphology","volume":"49","year":"2016","journal-title":"Lymphology"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1001\/archsurg.138.2.152","article-title":"Differential Diagnosis, Investigation, and Current Treatment of Lower Limb\n                    Lymphedema","volume":"138","author":"A Tiwari","year":"2003","journal-title":"Arch Surg"},{"key":"ref19","first-page":"37","article-title":"Limphoedema: lymphoscintigraphy versus other diagnostic techniques \u2013 a\n                    clinician\u02bcs point of view","volume":"8","author":"H Tomczak","year":"2005","journal-title":"Nucl Med Rev Cent East Eur"},{"key":"ref20","first-page":"97","article-title":"Lymphedema: From diagnosis to treatment","volume":"38","author":"S Vignes","year":"2017","journal-title":"Rev Med Interne"},{"key":"ref21","first-page":"4","article-title":"Patologia obrz\u0119ku ch\u0142onnego","volume":"8","author":"M Wiktor","year":"2013","journal-title":"Chirurgia po Dyplomie"}],"container-title":["Klinische P\u00e4diatrie"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-1200-1721.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,3,9]],"date-time":"2021-03-09T00:04:03Z","timestamp":1615248243000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-1200-1721"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7,13]]},"references-count":21,"journal-issue":{"issue":"02","published-online":{"date-parts":[[2021,3,8]]},"published-print":{"date-parts":[[2021,3]]}},"URL":"https:\/\/doi.org\/10.1055\/a-1200-1721","relation":{},"ISSN":["0300-8630","1439-3824"],"issn-type":[{"value":"0300-8630","type":"print"},{"value":"1439-3824","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,7,13]]}}}