{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T08:33:37Z","timestamp":1740126817484,"version":"3.37.3"},"reference-count":22,"publisher":"Georg Thieme Verlag KG","issue":"01","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Klin Padiatr"],"published-print":{"date-parts":[[2021,1]]},"abstract":"Zusammenfassung<\/jats:title>\n Hintergrund In der Leitlinie zur Prophylaxe der fr\u00fchen Form\n (Early Onset Sepsis, EOS) der Neugeborenensepsis durch Streptokokken der Gruppe\n B (GBS) wird ein GBS Screening aller Schwangeren empfohlen. Dieses ist jedoch\n nicht Bestandteil der Mutterschaftsrichtlinien. Studienziel war die\n \u00dcberpr\u00fcfung des zeitlichen Verlaufs der Infektionsrate im\n Zusammenhang mit dem GBS Screening.<\/jats:p>\n Methodik Krankenversicherungsdaten der Jahre 2005 bis 2017 von\n 313\u2009385 BARMER versicherten Mutter-Kind Paaren wurden analysiert.\n \u00dcber die ICD-10 P36.0 wurde die j\u00e4hrliche H\u00e4ufigkeit von\n GBS Infektionen bei Neugeborenen ermittelt. Als Surrogat f\u00fcr das GBS\n Screening wurde die ICD-10 B95.1 verwendet, welche bekannte positive\n m\u00fctterliche GBS Besiedelung beschreibt. Durch logistische\n Regressionsmodelle wurden die zeitliche Ver\u00e4nderungen des\n Erkrankungsrisikos von EOS bei Neugeborenen untersucht.\n Pearson-Korrelationskoeffizient wurde zur Bewertung des Zusammenhangs zwischen\n der zeitlichen Ver\u00e4nderung der H\u00e4ufigkeit an EOS und dem\n Surrogatmarker f\u00fcr GBS Besiedelung verwendet.<\/jats:p>\n Ergebnisse Das Erkrankungsrisiko der EOS bei Neugeborenen hat\n j\u00e4hrlich um 9,3% abgenommen, gesamt \u00fcber die\n Beobachtungsjahre um 72,0%, w\u00e4hrend f\u00fcr die\n Sp\u00e4tform LOS (Late Onset Sepsis) keine statistisch signifikante\n Ver\u00e4nderung beobachtet wurde. Diese Abnahme konnte nicht durch zeitliche\n Ver\u00e4nderungen bei Kaiserschnitten, Risikofaktoren oder\n Fr\u00fchgeburten erkl\u00e4rt werden. Eine gleichzeitige Erh\u00f6hung\n des Anteils der M\u00fctter mit bekanntem positivem GBS Status um den Faktor\n 3,5 korrelierte invers (r=\u2212\u20090,75; p=0,002) mit\n der Inzidenz von EOS.<\/jats:p>\n Schlussfolgerung Die starke Abnahme der EOS in Deutschland bei\n unver\u00e4nderter Inzidenz von LOS k\u00f6nnte durch eine zunehmende\n Umsetzung des Schwangerenscreenings erkl\u00e4rt werden.<\/jats:p>","DOI":"10.1055\/a-1202-1758","type":"journal-article","created":{"date-parts":[[2020,7,22]],"date-time":"2020-07-22T23:15:23Z","timestamp":1595459723000},"page":"17-23","source":"Crossref","is-referenced-by-count":1,"title":["R\u00fcckgang von Infektionen durch Streptokokken der Gruppe B bei\n Neugeborenen: Analyse von Krankenversicherungsdaten 2005 bis\n 2017"],"prefix":"10.1055","volume":"233","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6255-7758","authenticated-orcid":false,"given":"Anna-Lisa","family":"Sorg","sequence":"first","affiliation":[{"name":"Institute for Social Pediatrics and Adolescent Medicine, Pediatric\n Epidemiology, Ludwig Maximilians University Munich, Munich"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Viola","family":"Obermeier","sequence":"first","affiliation":[{"name":"Institute for Social Pediatrics and Adolescent Medicine, Pediatric\n Epidemiology, Ludwig Maximilians University Munich, Munich"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jakob","family":"Armann","sequence":"additional","affiliation":[{"name":"Children\u02bcs Hospital Division of Pediatric Infectious Diseases,\n University Hospital Carl Gustav Carus, Dresden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mathias","family":"Klemme","sequence":"additional","affiliation":[{"name":"Neonatology, Ludwig Maximilians University Munich Faculty of Medicine,\n Munich"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R\u00fcdiger","family":"von Kries","sequence":"additional","affiliation":[{"name":"Institute for Social Pediatrics and Adolescent Medicine, Pediatric\n Epidemiology, Ludwig Maximilians University Munich, Munich"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2020,7,22]]},"reference":[{"key":"ref1","first-page":"1405","article-title":"Prevention of Early-Onset Group B Streptococcal Disease in Newborns","volume":"100","year":"2002","journal-title":"Obstetrics & Gynecology"},{"key":"ref2","first-page":"198","article-title":"Risk factors for early-onset group B streptococcal disease in neonates: a population-based case \u2013 control\n study","volume":"169","author":"C E Adair","year":"2003","journal-title":"CMAJ"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"317","DOI":"10.2471\/BLT.07.050112","article-title":"Revisiting Wilson and Jungner in the genomic age: a review of screening criteria\n over the past 40 years","volume":"86","author":"A Andermann","year":"2008","journal-title":"Bull World Health Organ"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"S133","DOI":"10.1093\/cid\/cix661","article-title":"Preterm Birth Associated With Group B Streptococcus Maternal Colonization\n Worldwide: Systematic Review and Meta-analyses","volume":"65","author":"F Bianchi-Jassir","year":"2017","journal-title":"Clin Infect Dis"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"1665","DOI":"10.1056\/NEJM198606263142603","article-title":"Prevention of early-onset neonatal group B streptococcal disease with selective\n intrapartum chemoprophylaxis","volume":"314","author":"K M Boyer","year":"1986","journal-title":"N Engl J Med"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.ijmm.2005.11.001","article-title":"Epidemiology of Streptococcus agalactiae colonization in Germany","volume":"296","author":"N Brimil","year":"2006","journal-title":"Int J Med Microbiol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1111\/j.1471-0528.1983.tb09280.x","article-title":"The effect of intrapartum chemoprophylaxis on the vertical transmission of group\n B streptococci","volume":"90","author":"C S Easmon","year":"1983","journal-title":"Br J Obstet Gynaecol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"e1139","DOI":"10.1542\/peds.2005-2481","article-title":"Incidence and clinical presentation of invasive neonatal group B streptococcal\n infections in Germany","volume":"117","author":"K Fluegge","year":"2006","journal-title":"Pediatrics"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"608.e1","DOI":"10.1016\/j.ajog.2016.06.021","article-title":"Effect of probiotics on vaginal health in pregnancy. 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