{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,5]],"date-time":"2022-04-05T01:59:24Z","timestamp":1649123964570},"reference-count":9,"publisher":"Georg Thieme Verlag KG","issue":"20","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dtsch Med Wochenschr"],"published-print":{"date-parts":[[2020,10]]},"abstract":"Zusammenfassung<\/jats:title>\n Anamnese und klinischer Befund\u2002Ein 78-j\u00e4hriger Mann erkrankte Anfang April 2020 19 Tage nach einer Kreuzfahrt mit Schw\u00e4che, Husten und Fieber und wurde 4 Tage sp\u00e4ter mit zunehmender Luftnot vorstellig.<\/jats:p>\n Untersuchung und Diagnose\u2002Bei Aufnahme bestanden subfebrile Temperaturen, Belastungsdyspnoe und rechtsbasale Rasselger\u00e4usche. Das CRP war m\u00e4\u00dfig erh\u00f6ht und die Sauerstoffs\u00e4ttigung gering reduziert. Im Thorax-CT fanden sich bilaterale Milchglasinfiltrate. Unmittelbar nach der Kreuzfahrt war ein nasopharyngealer Abstrich auf SARS-CoV-2 negativ.<\/jats:p>\n Therapie und Verlauf\u2002In Kenntnis der Tatsache, dass die symptomfreie Ehefrau des Patienten unmittelbar nach R\u00fcckkehr von der Kreuzfahrt positiv auf SARS-CoV-2 getestet worden war, gingen wir von einer COVID-19-Erkrankung aus und hospitalisierten den Patienten. Zwei nasopharyngeale Abstriche und die Bronchiallavage ergaben negative Befunde f\u00fcr SARS-CoV-2, die Diagnose COVID-19 wurde letztlich serologisch verifiziert.<\/jats:p>\n Folgerung\u2002Bei hochgradigem klinisch-anamnestischem Verdacht in Verbindung mit typischen Befunden der Thorax-Bildgebung sollte die Verdachtsdiagnose COVID-19 auch im Falle mehrfach negativer SARS-CoV-2-PCR aufrechterhalten bleiben. Die Serokonversion tritt einige Tage bis 2 Wochen nach Symptombeginn auf und kann im Verlauf zur endg\u00fcltigen Diagnosesicherung genutzt werden.<\/jats:p>","DOI":"10.1055\/a-1202-3936","type":"journal-article","created":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:06:30Z","timestamp":1598918790000},"page":"1498-1502","source":"Crossref","is-referenced-by-count":0,"title":["Vierfach negative SARS-CoV-2-PCR \u2013 dennoch COVID-19-Pneumonie!"],"prefix":"10.1055","volume":"145","author":[{"given":"Alexandra","family":"Dubbke-Laule","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Innere Medizin, Krankenhaus M\u00e4rkisch-Oderland, Strausberg"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuela","family":"Gnauck","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Innere Medizin, Krankenhaus M\u00e4rkisch-Oderland, Strausberg"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ralf","family":"Straub","sequence":"additional","affiliation":[{"name":"Praxis f\u00fcr Radiologie, Strausberg"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank","family":"Berthold","sequence":"additional","affiliation":[{"name":"IMD Labor Oderland, Frankfurt\/Oder"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Jenssen","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Innere Medizin, Krankenhaus M\u00e4rkisch-Oderland, Strausberg"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2020,8,31]]},"reference":[{"key":"ref2","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1038\/d41586-020-00885-w","article-title":"What the cruise-ship outbreaks reveal about COVID-19","volume":"580","author":"S Mallapaty","year":"2020","journal-title":"Nature"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1080\/22221751.2020.1745095","article-title":"Laboratory diagnosis of emerging human coronavirus infections \u2013 the state of the art","volume":"9","author":"M J Loeffelholz","year":"2020","journal-title":"Emerg Microbes Infect"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"577","DOI":"10.7326\/M20-0504","article-title":"The incubation period of Coronavirus Disease 2019 (COVID-19) from publicly reported confirmed cases: Estimation and application","volume":"172","author":"S A Lauer","year":"2020","journal-title":"Ann Intern Med"},{"key":"ref9","first-page":"264","article-title":"Transmission potential of the novel coronavirus (COVID-19) onboard the Diamond Princess cruises ship","volume":"5","author":"K Mizumoto","year":"2020","journal-title":"Infect Dis Model"},{"key":"ref10","first-page":"10","article-title":"Scha\u0308tzung der aktuellen Entwicklung der SARS-CoV-2-Epidemie in Deutschland \u2013 Nowcasting","volume":"17","author":"M an der Heiden","year":"2020","journal-title":"Epid Bull"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"11875","DOI":"10.1073\/pnas.2006874117","article-title":"The airborne lifetime of small speech droplets and their potential importance in SARS-CoV-2 transmission","volume":"117","author":"V Stadnytskyi","year":"2020","journal-title":"Proc Natl Acad Sci U.S.A"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"108961","DOI":"10.1016\/j.ejrad.2020.108961","article-title":"Diagnosis of the Coronavirus disease (COVID-19): rRT-PCR or CT?","volume":"126","author":"C Long","year":"2020","journal-title":"Eur J Radiol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"101627","DOI":"10.1016\/j.tmaid.2020.101627","article-title":"Clinical diagnostic value of CT imaging in COVID-19 with multiple negative RT","volume":"34","author":"W Hao","year":"2020","journal-title":"Travel Med Infect Dis"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.cca.2020.04.026","article-title":"IgA-Ab response to spike glycoprotein of SARS-CoV-2 in patients with COVID-19: A longitudinal study","volume":"507","author":"A Padoan","year":"2020","journal-title":"Clin Chim Acta"}],"container-title":["DMW - 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