{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T12:19:49Z","timestamp":1792153189794,"version":"4.4.0"},"reference-count":36,"publisher":"Georg Thieme Verlag KG","issue":"05","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Endoscopy"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Background: Data on the long-term outcomes of gastric peroral endoscopic myotomy (G-POEM) for refractory gastroparesis are lacking. We report the results of a large multicenter long-term follow-up study of G-POEM for refractory gastroparesis.<\/jats:p><jats:p>\n          Methods: This was a retrospective multicenter study of all G-POEM operations performed in seven expert French centers for refractory gastroparesis with at least 1 year of follow-up.\u200aThe primary endpoint was the 1-year clinical success rate, defined as at least a 1-point improvement in the Gastroparesis Cardinal Symptom Index (GCSI).<\/jats:p><jats:p>\n          Results: 76 patients were included (60.5\u200a% women; age 56 years). The median symptom duration was 48 months. The median gastric retention at 4 hours (H4) before G-POEM was 45\u200a% (interquartile range [IQR] 29\u200a%\u200a\u2013\u200a67\u200a%). The median GCSI before G-POEM was 3.6 (IQR 2.8\u200a\u2013\u200a4.0). Clinical success was achieved in 65.8\u200a% of the patients at 1 year, with a median rate of reduction in the GCSI score of 41\u200a%. In logistic regression analysis, only a high preoperative GCSI satiety subscale score was predictive of clinical success (odds ratio [OR] 3.41, 95\u200a% confidence interval [CI] 1.01\u200a\u2013\u200a11.54; P\u200a=\u200a0.048), while a high rate of gastric retention at H4 was significantly associated with clinical failure (OR 0.97, 95\u200a%CI 0.95\u200a\u2013\u200a1.00; P\u200a=\u200a0.03).<\/jats:p><jats:p>\n          Conclusions: The results confirm the efficacy of G-POEM for the treatment of refractory gastroparesis, as evidenced by a 65.8\u200a% clinical success rate at 1 year. Although G-POEM is promising, prospective sham-controlled trials are urgently needed to confirm its efficacy and identify the patient populations who will benefit most from this procedure.<\/jats:p>","DOI":"10.1055\/a-1205-5686","type":"journal-article","created":{"date-parts":[[2020,6,23]],"date-time":"2020-06-23T23:29:32Z","timestamp":1592954972000},"page":"480-490","source":"Crossref","is-referenced-by-count":48,"title":["One-year results of gastric peroral endoscopic myotomy for refractory gastroparesis: a French multicenter study"],"prefix":"10.1055","volume":"53","clinical-trial-number":[{"clinical-trial-number":"nct04024709","registry":"10.18810\/clinical-trials-gov"}],"author":[{"given":"Olivier","family":"Ragi","sequence":"first","affiliation":[{"name":"Service de gastroent\u00e9rologie, CHU Limoges, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00e9r\u00e9mie","family":"Jacques","sequence":"first","affiliation":[{"name":"Service de gastroent\u00e9rologie, CHU Limoges, France"},{"name":"CNRS, XLIM, UMR 7252, Limoges, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julien","family":"Branche","sequence":"additional","affiliation":[{"name":"Service de gastroent\u00e9rologie, CHU Claude Huriez, Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Leblanc","sequence":"additional","affiliation":[{"name":"Service de gastroent\u00e9rologie, APHP, H\u00f4pital Cochin, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geoffroy","family":"Vanbiervliet","sequence":"additional","affiliation":[{"name":"Service de gastroent\u00e9rologie, CHU L\u2019Archet 2, Nice, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Romain","family":"Legros","sequence":"additional","affiliation":[{"name":"Service de gastroent\u00e9rologie, CHU Limoges, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathieu","family":"Pioche","sequence":"additional","affiliation":[{"name":"Service de gastroent\u00e9rologie, HCL Edouard Herriot, Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00e9r\u00f4me","family":"Rivory","sequence":"additional","affiliation":[{"name":"Service de gastroent\u00e9rologie, HCL Edouard Herriot, Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stanislas","family":"Chaussade","sequence":"additional","affiliation":[{"name":"Service de gastroent\u00e9rologie, APHP, H\u00f4pital Cochin, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maximilien","family":"Barret","sequence":"additional","affiliation":[{"name":"Service de gastroent\u00e9rologie, APHP, H\u00f4pital Cochin, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timoth\u00e9e","family":"Wallenhorst","sequence":"additional","affiliation":[{"name":"Service de gastroent\u00e9rologie, CHU Pontchailloux, Rennes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Barthet","sequence":"additional","affiliation":[{"name":"Service de gastroent\u00e9rologie, APHM, H\u00f4pital Nord, Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00e9bastien","family":"Kerever","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Critical Care, Saint Louis Lariboisi\u00e8re Fernand Widal University Hospital, AP-HP, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Michel","family":"Gonzalez","sequence":"additional","affiliation":[{"name":"Service de gastroent\u00e9rologie, APHM, H\u00f4pital Nord, Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2020,7,21]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1038\/ajg.2012.373","article-title":"American College of Gastroenterology. 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