{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T00:00:00Z","timestamp":1784764800394,"version":"3.55.0"},"reference-count":30,"publisher":"Georg Thieme Verlag KG","issue":"03","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Z Geburtshilfe Neonatol"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n                    Introduction Recent studies have addressed the role of micronutrients in\n                    fertilization, such as vitamin D. The present study aims to explore the effects\n                    of using calcitriol, an active form of vitamin D, on IVF results in women with\n                    vitamin D deficiency.<\/jats:p><jats:p>\n                    Method This double-blinded randomized clinical trial was done on 180\n                    infertile women, undergone IVF treatment. Out of them, 95 were found to have\n                    vitamin D deficiency (blood serum 25-dihydroxy vitamin D &lt;30\n                    ng\/ml). Fifty one women in experimental group were treated with two 0.25\n                    \u00b5g calcitriol pills daily during 4 weeks (discontinued 8 hours prior to\n                    the embryo transfer) and 44 subjects to the placebo group (mean vitamin D\n                    deficiency 27.5 \u00b11.8 in case group vs. 27.6\u00b11.8 in control\n                    group, P&gt;0.05). Final analysis includes outcomes of chemical and\n                    clinical pregnancy was done on 74 women (including 36 in case and 38 in control\n                    group).<\/jats:p><jats:p>\n                    Results Our study showed that in the experimental group, chemical\n                    pregnancy success was significantly higher than that in the control group, 31.4\n                    vs. 18.2% (P&lt;0.05). However, there were no significant\n                    differences between the 2 groups in reaching the clinical pregnancy stage\n                    (25.5% in case group vs. 13.6% in control group) and\n                    continuation of pregnancy into week 20 (9.8% in case group vs.\n                    11.6% in control group) (P&gt;0.05).<\/jats:p><jats:p>\n                    Conclusion Calcitriol administration by improving the implantation\n                    process can significantly increase the chances of successful IVF cycle results\n                    in infertile women with vitamin D deficiency.<\/jats:p>","DOI":"10.1055\/a-1206-1064","type":"journal-article","created":{"date-parts":[[2020,9,14]],"date-time":"2020-09-14T22:43:38Z","timestamp":1600123418000},"page":"226-231","source":"Crossref","is-referenced-by-count":18,"title":["Calcitriol Effect on Outcomes of in Vitro Fertilization in Infertile\n                    Women with Vitamin D Deficiency: A Double-Blind Randomized Clinical\n                    Trial"],"prefix":"10.1055","volume":"225","author":[{"given":"Leila","family":"Doryanizadeh","sequence":"additional","affiliation":[{"name":"Department of Midwifery, School of Nursing and Midwifery, Shiraz\n                    University of Medical Sciences, Shiraz, Iran (the Islamic Republic\n                    of)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bahar","family":"Morshed-Behbahani","sequence":"additional","affiliation":[{"name":"Department of Midwifery, School of Nursing and Midwifery, Shiraz\n                    University of Medical Sciences, Shiraz, Iran (the Islamic Republic\n                    of)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Ebrahim","family":"Parsanezhad","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics, Medical School, Shiraz\n                    University of Medical Sciences, Shiraz, Iran (the Islamic Republic\n                    of)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Hossein","family":"Dabbaghmanesh","sequence":"additional","affiliation":[{"name":"Shiraz endocrine research center, Shiraz University of Medical\n                    Sciences, Shiraz, Iran (the Islamic Republic of)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Azam","family":"Jokar","sequence":"additional","affiliation":[{"name":"Department of Midwifery, School of Nursing and Midwifery, Shiraz\n                    University of Medical Sciences, Shiraz, Iran (the Islamic Republic\n                    of)"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2020,9,14]]},"reference":[{"key":"ref1","first-page":"382","article-title":"The experiences of infertile women on assistant reproductive treatments: a\n                    phenomenological study","volume":"14","author":"B 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and early pregnancy loss","volume":"7","author":"AA R Sharef","year":"2020","journal-title":"Middle East J Fam Med"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.ejogrb.2011.07.006","article-title":"Predictive value of the level of vitamin D in follicular fluid on the outcome of\n                    assisted reproductive technology","volume":"159","author":"A Aleyasin","year":"2011","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"1851","DOI":"10.1017\/S1368980015001925","article-title":"Vitamin D deficiency and its associated risk factors in children and adolescents\n                    in southern Iran","volume":"20","author":"F Saki","year":"2017","journal-title":"Public Health Nutr"},{"key":"ref19","first-page":"125","article-title":"High prevalence of vitamin D deficiency among Iranian population: a systematic\n                    review and meta-analysis","volume":"43","author":"R 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Open"},{"key":"ref23","first-page":"18","article-title":"Effect of vitamin D supplementation on intracytoplasmic sperm injection\n                    outcomes: a randomized double-blind placebo-controlled trial","volume":"13","author":"S Abedi","year":"2019","journal-title":"Int J Fertil Steril"},{"key":"ref24","first-page":"300","article-title":"Histological evaluation of vitamin-D deficiency on the endometrial\n                    decidualization in early pregnancy in rat model","volume":"41","author":"SS Kamar","year":"2018","journal-title":"Egypt J Histol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"1608","DOI":"10.1016\/j.fertnstert.2014.08.030","article-title":"Impact of circulating levels of total and bioavailable serum vitamin D on\n                    pregnancy rate in egg donation recipients","volume":"102","author":"A Fabris","year":"2014","journal-title":"Fertil Steril"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"117","DOI":"10.3109\/14767058.2016.1163680","article-title":"Association of vitamin D with outcome after intra cytoplasmic sperm\n                    injection","volume":"30","author":"U H Abdullah","year":"2017","journal-title":"J Matern Fetal Neonatal Med"},{"key":"ref28","first-page":"595","article-title":"Effect of vitamin D insufficiency treatment on fertility outcomes in\n                    frozen-thawed embryo transfer cycles: a randomized clinical trial","volume":"12","author":"A Aflatoonian","year":"2014","journal-title":"Iran J Reprod Med"},{"issue":"315","key":"ref29","first-page":"e1","article-title":"Vitamin D levels do not affect IVF outcomes following the transfer of euploid\n                    blastocysts","volume":"212","author":"J M Franasiak","year":"2015","journal-title":"Am J Obstet Gynecol"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"E2372","DOI":"10.1210\/jc.2014-1802","article-title":"Vitamin D deficiency and infertility: insights from in vitro fertilization\n                    cycles","volume":"99","author":"A Paffoni","year":"2014","journal-title":"J Clin Endocrinol Metab"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"79","DOI":"10.4103\/jhrs.JHRS_117_16","article-title":"Vitamin D deficiency does not influence reproductive outcomes of IVF-ICSI: A\n                    study of oocyte donors and recipients","volume":"10","author":"M Banker","year":"2017","journal-title":"J Hum Reprod Sci"}],"container-title":["Zeitschrift f\u00fcr Geburtshilfe und Neonatologie"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-1206-1064.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,6,23]],"date-time":"2021-06-23T22:37:46Z","timestamp":1624487866000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-1206-1064"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9,14]]},"references-count":30,"journal-issue":{"issue":"03","published-online":{"date-parts":[[2021,6,23]]},"published-print":{"date-parts":[[2021,6]]}},"URL":"https:\/\/doi.org\/10.1055\/a-1206-1064","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0948-2393","1439-1651"],"issn-type":[{"value":"0948-2393","type":"print"},{"value":"1439-1651","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,9,14]]}}}