{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T10:01:46Z","timestamp":1790676106798,"version":"4.1.0"},"reference-count":45,"publisher":"Georg Thieme Verlag KG","issue":"04","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tierarztl Prax Ausg G Grosstiere Nutztiere"],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title><jats:p>Ziel Untersuchung von Zusammenh\u00e4ngen zwischen der Haptoglobinkonzentration im Blut und dem Auftreten einer Ketose, ausgew\u00e4hlten klinischen Parametern und Lahmheit bei Milchk\u00fchen.<\/jats:p><jats:p>Material und Methoden Die Datenerhebung fand in 39 bayerischen Milchviehbetrieben \u00fcber 8 Monate statt. Bei den einbezogenen 712 Fleckvieh- und Braunviehk\u00fchen, deren Kalbung 10\u201330 Tage zur\u00fccklag, wurde eine klinische Untersuchung durchgef\u00fchrt sowie eine Milch- und eine Blutprobe entnommen. Im Blut wurden die Konzentrationen von freien Fetts\u00e4uren (non-esterified fatty acids, NEFA), \u03b2-Hydroxybutyrat (BHB) und Haptoglobin (Hp) bestimmt, in der Milch die Milchinhaltsstoffe (Fett, Eiwei\u00df, Harnstoff, Laktose, Azeton), BHB, NEFA und die somatische Zellzahl (SCC).<\/jats:p><jats:p>Ergebnisse Signifikante Korrelationen ergaben sich zwischen erh\u00f6hten Hp-Konzentrationen einerseits und erh\u00f6hten NEFA-Konzentrationen in Blut und Milch (p &lt; 0,001), erh\u00f6hter SCC (p &lt; 0,001), Lahmheit (p &lt; 0,001), vermindertem Laktosegehalt (p &lt; 0,001) sowie vermindertem Proteingehalt der Milch (p = 0,001) andererseits. In den w\u00e4rmeren Sommermonaten beprobte Tiere hatten signifikant h\u00f6here Hp-Konzentrationen (p &lt; 0,001). Erstkalbinnen wiesen signifikant h\u00f6here Hp-Werte auf als multipare Tiere (p &lt; 0,001). Durch die Einteilung der Tiere in 4 Cluster lie\u00df sich ein Hp-Grenzwert bestimmen, der 0,18 mg\/ml betrug. Kombiniert mit einem SCC-Grenzwert von 40 500 Zellen\/ml Milch konnte der Gro\u00dfteil der subklinisch und klinisch auff\u00e4lligen Tiere ermittelt werden.<\/jats:p><jats:p>Schlussfolgerung und klinische Relevanz Die Messung der Hp-Konzentration im Blut stellt einen praktikablen Ansatz zur Unterst\u00fctzung des Tiergesundheitsmonitorings im postpartalen Zeitraum dar. Zusammen mit der Auswertung der Milchmenge und der Milchinhaltsstoffe k\u00f6nnen Abweichungen von physiologischen Zust\u00e4nden erkannt und betroffene Tiere zeitnah behandelt werden. Haptoglobin kann f\u00fcr die Bewertung des Gesundheitsstatus des Einzeltieres wie auch als Indikator f\u00fcr die Herdengesundheit genutzt werden.<\/jats:p>","DOI":"10.1055\/a-1208-8229","type":"journal-article","created":{"date-parts":[[2020,8,21]],"date-time":"2020-08-21T22:49:22Z","timestamp":1598050162000},"page":"228-238","source":"Crossref","is-referenced-by-count":3,"title":["Nutzung der Haptoglobinkonzentration im Blutserum als Indikator im Tiergesundheitsmonitoring bei Milchk\u00fchen"],"prefix":"10.1055","volume":"48","author":[{"given":"Franziska","family":"Hajek","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Wiederk\u00e4uer mit Ambulanz und Bestandsbetreuung, Tier\u00e4rztliche Fakult\u00e4t der Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Reus","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Wiederk\u00e4uer mit Ambulanz und Bestandsbetreuung, Tier\u00e4rztliche Fakult\u00e4t der Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone","family":"Gruber","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Wiederk\u00e4uer mit Ambulanz und Bestandsbetreuung, Tier\u00e4rztliche Fakult\u00e4t der Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Plattner","sequence":"additional","affiliation":[{"name":"Milchpr\u00fcfring Bayern e. V."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Kammer","sequence":"additional","affiliation":[{"name":"Landeskuratorium der Erzeugerringe f\u00fcr tierische Veredelung in Bayern e. V."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Baumgartner","sequence":"additional","affiliation":[{"name":"Milchpr\u00fcfring Bayern e. V."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moniek","family":"Smink","sequence":"additional","affiliation":[{"name":"School of Veterinary Medicine, University of Wisconsin-Madison"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D\u00f6rte","family":"D\u00f6pfer","sequence":"additional","affiliation":[{"name":"School of Veterinary Medicine, University of Wisconsin-Madison"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabrina","family":"Hachenberg","sequence":"additional","affiliation":[{"name":"Deutscher Verband f\u00fcr Leistungs- und Qualit\u00e4tspr\u00fcfungen e. V."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rolf","family":"Mansfeld","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Wiederk\u00e4uer mit Ambulanz und Bestandsbetreuung, Tier\u00e4rztliche Fakult\u00e4t der Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2020,8,21]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"5878","DOI":"10.3168\/jds.2010-3391","article-title":"Associations of prepartum plasma cortisol, haptoglobin, fecal cortisol metabolites, and nonesterified fatty acids with postpartum health status in Holstein dairy cows","volume":"94","author":"J M Huzzey","year":"2011","journal-title":"J Dairy Sci"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3168\/jds.S0022-0302(82)82146-2","article-title":"Primary ketosis in the high-producing dairy cow: Clinical and subclinical disorders, treatment, prevention, and outlook","volume":"65","author":"G D Baird","year":"1982","journal-title":"J Dairy Sci"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1292\/jvms.64.293","article-title":"Relevance of apolipoproteins in the development of fatty liver and fatty liverrelated peripartum diseases in dairy cows","volume":"64","author":"N Katoh","year":"2002","journal-title":"J Vet Med Sci"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"4439","DOI":"10.3168\/jds.2008-1632","article-title":"Short communication: Relationship between metabolic status and the milk concentrations of haptoglobin and lactoferrin in dairy cows during early lactation","volume":"92","author":"S Hiss","year":"2009","journal-title":"J Dairy Sci"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"5045","DOI":"10.3168\/jds.2011-4415","article-title":"Effect of mobility score on milk yield and activity in dairy cattle","volume":"94","author":"J D Reader","year":"2011","journal-title":"J Dairy Sci"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1136\/vr.144.16.437","article-title":"Acute phase proteins in cattle: Discrimination between acute and chronic inflammation","volume":"144","author":"N U Horadagoda","year":"1999","journal-title":"Vet Rec"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1007\/BF00362798","article-title":"Bovine and canine acute phase proteins","volume":"12","author":"P D Eckersall","year":"1988","journal-title":"Vet Res Commun"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0165-2427(95)05454-E","article-title":"Validation of immunoassays for bovine haptoglobin","volume":"49","author":"C R Young","year":"1995","journal-title":"Vet Immunol Immunopathol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"4207","DOI":"10.1016\/j.jprot.2012.04.004","article-title":"Acute phase proteins in ruminants","volume":"75","author":"F Ceciliani","year":"2012","journal-title":"J Proteomics"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.vetimm.2012.03.011","article-title":"Bovine haptoglobin as an adipokine: serum concentrations and tissue expression in dairy cows receiving a conjugated linoleic acids supplement throughout lactation","volume":"146","author":"B Saremi","year":"2012","journal-title":"Vet Immunol Immunopathol"},{"key":"ref11","first-page":"505","article-title":"Haptoglobin bei Hauss\u00e4ugetieren. III. Der Haptoglobingehalt im Blutplasma und-serum von Wiederk\u00e4uern und Schweinen unter verschiedenen physiologischen Bedingungen","volume":"28","author":"H Richter","year":"1974","journal-title":"Arch Exp Veterinarmed"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"621","DOI":"10.3168\/jds.2008-1526","article-title":"Short communication: Haptoglobin as an early indicator of metritis","volume":"92","author":"J M Huzzey","year":"2009","journal-title":"J Dairy Sci"},{"key":"ref13","first-page":"76","article-title":"Erkennen von subklinisch und klinisch erkrankten Milchk\u00fchen mit Hilfe des Gesundheitsmonitorings aus der Rohmilch","volume":"17","author":"A H\u00f6hmann","year":"2017","journal-title":"Tagungsband AVA Haupttagung"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"245","DOI":"10.17221\/1879-VETMED","article-title":"Haptoglobin and lactate dehydrogenase measurements in milk for the identification of subclinically diseased udder quarters","volume":"52","author":"S Hiss","year":"2007","journal-title":"Veterinari Medicina"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1111\/j.1939-165X.2006.tb00112.x","article-title":"Relationship between haptoglobin, serum amyloid A, and clinical status in a survey of dairy herds during a 6-month period","volume":"35","author":"M-F Humblet","year":"2006","journal-title":"Vet Clin Pathol"},{"key":"ref16","first-page":"240","article-title":"Dynamik des Akute-Phase-Proteins Haptoglobin bei Rindern mit Spontangeburten und solchen mit Schnittentbindungen mit oder ohne Torsio uteri intra partum","volume":"118","author":"A Sch\u00f6nfelder","year":"2005","journal-title":"Berl Munch Tierarztl Wochenschr"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"3758","DOI":"10.3168\/jds.2007-0052","article-title":"Treatment of acute puerperal metritis with flunixin meglumine in addition to antibiotic treatment","volume":"90","author":"M Drillich","year":"2007","journal-title":"J Dairy Sci"},{"key":"ref18","first-page":"1","volume-title":"Allgemeiner klinischer Untersuchungsgang","author":"W Baumgartner","year":"2009"},{"key":"ref19","first-page":"145","article-title":"A novel scoring system for monitoring the relationship between nutritional efficiency and fertility in dairy cows","volume":"56","author":"D Zaaijer","year":"2003","journal-title":"Ir Vet J"},{"key":"ref20","first-page":"288","volume-title":"Verdauungsapparat","author":"G Dirksen","year":"1990"},{"key":"ref21","volume-title":"Rinderskript","author":"W Klee","year":"2016"},{"key":"ref22","first-page":"467","article-title":"Energie- und Fettstoffwechsel des Rindes Untersuchungskonzept und Messung der R\u00fcckenfettdicke","volume":"47","author":"R Staufenbiel","year":"1992","journal-title":"Monatsh Veterinarmed"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1016\/S0093-691X(97)00098-8","article-title":"A lameness scoring system that uses posture and gait to predict dairy cattle reproductive performance","volume":"14","author":"D J Sprecher","year":"1997","journal-title":"Theriogenology"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"2925","DOI":"10.3168\/jds.2012-6035","article-title":"Prevalence of subclinical ketosis and relationships with postpartum diseases in European dairy cows","volume":"96","author":"V S Suthar","year":"2013","journal-title":"J Dairy Sci"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"7311","DOI":"10.3168\/jds.2017-13582","article-title":"Identifying poor metabolic adaptation during early lactation in dairy cows using cluster analysis","volume":"101","author":"M Tremblay","year":"2018","journal-title":"J Dairy Sci"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1055\/s-0038-1623149","article-title":"Vergleichende Betrachtung ausgew\u00e4hlter Blutparameter von Hochleistungsk\u00fchen bei unterschiedlichen Entnahmestellen","volume":"41","author":"K Wilhelm","year":"2013","journal-title":"Tier\u00e4rztliche Praxis Ausgabe G: Gro\u00dftiere\/Nutztiere"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"2145","DOI":"10.3168\/jds.2013-7163","article-title":"A field study to determine the prevalence, dairy herd management systems, and fresh cow clinical conditions associated with ketosis in western European dairy herds","volume":"97","author":"A C Berge","year":"2014","journal-title":"J Dairy Sci"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"431","DOI":"10.24099\/vet.arhiv.160126c","article-title":"Biomarkers of ketosis in dairy cows at postparturient period: Acute phase proteins and pro-inflammatory cytokines","volume":"87","author":"W M El-Deeb","year":"2017","journal-title":"Veterinarski arhiv"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.rvsc.2016.09.015","article-title":"Inflammatory biomarkers are associated with ketosis in periparturient Holstein cows","volume":"109","author":"M Abuajamieh","year":"2016","journal-title":"Res Vet Sci"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"6011","DOI":"10.3168\/jds.2011-4463","article-title":"A field trial on the effect of propylene glycol on milk yield and resolution of ketosis in fresh cows diagnosed with subclinical ketosis","volume":"94","author":"J AA McArt","year":"2011","journal-title":"J Dairy Sci"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.14202\/vetworld.2016.1204-1208","article-title":"Acute phase response in lame crossbred dairy cattle","volume":"9","author":"A Bagga","year":"2016","journal-title":"Vet World"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.tvjl.2009.08.012","article-title":"Serum haptoglobin concentrations in dairy cattle with lameness due to claw disorders","volume":"186","author":"B I Smith","year":"2010","journal-title":"The Veterinary Journal"},{"key":"ref34","first-page":"444","article-title":"Locomotion scoring and lameness detection in dairy cattle","volume":"24","author":"H Whay","year":"2002","journal-title":"Farm Anim Pract"},{"key":"ref35","first-page":"95","article-title":"Evaluation of serum haptoglobin in clinically healthy cattle and cattle with inflammatory diseases in Shiraz, a tropical area in southern Iran","volume":"11","author":"S Nazifi","year":"2008","journal-title":"Bulgarian Journal of Veterinary Medicine"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1186\/BF03547039","article-title":"Acute phase response in dairy cows with experimentally induced Escherichia coli mastitis","volume":"40","author":"J Hirvonen","year":"1999","journal-title":"Acta Vet Scand"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/S0034-5288(96)90138-1","article-title":"Quantitative determination of bovine serum haptoglobin in experimentally induced Escherichia coli mastitis","volume":"60","author":"M Salonen","year":"1996","journal-title":"Res Vet Sci"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/1751-0147-50-18","article-title":"Acute phase response in two consecutive experimentally induced E. coli intramammary infections in dairy cows","volume":"50","author":"L Suojala","year":"2008","journal-title":"Acta Vet Scand"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1017\/S0022029909990185","article-title":"Haptoglobin and serum amyloid A in bulk tank milk in relation to raw milk quality","volume":"76","author":"M \u00c5kerstedt","year":"2009","journal-title":"J Dairy Res"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1016\/j.idairyj.2008.01.002","article-title":"Relationship between haptoglobin and serum amyloid A in milk and milk quality","volume":"18","author":"M \u00c5kerstedt","year":"2008","journal-title":"Int Dairy J"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"644","DOI":"10.3168\/jds.2009-2295","article-title":"Effects of heat stress on energetic metabolism in lactating Holstein cows","volume":"93","author":"J B Wheelock","year":"2010","journal-title":"J Dairy Sci"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"2131","DOI":"10.3168\/jds.S0022-0302(03)73803-X","article-title":"Effects of heat-stress on production in dairy cattle","volume":"86","author":"J W West","year":"2003","journal-title":"J Dairy Sci"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"3028","DOI":"10.3168\/jds.2012-5737","article-title":"Short communication: Comparison of the effects of heat stress on milk and component yields and somatic cell score in Holstein and Jersey cows","volume":"96","author":"D L Smith","year":"2013","journal-title":"J Dairy Sci"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"1844","DOI":"10.3168\/jds.2012-5947","article-title":"Evaluation of heat stress effects on production traits and somatic cell score of Holsteins in a temperate environment","volume":"96","author":"H Hammami","year":"2013","journal-title":"J Dairy Sci"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"2766","DOI":"10.3168\/jds.S0022-0302(90)78962-X","article-title":"Influence of breed of fetus on periparturient endocrine responses and subsequent milk production of Ayrshire Dams","volume":"73","author":"L A Guilbault","year":"1990","journal-title":"J Dairy Sci"},{"key":"ref46","volume-title":"Untersuchung von Blutparametern bei Jungrindern der Rassen Deutsche Holsteins und Deutsches Braunvieh","author":"C N Berry","year":"2005"}],"container-title":["Tier\u00e4rztliche Praxis Ausgabe G: Gro\u00dftiere \/ 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