{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T16:29:32Z","timestamp":1782491372068,"version":"3.54.5"},"reference-count":42,"publisher":"Georg Thieme Verlag KG","issue":"01\/02","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Planta Med"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Two new diterpenoid derivatives 7\u03b1,12\u03b2,17-triacetoxy-6\u03b2,19-dihydroxy-13\u03b2,16-spirocicloabiet-8-ene-11,14-dione (1) and 6\u03b2-acetoxy-3\u03b2,7\u03b1,12\u03b1-trihydroxy-13\u03b2,16-spirocicloabiet-8-ene-11,14-dione (2) along with 11 (3\u201313) miscellaneous compounds were isolated from the leaves of Plectranthus ornatus Codd. Their structures were elucidated by spectroscopic analysis and gauge independent atomic orbitals 13C NMR calculations. The isolated compounds were screened for their effects on intestinal motility using guinea-pig ileum and duodenum and by their cytotoxicity against 4 human cancer cell lines (HCT-116, SF-295, PC-3, and HL-60). Compounds 6 and 9 were moderately cytotoxic against HL-60, whereas 6 and 13 were more active on SF-295 and HCT-116.<\/jats:p>","DOI":"10.1055\/a-1209-3252","type":"journal-article","created":{"date-parts":[[2020,8,3]],"date-time":"2020-08-03T22:54:58Z","timestamp":1596495298000},"page":"124-135","source":"Crossref","is-referenced-by-count":8,"title":["Diterpenoids from Leaves of Cultivated Plectranthus ornatus"],"prefix":"10.1055","volume":"87","author":[{"given":"Lidiv\u00e2nia Silva Freitas","family":"Mesquita","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica Org\u00e2nica e Inorg\u00e2nica, Universidade Federal do Cear\u00e1, Fortaleza-CE, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taynara Sim\u00e3o","family":"Matos","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica Org\u00e2nica e Inorg\u00e2nica, Universidade Federal do Cear\u00e1, Fortaleza-CE, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F\u00e1bio do Nascimento","family":"\u00c1vila","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica Org\u00e2nica e Inorg\u00e2nica, Universidade Federal do Cear\u00e1, Fortaleza-CE, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alison da Silva","family":"Batista","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica Org\u00e2nica e Inorg\u00e2nica, Universidade Federal do Cear\u00e1, Fortaleza-CE, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9a Felinto","family":"Moura","sequence":"additional","affiliation":[{"name":"N\u00facleo de Pesquisa e Desenvolvimento de Medicamentos, Universidade Federal do Cear\u00e1, Fortaleza-CE, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manoel Odorico","family":"de Moraes","sequence":"additional","affiliation":[{"name":"N\u00facleo de Pesquisa e Desenvolvimento de Medicamentos, Universidade Federal do Cear\u00e1, Fortaleza-CE, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matheus Carlos Matos","family":"da Silva","sequence":"additional","affiliation":[{"name":"Instituto Superior de Ci\u00eancias Biom\u00e9dicas, Universidade Estadual do Cear\u00e1, Fortaleza-CE, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Talles Luann Abrantes","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Instituto Superior de Ci\u00eancias Biom\u00e9dicas, Universidade Estadual do Cear\u00e1, Fortaleza-CE, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nilberto Robson Falc\u00e3o","family":"Nascimento","sequence":"additional","affiliation":[{"name":"Instituto Superior de Ci\u00eancias Biom\u00e9dicas, Universidade Estadual do Cear\u00e1, Fortaleza-CE, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norberto K\u00e1ssio Vieira","family":"Monteiro","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica Anal\u00edtica e F\u00edsico-Qu\u00edmica, Universidade Federal do Cear\u00e1, Fortaleza-CE, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ot\u00edlia Deusd\u00eania Loiola","family":"Pessoa","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica Org\u00e2nica e Inorg\u00e2nica, Universidade Federal do Cear\u00e1, Fortaleza-CE, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2020,8,3]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jep.2005.09.011","article-title":"Plectranthus: a review of ethnobotanical uses","volume":"103","author":"C W Lukhoba","year":"2006","journal-title":"J Ethnopharmacol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1016\/j.sajb.2011.07.001","article-title":"Plectranthus: A 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