{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T18:16:33Z","timestamp":1761156993603},"reference-count":75,"publisher":"Georg Thieme Verlag KG","issue":"04","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hamostaseologie"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The characterization of platelet concentrates (PCs) in transfusion medicine has been performed with different analytical methods and platelet lesions (from biochemistry to cell biology) have been documented. In routine quality assessment and validation of manufacturing processes of PCs for transfusion purposes, only basic parameters are monitored and the platelet functions are not included. However, PCs undergo several manipulations during the processing and the basic parameters do not provide sensitive analyses to properly picture out the impact of the blood component preparation and storage on platelets. To improve the transfusion supply chain and the platelet functionalities, additional parameters should be used. The present short review will focus on the different techniques to monitor ex vivo platelet lesions from phenotype characterization to advanced omic analyses. Then, the opportunities to use these methods in quality control, process validation, development, and research will be discussed. Functional markers should be considered because they would be an advantage for the future developments in transfusion medicine.<\/jats:p>","DOI":"10.1055\/a-1210-3229","type":"journal-article","created":{"date-parts":[[2020,9,15]],"date-time":"2020-09-15T23:04:58Z","timestamp":1600211098000},"page":"500-508","source":"Crossref","is-referenced-by-count":8,"title":["What about Platelet Function in Platelet Concentrates?"],"prefix":"10.1055","volume":"40","author":[{"given":"Michel","family":"Prudent","sequence":"additional","affiliation":[{"name":"Laboratoire de Recherche sur les Produits Sanguins, Recherche et D\u00e9veloppement Produits, Transfusion Interr\u00e9gionale CRS, Epalinges, Switzerland"},{"name":"Centre de transfusion Sanguine, Facult\u00e9 de Biologie et de M\u00e9decine, University of Lausanne, Lausanne, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2020,9,15]]},"reference":[{"issue":"02","key":"ref1","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.transci.2009.07.002","article-title":"The platelet storage lesion","volume":"41","author":"M Shrivastava","year":"2009","journal-title":"Transfus Apheresis Sci"},{"issue":"03","key":"ref2","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.tracli.2017.05.012","article-title":"The storage lesions: from past to future","volume":"24","author":"J D Tissot","year":"2017","journal-title":"Transfus Clin Biol"},{"key":"ref3","volume-title":"Guide to the Preparation, Use and Quality Assurance of Blood Components","author":"EDQM","year":"2017","edition":"19th ed."},{"issue":"02","key":"ref4","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1159\/000487513","article-title":"Platelet additive solutions: a review of the latest developments and 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