{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,7,18]],"date-time":"2024-07-18T00:50:23Z","timestamp":1721263823204},"reference-count":16,"publisher":"Georg Thieme Verlag KG","issue":"03","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dtsch Med Wochenschr"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:title>Was ist neu?<\/jats:title><jats:p>\n          Klinische Manifestation eines B-Vitamin-Mangels\u2002Ein Vitamin-B1-Mangel kann sich als Wernicke-Enzephalopathie oder als Beriberi manifestieren. Geriatrische Patienten mit den Diagnosen \nDemenz oder Delir haben niedrigere Vitamin-B1-Spiegel als solche ohne diese Diagnosen. Ebenso zeigen sich bei geriatrischen Patienten mit h\u00f6herem Vitamin-B1-Spiegel bessere Ergebnisse in der Funktionalit\u00e4t (Barthel-Index) bei Entlassung. Vitamin B6 ist an \u00fcber 100 Reaktionen als Koenzym beteiligt und ein Mangel kann daher mit vielen Symptomen einhergehen. Klinische Manifestationen des Vitamin-B12-Mangels reichen von fr\u00fchen neuropsychiatrischen bis zu h\u00e4matologischen Symptomen, wobei die makrozyt\u00e4re An\u00e4mie als sp\u00e4ter Indikator eines Vitamin-B12-Mangels gilt. Neurologische Symptome treten sehr h\u00e4ufig schon vor oder ohne h\u00e4matologische Manifestationen auf.<\/jats:p><jats:p>\n          Diagnostik von B-Vitamin-Mangelzust\u00e4nden\u2002Die Bestimmung des Vitamin-B1-Spiegels im Blut ist wenig aussagekr\u00e4ftig. Die Wernicke-Enzephalopathie ist eine klinische Diagnose. Zur Diagnose eines Vitamin-B6-Mangels wird die Bestimmung von Pyridoxin (Pyridoxal-5\u2032-Phosphat) im Plasma empfohlen. Ein erniedrigter Holo-TC-Spiegel im Serum gilt als fr\u00fchester Marker eines Vitamin-B12-Mangels. Eine kombinierte Bestimmung von Vitamin B12, Holo-TC, MMA und Homozystein scheint die diagnostische Zuverl\u00e4ssigkeit bei Vitamin-B12-Mangel zu erh\u00f6hen.<\/jats:p><jats:p>\n          Therapie\u2002F\u00fcr Empfehlungen zur Substitutionstherapie bei allen B-Vitaminen liegen kaum bzw. keine evidenzbasierten Daten vor. Durch die Substitution von 0,8\u200amg Fols\u00e4ure, 0,5\u200amg Vitamin B12 und 20\u200amg Vitamin B6 konnte in einer randomisierten kontrollierten Studie bei Patienten mit einer leichten kognitiven St\u00f6rung eine Verlangsamung der Hirnatrophie bewirkt werden.<\/jats:p>","DOI":"10.1055\/a-1210-5030","type":"journal-article","created":{"date-parts":[[2021,1,29]],"date-time":"2021-01-29T23:31:34Z","timestamp":1611963094000},"page":"152-156","source":"Crossref","is-referenced-by-count":3,"title":["B-Vitamine in der Geriatrie \u2013 was bestimmen, was\u00a0ersetzen?"],"prefix":"10.1055","volume":"146","author":[{"given":"Marija","family":"Djukic","sequence":"additional","affiliation":[{"name":"Abteilung f\u00fcr Geriatrie, Evangelisches Krankenhaus Weende"},{"name":"Institut f\u00fcr Neuropathologie, Universit\u00e4tsmedizin G\u00f6ttingen"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christine A.F.","family":"von Arnim","sequence":"additional","affiliation":[{"name":"Abteilung f\u00fcr Geriatrie, Universit\u00e4tsmedizin G\u00f6ttingen"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2021,1,29]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1159\/000508618","article-title":"German Nutrition Society (DGE). 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