{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,27]],"date-time":"2024-08-27T06:10:15Z","timestamp":1724739015218},"reference-count":49,"publisher":"Georg Thieme Verlag KG","issue":"04","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Laryngorhinootologie"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title><jats:p>Hintergrund\u2002Sinunasale Papillome sind Tumoren der Nasenhaupt- und Nasennebenh\u00f6hlen. Therapie der Wahl ist die vollst\u00e4ndige Resektion unter tumorchirurgischen Kautelen. Zwei Eigenschaften machen die Tumornachsorge zu einer Herausforderung: Erstens die h\u00e4ufige Rezidiv-Entwicklung (auch viele Jahre nach Erstdiagnose) und zweitens die M\u00f6glichkeit der malignen Entartung. Diese \u00dcbersichtsarbeit beleuchtet diesbez\u00fcgliche Risikofaktoren, um \u201eHochrisikopatienten\u201c zu identifizieren, die in der Tumornachsorge besondere Aufmerksamkeit verdienen.<\/jats:p><jats:p>Materialen und Methoden\u2002Es erfolgte eine ausf\u00fchrliche Literaturrecherche in PubMed (NCBI).<\/jats:p><jats:p>Ergebnisse\u2002Hauptrisikofaktor f\u00fcr Rezidive ist die unvollst\u00e4ndige Tumorresektion. Daraus ergeben sich weitere Faktoren wie unzureichend radikale Operationstechnik, ausgedehnte Tumoren, erschwerte intraoperative Verh\u00e4ltnisse aufgrund der Tumorlokalisation oder bei der Rezidiv-Chirurgie. Zudem neigen junge Patienten und Raucher vermehrt zu Rezidiven. Risikofaktoren f\u00fcr eine maligne Entartung sind gro\u00dfe Tumoren, Rauchen, h\u00f6heres Alter bei Erstdiagnose, weibliches Geschlecht, Knocheninvasion und fehlende inflammatorische Polypen. Histopathologische Risikofaktoren f\u00fcr Rezidive sowie f\u00fcr maligne Entartung sind Dysplasien, Hyperkeratose, plattenepitheliale Hyperplasie und \u2013 sofern bestimmt \u2013 eine erh\u00f6hte Proliferationsrate, Aneuploidie sowie eine Infektion mit humanen Papillomaviren.<\/jats:p><jats:p>Schlussfolgerungen\u2002Eine vollst\u00e4ndige Resektion der sinunasalen Papillome unter tumorchirurgischen Kautelen ist der Goldstandard. Postoperativ ist eine engmaschige Tumornachsorge (analog zu malignen Tumoren) zwingend erforderlich. Die meisten Autoren empfehlen einen Nachsorgezeitraum von mindestens 5 Jahren, manche sogar eine lebenslange Nachsorge. Patienten mit einem oder mehreren Risikofaktoren sollten engmaschiger nachbetreut werden.<\/jats:p>","DOI":"10.1055\/a-1211-2889","type":"journal-article","created":{"date-parts":[[2021,3,30]],"date-time":"2021-03-30T22:51:48Z","timestamp":1617144708000},"page":"261-269","source":"Crossref","is-referenced-by-count":0,"title":["Tumornachsorge sinunasaler Papillome \u2013 Risikofaktoren f\u00fcr Rezidiv-Entwicklung und maligne Entartung"],"prefix":"10.1055","volume":"100","author":[{"given":"Anja","family":"P\u00e4hler","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Hals-Nasen-Ohrenheilkunde, KRH-Klinikum Nordstadt, Hannover, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans-J\u00fcrgen","family":"Welkoborsky","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Hals-Nasen-Ohrenheilkunde, KRH-Klinikum Nordstadt, Hannover, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2021,3,30]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1038\/modpathol.3880524","article-title":"Schneiderian papillomas and nonsalivary glandular neoplasms of the head and neck","volume":"15","author":"L Barnes","year":"2002","journal-title":"Mod Pathol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"9195163","DOI":"10.1155\/2017\/9195163","article-title":"Risk factors of recurrence and malignant transformation of sinonasal inverted papilloma","volume":"2017","author":"M Gamrot-Wrzol","year":"2017","journal-title":"Biomed Res Int"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.wjorl.2016.11.004","article-title":"Etiology of sinonasal inverted papilloma: A narrative review","volume":"3","author":"M J Wang","year":"2017","journal-title":"World J Otorhinolaryngol Head Neck Surg"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1136\/jcp.56.3.174","article-title":"HPV infections in benign and malignant sinonasal lesions","volume":"56","author":"K J Syrjanen","year":"2003","journal-title":"J\u00a0Clin Pathol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1007\/s12105-008-0048-3","article-title":"The role of the human papillomavirus in the pathogenesis of Schneiderian inverted papillomas: an analytic overview of the evidence","volume":"2","author":"W Lawson","year":"2008","journal-title":"Head Neck Pathol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"2457","DOI":"10.4103\/0366-6999.164929","article-title":"Survival outcome of squamous cell carcinoma arising from sinonasal inverted papilloma","volume":"128","author":"Q Z Liang","year":"2015","journal-title":"Chin Med J"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"2637","DOI":"10.3892\/ol.2014.2539","article-title":"Malignant transformation of sinonasal inverted papilloma: A retrospective analysis of 32 cases","volume":"8","author":"H X Yu","year":"2014","journal-title":"Oncol Lett"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1002\/1097-0142(197209)30:3<668::AID-CNCR2820300315>3.0.CO;2-B","article-title":"Papillomatosis of nasal cavity and paranasal sinuses (inverted papilloma, squamous papilloma). 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