{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,12,19]],"date-time":"2023-12-19T16:33:01Z","timestamp":1703003581646},"reference-count":29,"publisher":"Georg Thieme Verlag KG","issue":"10","funder":[{"name":"University Grants Commission, New Delhi","award":["F. 4\u20131\/2006 (BSR)"],"award-info":[{"award-number":["F. 4\u20131\/2006 (BSR)"]}]},{"name":"University Grants Commission, New Delhi","award":["11\u201326\/2008(BSR"],"award-info":[{"award-number":["11\u201326\/2008(BSR"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Drug Res (Stuttg)"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Knowledge of the aetiological agents and its susceptibility to antimicrobial\n                        agents enables the clinician to initiate appropriate empirical antimicrobial\n                        therapy and guides diagnostic procedures. The aims of the study were to\n                        identify prevalence of bacterial pathogens causing sepsis and observe their\n                        antimicrobial resistance trends in hospitalized patients. A prospective\n                        cohort study was conducted on patients of sepsis admitted at a university\n                        hospital over a period of six months. Pathogens were identified by\n                        morphological, biochemical and serological tests as per the American Society\n                        for Microbiology. Antibacterial sensitivity of bacterial strains isolated\n                        from clinically diagnosed sepsis was carried out by Kirby-Bauer disk\n                        diffusion method and interpreted according Clinical and Laboratory Standards\n                        Institute guidelines. The data were analyzed by using Statistical Package\n                        for Social Sciences, version 16.0 (SPSS 16.0, Chicago, IL, USA). Coagulase\n                        negative Staphylococcus (63.5%) and Staphylococcus\n                            aureus (23.1%) were the most frequently isolated Gram\n                        positive bacteria. Acinetobacter species (31%) and\n                            Salmonella typhi (24.1%) were the most frequently\n                        isolated Gram negative bacteria. Coagulase negative Staphylococcus\n                        showed significant resistance to ciprofloxacin and tetracycline.\n                            Acinetobacter species showed significant resistance to\n                        ampicillin, amoxicillin and amoxiclav. Salmonella typhi showed\n                        significant resistance to ampicillin, amoxicillin, cefotaxime, netilmicin\n                        and, tetracycline. Escherichia coli showed significant resistance to\n                        ampicillin and netilmicin. All the stains of Staphylococcus aureus\n                        were resistant to amoxicillin. Coagulase negative Staphylococcus and\n                            Acinetobacter species were predominant Gram positive and Gram\n                        negative bacteria, respectively, causing sepsis. Increasing rates of\n                        bacterial resistance to commonly use antimicrobial agents were observed.<\/jats:p>","DOI":"10.1055\/a-1213-2206","type":"journal-article","created":{"date-parts":[[2020,8,13]],"date-time":"2020-08-13T22:50:27Z","timestamp":1597359027000},"page":"463-471","source":"Crossref","is-referenced-by-count":2,"title":["Trends of Antimicrobial Resistance of Sepsis Pathogens at a\n                    University Hospital in New Delhi, India"],"prefix":"10.1055","volume":"70","author":[{"given":"Md Shamshir","family":"Alam","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Faculty of Pharmacy, Jamia Hamdard, New\n                    Delhi, India"},{"name":"Department of Pharmacy Practice, MM College of Pharmacy, Maharishi\n                    Markandeshwar (Deemed to be University), Mullana, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Prem","family":"Kapur","sequence":"additional","affiliation":[{"name":"Department of Medicine, Hamdard Institute of Medical Sciences &\n                    Research and Hakeem Abdul Hameed Centenary Hospital, Hamdard University, New\n                    Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ParuKutty","family":"Pillai","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Majeedia Hospital, Jamia Hamdard, New\n                    Delhi, India"},{"name":"Department of Microbiology, LHMC, New Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Krishna Kolappa","family":"Pillai","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Faculty of Pharmacy, Jamia Hamdard, New\n                    Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2020,8,13]]},"reference":[{"key":"ref1","first-page":"987","volume-title":"Sepsis, severe sepsis, and septic shock","author":"R S Munford","year":"2010"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1164\/rccm.201504-0781OC","article-title":"Assessment of global incidence and mortality of hospital treated sepsis-current\n                    estimates and limitations","volume":"193","author":"C Fleischmann","year":"2016","journal-title":"Am J Respir Crit Care Med"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1093\/jac\/dkn284","article-title":"A prospective double-blind randomized trial comparing intraluminal ethanol with\n                    heparinized saline for the prevention of catheter associated Blood-stream\n                    infection in immunosuppressed haematology patients","volume":"62","author":"J 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Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-1213-2206.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,28]],"date-time":"2020-09-28T22:38:00Z","timestamp":1601332680000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-1213-2206"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8,13]]},"references-count":29,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2020,9,28]]},"published-print":{"date-parts":[[2020,10]]}},"URL":"https:\/\/doi.org\/10.1055\/a-1213-2206","relation":{},"ISSN":["2194-9379","2194-9387"],"issn-type":[{"value":"2194-9379","type":"print"},{"value":"2194-9387","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,8,13]]}}}