{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T02:36:38Z","timestamp":1792290998028,"version":"4.4.0"},"reference-count":26,"publisher":"Georg Thieme Verlag KG","issue":"10","license":[{"start":{"date-parts":[[2020,9,22]],"date-time":"2020-09-22T00:00:00Z","timestamp":1600732800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Endosc Int Open"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Background and study aims\u2002The Full-Thickness Resection Device (FTRD) provides a novel treatment option for lesions not amenable to conventional endoscopic resection techniques. There are limited data on the efficacy and safety of FTRD for resection of upper gastrointestinal tract (GIT) lesions.<\/jats:p>\n                  <jats:p>Patients and methods\u2002This was an international multicenter retrospective study, including patients who had an endoscopic resection of an upper GIT lesion using the FTRD between January 2017 and February 2019.<\/jats:p>\n                  <jats:p>Results\u2002Fifty-six patients from 13 centers were included. The most common lesions were mesenchymal neoplasms (n\u200a=\u200a23, 41\u200a%), adenomas (n\u200a=\u200a7, 13\u200a%), and hamartomas (n\u200a=\u200a6, 11\u200a%). Eighty-four percent of lesions were located in the stomach, and 14\u200a% in the duodenum. The average size of lesions was 14\u200amm (range 3 to 33\u200amm). Deployment of the FTRD was technically successful in 93\u200a% of patients (n\u200a=\u200a52) leading to complete and partial resection in 43 (77\u200a%) and 9 (16\u200a%) patients, respectively. Overall, the FTRD led to negative histological margins (R0 resection) in 38 (68\u200a%) of patients. A total of 12 (21\u200a%) mild or moderate adverse events (AEs) were reported. Follow-up endoscopy was performed in 31 patients (55\u200a%), on average 88 days after the procedure (IQR 68\u2013138 days). Of these, 30 patients (97\u200a%) did not have any residual or recurrent lesion on endoscopic examination and biopsy, with residual adenoma in one patient (3\u200a%).<\/jats:p>\n                  <jats:p>Conclusions\u2002Our results suggest a high technical success rate and an acceptable histologically complete resection rate, with a low risk of AEs and early recurrence for FTRD resection of upper GIT lesions.<\/jats:p>","DOI":"10.1055\/a-1216-1439","type":"journal-article","created":{"date-parts":[[2020,9,22]],"date-time":"2020-09-22T19:25:41Z","timestamp":1600802741000},"page":"E1291-E1301","source":"Crossref","is-referenced-by-count":48,"title":["Full-thickness resection device (FTRD) for treatment of upper gastrointestinal tract lesions: the first international experience"],"prefix":"10.1055","volume":"08","author":[{"given":"Mouen A.","family":"Khashab","sequence":"first","affiliation":[{"name":"Division of Gastroenterology, Johns Hopkins Hospital, Baltimore, Maryland, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reem Z.","family":"Sharaiha","sequence":"first","affiliation":[{"name":"Weill Cornell Medicine, Division of Gastroenterology and Hepatology, Department of Medicine, New York, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaveh","family":"Hajifathalian","sequence":"additional","affiliation":[{"name":"Weill Cornell Medicine, Division of Gastroenterology and Hepatology, Department of Medicine, New York, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yervant","family":"Ichkhanian","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Johns Hopkins Hospital, Baltimore, Maryland, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qais","family":"Dawod","sequence":"additional","affiliation":[{"name":"Weill Cornell Medicine, Division of Gastroenterology and Hepatology, Department of Medicine, New York, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Meining","sequence":"additional","affiliation":[{"name":"Interventional and Experimental Endoscopy, Department of Internal Medicine I, Ulm University, Ulm, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arthur","family":"Schmidt","sequence":"additional","affiliation":[{"name":"Department of Medicine II, Medical Center, University of Freiburg, Faculty of Medicine, Freiburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas","family":"Glaser","sequence":"additional","affiliation":[{"name":"Department of Medicine II, Medical Center, University of Freiburg, Faculty of Medicine, Freiburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kia","family":"Vosoughi","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Johns Hopkins Hospital, Baltimore, Maryland, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David L.","family":"Diehl","sequence":"additional","affiliation":[{"name":"Interventional and Experimental Endoscopy, Department of Internal Medicine I, Ulm University, Ulm, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian S.","family":"Grimm","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Nutrition, Geisinger Medical Center, Danville, Pennsylvania, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theodore","family":"James","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, University of North Carolina, Chapel Hill, North Carolina, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam W.","family":"Templeton","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, University of Washington, Seattle, Washington, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason B.","family":"Samarasena","sequence":"additional","affiliation":[{"name":"H. 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Lim","year":"2016","journal-title":"Medicine"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1097\/MCG.0b013e3182936c87","article-title":"A multidisciplinary approach to the diagnosis and treatment of gastrointestinal stromal tumor","volume":"47","author":"D K Mullady","year":"2013","journal-title":"J Clin Gastroenterol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1097\/MEG.0b013e328356eae2","article-title":"Endosonographic large-bore biopsy of gastric subepithelial tumors: a prospective multicenter study","volume":"24","author":"A J Eckardt","year":"2012","journal-title":"Europ J Gastroenterol Hepatol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1155\/2006\/434761","article-title":"Gastrointestinal stromal tumours: consensus statement on diagnosis and treatment","volume":"20","author":"M E Blackstein","year":"2006","journal-title":"Can J 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