{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T08:33:26Z","timestamp":1740126806815,"version":"3.37.3"},"reference-count":15,"publisher":"Georg Thieme Verlag KG","issue":"11","license":[{"start":{"date-parts":[[2020,8,6]],"date-time":"2020-08-06T00:00:00Z","timestamp":1596672000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"German Center for Diabetes Research"},{"DOI":"10.13039\/501100013295","name":"Helmholtz Zentrum M\u00fcnchen","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100013295","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Klinikum der Universit\u00e4t M\u00fcnchen"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Horm Metab Res"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Animal data link high circulating fetuin-A to low insulin sensitivity and\nobservational studies identify the hepatokine as a marker of future incident\ntype 2 diabetes mellitus in humans. However, a recent, well-powered Mendelian\nrandomization study finds no causal role. We therefore tested in a\ndeeply-phenotyped human cohort if circulating fetuin-A correlates independently\nwith insulin sensitivity and how it relates to the metabolic syndrome and\nectopic fat deposition. We analyzed data from 290 young women with and without\nrecent gestational diabetes mellitus. We found that circulating fetuin-A\ncorrelates inversely with insulin sensitivity in univariate analyses, but that\nthis correlation is lost after adjustment for markers of the metabolic syndrome\nand of fatty liver. Additionally, we investigated which fat compartment\nassociates most strongly with circulating fetuin-A. In whole body MRI data from\na subcohort of 152 women, this was liver fat content. We conclude that high\ncirculating fetuin-A occurs as part of the metabolic syndrome in young women and\nassociates most strongly with liver fat content. Its close link to the metabolic\nsyndrome may also cause the inverse correlation of circulating fetuin-A with\ninsulin sensitivity as we found no independent association.<\/jats:p>","DOI":"10.1055\/a-1216-4405","type":"journal-article","created":{"date-parts":[[2020,8,7]],"date-time":"2020-08-07T02:54:06Z","timestamp":1596768846000},"page":"809-814","source":"Crossref","is-referenced-by-count":0,"title":["No Independent Association of Circulating Fetuin-A with Insulin\nSensitivity in Young Women"],"prefix":"10.1055","volume":"52","author":[{"given":"Sabrina","family":"Reif","sequence":"additional","affiliation":[{"name":"Diabetes Research Group, Medizinische Klinik und Poliklinik IV,\nKlinikum der Universit\u00e4t M\u00fcnchen, M\u00fcnchen,\nGermany"},{"name":"Clinical Cooperation Group Type 2 Diabetes, Helmholtz Zentrum\nM\u00fcnchen, Neuherberg, Germany"},{"name":"German Center for Diabetes Research (DZD), Neuherberg,\nGermany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah","family":"Moschko","sequence":"additional","affiliation":[{"name":"Diabetes Research Group, Medizinische Klinik und Poliklinik IV,\nKlinikum der Universit\u00e4t M\u00fcnchen, M\u00fcnchen,\nGermany"},{"name":"Clinical Cooperation Group Type 2 Diabetes, Helmholtz Zentrum\nM\u00fcnchen, Neuherberg, Germany"},{"name":"German Center for Diabetes Research (DZD), Neuherberg,\nGermany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christina","family":"Gar","sequence":"additional","affiliation":[{"name":"Diabetes Research Group, Medizinische Klinik und Poliklinik IV,\nKlinikum der Universit\u00e4t M\u00fcnchen, M\u00fcnchen,\nGermany"},{"name":"Clinical Cooperation Group Type 2 Diabetes, Helmholtz Zentrum\nM\u00fcnchen, Neuherberg, Germany"},{"name":"German Center for Diabetes Research (DZD), Neuherberg,\nGermany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Uta","family":"Ferrari","sequence":"additional","affiliation":[{"name":"Diabetes Research Group, Medizinische Klinik und Poliklinik IV,\nKlinikum der Universit\u00e4t M\u00fcnchen, M\u00fcnchen,\nGermany"},{"name":"Clinical Cooperation Group Type 2 Diabetes, Helmholtz Zentrum\nM\u00fcnchen, Neuherberg, Germany"},{"name":"German Center for Diabetes Research (DZD), Neuherberg,\nGermany"},{"name":"Department of Geriatrics, Medizinische Klinik und Poliklinik IV,\nKlinikum der Universit\u00e4t M\u00fcnchen, M\u00fcnchen,\nGermany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nina","family":"Hesse","sequence":"additional","affiliation":[{"name":"Klinik und Poliklinik f\u00fcr Radiologie, Klinikum der\nUniversit\u00e4t M\u00fcnchen, M\u00fcnchen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nora N.","family":"Sommer","sequence":"additional","affiliation":[{"name":"Klinik und Poliklinik f\u00fcr Radiologie, Klinikum der\nUniversit\u00e4t M\u00fcnchen, M\u00fcnchen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jochen","family":"Sei\u00dfler","sequence":"additional","affiliation":[{"name":"Diabetes Research Group, Medizinische Klinik und Poliklinik IV,\nKlinikum der Universit\u00e4t M\u00fcnchen, M\u00fcnchen,\nGermany"},{"name":"Clinical Cooperation Group Type 2 Diabetes, Helmholtz Zentrum\nM\u00fcnchen, Neuherberg, Germany"},{"name":"German Center for Diabetes Research (DZD), Neuherberg,\nGermany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Lechner","sequence":"additional","affiliation":[{"name":"Diabetes Research Group, Medizinische Klinik und Poliklinik IV,\nKlinikum der Universit\u00e4t M\u00fcnchen, M\u00fcnchen,\nGermany"},{"name":"Clinical Cooperation Group Type 2 Diabetes, Helmholtz Zentrum\nM\u00fcnchen, Neuherberg, Germany"},{"name":"German Center for Diabetes Research (DZD), Neuherberg,\nGermany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2020,8,6]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.1093\/ndt\/gfw048","article-title":"Fetuin-A-containing calciprotein particles in mineral trafficking and vascular\ndisease","volume":"31","author":"S G Holt","year":"2016","journal-title":"Nephrol Dial Transplant"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"e1765","DOI":"10.1371\/journal.pone.0001765","article-title":"Fetuin-A induces cytokine expression and suppresses adiponectin production","volume":"3","author":"A M Hennige","year":"2008","journal-title":"PloS one"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1038\/nm.2851","article-title":"Fetuin-A acts as an endogenous ligand of TLR4 to promote lipid-induced insulin\nresistance","volume":"18","author":"D Pal","year":"2012","journal-title":"Nat Med"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1016\/S0898-6568(96)00110-6","article-title":"Recombinant human alpha 2-HS glycoprotein inhibits insulin-stimulated mitogenic\npathway without affecting metabolic signalling in Chinese hamster ovary cells\noverexpressing the human insulin receptor","volume":"8","author":"P R Srinivas","year":"1996","journal-title":"Cell Signal"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1038\/nm.3116","article-title":"Circulating fetuin-A and free fatty acids interact to predict insulin resistance\nin humans","volume":"19","author":"N Stefan","year":"2013","journal-title":"Nat Med"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"853","DOI":"10.2337\/diacare.29.04.06.dc05-1938","article-title":"Alpha2-Heremans-Schmid glycoprotein\/fetuin-A is associated with insulin\nresistance and fat accumulation in the liver in humans","volume":"29","author":"N Stefan","year":"2006","journal-title":"Diabetes Care"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.regpep.2012.02.004","article-title":"Relationship of fetuin-A levels to weight-dependent insulin resistance and type\n2 diabetes mellitus","volume":"178","author":"J Erdmann","year":"2012","journal-title":"Regul Peptides"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"925","DOI":"10.5551\/jat.3830","article-title":"Serum fetuin-A is an independent marker of insulin resistance in Japanese\nmen","volume":"17","author":"A Ishibashi","year":"2010","journal-title":"J Atheroscler Thromb"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"468","DOI":"10.2337\/diacare.29.02.06.dc05-1484","article-title":"Association of serum fetuin-A with insulin resistance in type 2 diabetic and\nnondiabetic subjects","volume":"29","author":"K Mori","year":"2006","journal-title":"Diabetes Care"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"4717","DOI":"10.1210\/jc.2012-2414","article-title":"Increased fetuin-A concentrations in impaired glucose tolerance with or without\nnonalcoholic fatty liver disease, but not impaired fasting glucose","volume":"97","author":"H Y Ou","year":"2012","journal-title":"J Clin Endocrinol Metab"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"E910","DOI":"10.1210\/jc.2014-3898","article-title":"The diabetes risk phenotype of young women with recent gestational diabetes","volume":"100","author":"M Rottenkolber","year":"2015","journal-title":"J Clin Endocrinol Metab"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1530\/EJE-17-1053","article-title":"Association of fetuin-A with incident type 2 diabetes: results from the\nMONICA\/KORA Augsburg study and a systematic meta-Analysis","volume":"178","author":"C Sujana","year":"2018","journal-title":"Eur J Endocrinol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"e92238","DOI":"10.1371\/journal.pone.0092238","article-title":"Impact of the adipokine adiponectin and the hepatokine fetuin-A on the\ndevelopment of type 2 diabetes: Prospective cohort- and cross-sectional\nphenotyping studies","volume":"9","author":"N Stefan","year":"2014","journal-title":"PLoS One"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.2337\/db17-1268","article-title":"Circulating fetuin-A and risk of type 2 diabetes: A mendelian randomization\nanalysis","volume":"67","author":"J Kroger","year":"2018","journal-title":"Diabetes"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1462","DOI":"10.2337\/diacare.22.9.1462","article-title":"Insulin sensitivity indices obtained from oral glucose tolerance testing:\nComparison with the euglycemic insulin clamp","volume":"22","author":"M Matsuda","year":"1999","journal-title":"Diabetes Care"}],"container-title":["Hormone and Metabolic Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-1216-4405.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,12,18]],"date-time":"2020-12-18T02:17:50Z","timestamp":1608257870000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-1216-4405"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8,6]]},"references-count":15,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2020,11,2]]},"published-print":{"date-parts":[[2020,11]]}},"URL":"https:\/\/doi.org\/10.1055\/a-1216-4405","relation":{},"ISSN":["0018-5043","1439-4286"],"issn-type":[{"type":"print","value":"0018-5043"},{"type":"electronic","value":"1439-4286"}],"subject":[],"published":{"date-parts":[[2020,8,6]]}}}