{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T21:14:55Z","timestamp":1772140495672,"version":"3.50.1"},"reference-count":28,"publisher":"Georg Thieme Verlag KG","issue":"06","license":[{"start":{"date-parts":[[2020,7,10]],"date-time":"2020-07-10T00:00:00Z","timestamp":1594339200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Endoscopy"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:p>\n            Background Although endoscopic ultrasound (EUS) features and criteria have been described in chronic pancreatitis, challenges remain with interoperator variability and ease of adoption. The aim of this study was to define and validate the EUS features of chronic pancreatitis in a multicenter prospective study in Asia.<\/jats:p><jats:p>\n            Method\u2002The study was divided into two parts: the first part was conducted to derive the EUS features of chronic pancreatitis with adequate interoperator agreement; the second was to prospectively evaluate these features in a multicenter cross-sectional study and determine the optimal combination of features for the diagnosis of chronic pancreatitis. Prospectively enrolled cases had standard internationally validated radiologic or histologic features of chronic pancreatitis, and controls were patients without chronic pancreatitis who underwent EUS examination.<\/jats:p><jats:p>\n            Results\u2002The top six EUS features that had good interobserver agreement (mean kappa 0.73, range 0.60\u200a\u2013\u200a0.90) were selected to be further evaluated in part II of the study. These included: hyperechoic foci with shadowing, lobularity with honeycombing, cysts, dilated main pancreatic duct, dilated side branches, and calculi in the main pancreatic duct. A total of 284 subjects (132 cases, 152 controls) were enrolled from 12 centers in Asia. All six features had high accuracy ranging from 63.3\u200a% to 89.1\u200a%. Two or more of these six EUS features accurately defined chronic pancreatitis (sensitivity 94.7\u200a%, specificity 98.0\u200a%), with an area under the receiver operating curve of 0.986.<\/jats:p><jats:p>\n            Conclusion\u2002This multicenter Asian study characterized and defined the EUS features of chronic pancreatitis. This provides a useful tool in clinical practice and further research in pancreatic cancer surveillance.<\/jats:p>","DOI":"10.1055\/a-1217-3112","type":"journal-article","created":{"date-parts":[[2020,7,10]],"date-time":"2020-07-10T23:03:00Z","timestamp":1594422180000},"page":"595-602","source":"Crossref","is-referenced-by-count":9,"title":["Defining the endoscopic ultrasound features of chronic pancreatitis in Asians: a multicenter validation study"],"prefix":"10.1055","volume":"53","author":[{"given":"Calvin Jianyi","family":"Koh","sequence":"additional","affiliation":[{"name":"Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore"},{"name":"Division of Gastroenterology and Hepatology, National University Hospital, Singapore, Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sundeep","family":"Lakhtakia","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Asian Institute of Gastroenterology, Hyderabad, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mitsuhiro","family":"Kida","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Kitasato University Hospital, Sagamihara, Kanagawa, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cosmas Rinaldi A.","family":"Lesmana","sequence":"additional","affiliation":[{"name":"Digestive Disease & GI Oncology Center, Medistra Hospital, Jakarta, Indonesia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tiing Leong","family":"Ang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Changi General Hospital, Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles Kieng Fong","family":"Vu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Tan Tock Seng Hospital, Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Than Than","family":"Aye","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Sanpya General Hospital, Thingan Gyun, Myanmar"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sun Hwa","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Majid A.","family":"Almadi","sequence":"additional","affiliation":[{"name":"Department of Medicine, King Khalid University Hospital, Riyadh, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charing Ching-Ning","family":"Chong","sequence":"additional","affiliation":[{"name":"Department of Surgery, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong 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India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nonthalee","family":"Pausawasdi","sequence":"additional","affiliation":[{"name":"Mahidol University Faculty of Medicine, Siriraj Hospital, Bangkok, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jahangeer","family":"Basha","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Asian Institute of Gastroenterology, Hyderabad, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhen-Dong","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, The Second Military Medical University, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ai Ming","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anthony Yuen Bun","family":"Teoh","sequence":"additional","affiliation":[{"name":"Department of Surgery, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong-Wan","family":"Seo","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hsiu-Po","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Khek Yu","family":"Ho","sequence":"additional","affiliation":[{"name":"Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore"},{"name":"Division of 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Gastroenterology"}],"container-title":["Endoscopy"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-1217-3112.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,10]],"date-time":"2022-08-10T09:44:55Z","timestamp":1660124695000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-1217-3112"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7,10]]},"references-count":28,"journal-issue":{"issue":"06","published-online":{"date-parts":[[2021,5,26]]},"published-print":{"date-parts":[[2021,6]]}},"URL":"https:\/\/doi.org\/10.1055\/a-1217-3112","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0013-726X","1438-8812"],"issn-type":[{"value":"0013-726X","type":"print"},{"value":"1438-8812","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2020,7,10]]},"published":{"date-parts":[[2020,7,10]]}}}