{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,3]],"date-time":"2025-07-03T11:25:29Z","timestamp":1751541929907},"reference-count":26,"publisher":"Georg Thieme Verlag KG","issue":"09","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Drug Res (Stuttg)"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Pain models are mostly in rodents and between them formalin orofacial test allow discrimination among antinociception and anti-inflammation. This assay use a formalin solution injected into the upper right lip of each mouse which produces two periods of pain separated by an inactive period. The aims of the present study were to evaluate, by means of the isobolographic analysis, the antinociception and anti-inflammatory activities of the following NSAIDs: dexketoprofen, diclofenac, piroxicam and metamizole in an orofacial. The NSAIDs administered intraperitoneally produced a dose-dependent activity with the following order of potency of the rubbing behavior, in phase I: diclofenac&gt;dexketoprofen&gt;piroxicam&gt;metamizole and in the phase II: metamizole&gt;diclofenac&gt;piroxicam&gt;dexketoprofen. The coadministration of NSAIDs resulted in a synergistic interaction, which according to the value of the potency of the combination (II) presents the following range: dexketoprofen plus metamizole&gt;dexketoprofen plus diclofenac&gt;dexketoprofen plus piroxicam, in phase I and dexketoprofen plus metamizole&gt;dexketoprofen plus piroxicam&gt;dexketoprofen plus diclofenac, on the phase II. Data obtained in this work corroborate that NSAIDs alone or in combination inducing activities by additional mechanism of action supplementary to inhibition of COXs. This fact represent a novel approach that could be used as multimodal management of orofacial pain, since with this treatment strategies, by the reduction of doses, can help to diminish side effects of other dugs such opioids.<\/jats:p>","DOI":"10.1055\/a-1217-6777","type":"journal-article","created":{"date-parts":[[2020,7,24]],"date-time":"2020-07-24T23:01:08Z","timestamp":1595631668000},"page":"424-428","source":"Crossref","is-referenced-by-count":1,"title":["The Antinociceptive Activities of Certain NSAIDS Combinations in Murine Orofacial Test"],"prefix":"10.1055","volume":"70","author":[{"given":"Hugo F.","family":"Miranda","sequence":"additional","affiliation":[{"name":"Neuroscience Department, Faculty of Medicine, Universidad de Chile, Santiago, Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Viviana","family":"Noriega","sequence":"additional","affiliation":[{"name":"Cardiovascular Department, Clinical Hospital, Universidad de Chile, Santiago, Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernando","family":"Sierralta","sequence":"additional","affiliation":[{"name":"Pharmacology Program, ICBM, Faculty of Medicine, Universidad de Chile, Santiago, Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ram\u00f3n","family":"Sotomayor-Z\u00e1rate","sequence":"additional","affiliation":[{"name":"Neurochemistry and Neuropharmacology Laboratory, Institute of Physiology, Faculty of Sciences, Universidad de Valpara\u00edso, Valpara\u00edso, Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan Carlos","family":"Prieto","sequence":"additional","affiliation":[{"name":"Cardiovascular Department, Clinical Hospital, Universidad de Chile, Santiago, Chile"},{"name":"Pharmacology Program, ICBM, Faculty of Medicine, Universidad de Chile, Santiago, Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2020,7,24]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1016\/j.jpain.2006.04.010","article-title":"The orofacial formalin Formalin test in the mouse: A behavioral model for studying physiology and modulation Of trigeminal nociception","volume":"7","author":"P Luccarini","year":"2006","journal-title":"J Pain"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1038\/nrn2606","article-title":"Animal models of pain: progress and challenges","volume":"10","author":"J S Mogil","year":"2009","journal-title":"Nat Rev Neurosci"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/j.bbalip.2014.09.016","article-title":"Cyclooxygenase inhibitors: From parmacology to clinical read-outs","volume":"1851","author":"P Patrignani","year":"2015","journal-title":"Biochimica et Biophysica 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