{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T21:56:03Z","timestamp":1788386163080,"version":"build-2803163510"},"reference-count":25,"publisher":"Georg Thieme Verlag KG","issue":"10","license":[{"start":{"date-parts":[[2020,9,22]],"date-time":"2020-09-22T00:00:00Z","timestamp":1600732800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Endosc Int Open"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Backround and study aims\u2002Duodenal cancer is the cancer most often seen in patients with familial adenomatous polyposis (FAP) who have undergone risk-reducing colonic surgery. Almost all patients with FAP eventually develop duodenal adenomas and risk for duodenal cancer is up to 12\u200a% with poor prognosis. In addition, there is a rising concern regarding increased gastric cancer risk in patients with FAP. Our aim was to enhance polyp detection by using CE (CE) with the application of indigo carmine dye.<\/jats:p><jats:p>\n          Patient and methods\u2002We conducted a prospective, blinded study of patients with FAP undergoing endoscopic examination of the upper gastrointestinal tract. First, a standard white-light examination (WLE) was done followed by an examination performed by an endoscopist who was blinded to the previous examination, using chromoendoscopy (CE) (0.4\u200a% indigo carmine dye).<\/jats:p><jats:p>\n          Results\u2002Fifty patients were included in the study. Using WLE, a median number of 13 adenomas (range 0\u201390) was detected compared to 23 adenomas\/patient (range 0\u2013150; P\u200a&lt;\u200a0.0001) detected after staining, leading to a higher Spigelman stage in 16 patients (32\u200a%; P\u200a=\u200a0.0003). CE detected significantly more larger adenomas (&gt;\u200a10\u200amm) than WLE (12 vs. 19; P\u200a=\u200a0.0391). In the gastric antral region, a median number of 0 adenomas (range 0\u20136) before and 0.5 adenomas (range 0\u20137) after staining (P\u200a=\u200a0.0025) were detected.<\/jats:p><jats:p>\n          Conclusion\u2002This prospective endoscopic trial, to our knowledge the largest in patients with FAP, showed a significant impact of CE on adenoma detection and therapeutic management in the upper gastrointestinal tract. This leads to more intensive surveillance intervals.<\/jats:p>","DOI":"10.1055\/a-1220-6699","type":"journal-article","created":{"date-parts":[[2020,9,22]],"date-time":"2020-09-22T23:25:41Z","timestamp":1600817141000},"page":"E1308-E1314","source":"Crossref","is-referenced-by-count":10,"title":["Dye chromoendoscopy leads to a higher adenoma detection in the duodenum and stomach in patients with familial adenomatous polyposis"],"prefix":"10.1055","volume":"08","author":[{"given":"C. P.","family":"Strassburg","sequence":"first","affiliation":[{"name":"Department of Internal Medicine I, University Hospital Bonn, Germany"},{"name":"National Center for Hereditary Tumor Syndromes, University Hospital Bonn, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Nattermann","sequence":"first","affiliation":[{"name":"Department of Internal Medicine I, University Hospital Bonn, Germany"},{"name":"National Center for Hereditary Tumor Syndromes, University Hospital Bonn, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"H\u00fcneburg","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I, University Hospital Bonn, Germany"},{"name":"National Center for Hereditary Tumor Syndromes, University Hospital Bonn, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Heling","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I, University Hospital Bonn, Germany"},{"name":"National Center for Hereditary Tumor Syndromes, University Hospital Bonn, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. J.","family":"Kaczmarek","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I, University Hospital Bonn, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"van Heteren","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I, University Hospital Bonn, Germany"},{"name":"National Center for Hereditary Tumor Syndromes, University Hospital Bonn, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Olthaus","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I, University Hospital Bonn, Germany"},{"name":"National Center for Hereditary Tumor Syndromes, University Hospital Bonn, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Fimmers","sequence":"additional","affiliation":[{"name":"Institute for Medical Biometry, Informatics and Epidemiology (IMBIE), University Hospital Bonn, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Berger","sequence":"additional","affiliation":[{"name":"Institute for Medical Biometry, Informatics and Epidemiology (IMBIE), University Hospital Bonn, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Coch","sequence":"additional","affiliation":[{"name":"Clinical study core unit (SZB), University Hospital Bonn, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. F.","family":"Lau","sequence":"additional","affiliation":[{"name":"National Center for Hereditary Tumor Syndromes, University Hospital Bonn, Germany"},{"name":"Institute of Pathology, University Hospital Bonn, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Kristiansen","sequence":"additional","affiliation":[{"name":"National Center for Hereditary Tumor Syndromes, University Hospital Bonn, Germany"},{"name":"Institute of Pathology, University Hospital Bonn, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T. J.","family":"Weism\u00fcller","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I, University Hospital Bonn, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Spier","sequence":"additional","affiliation":[{"name":"National Center for Hereditary Tumor Syndromes, University Hospital Bonn, Germany"},{"name":"Institute of Human Genetics, University Hospital Bonn, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Aretz","sequence":"additional","affiliation":[{"name":"National Center for Hereditary Tumor Syndromes, University Hospital Bonn, Germany"},{"name":"Institute of Human Genetics, University Hospital Bonn, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2020,9,22]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1038\/sj.ejhg.5201088","article-title":"Frequency and parental origin 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