{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,4,28]],"date-time":"2023-04-28T08:54:25Z","timestamp":1682672065706},"reference-count":15,"publisher":"Georg Thieme Verlag KG","issue":"09","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Horm Metab Res"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:p>Dear Editors,<\/jats:p><jats:p>Hypocalcemia is not unusual in patients hospitalized for critical illness and has\n                    also been described after general surgery in addition to head and neck surgical\n                    procedures 1\n          2\n          3. Hypocalcemic events commonly\n                    occur in the setting of massive blood transfusion, albumin deficiency, vitamin D\n                    deficiency, and\/or hypomagnesemia. In the absence of these factors, only\n                    slight decreases in calcium levels within the normal range have been reported during\n                    surgical procedures 1. Cytoreductive surgery\n                    with hyperthermic intraperitoneal chemotherapy (HIPEC) causing asymptomatic\n                    hypocalcemia has only been reported in two previous studies 4\n          5.\n                    The etiology is unclear. We here report a patient who developed severe symptomatic\n                    hypocalcemia likely as a result of a profound inflammatory reaction with transient\n                    hypoparathyroidism after HIPEC.<\/jats:p>","DOI":"10.1055\/a-1220-6971","type":"journal-article","created":{"date-parts":[[2020,8,8]],"date-time":"2020-08-08T01:19:20Z","timestamp":1596849560000},"page":"689-690","source":"Crossref","is-referenced-by-count":2,"title":["Severe Hypocalcemia and Transient Hypoparathyroidism After\n                    Hyperthermic Intraperitoneal Chemotherapy"],"prefix":"10.1055","volume":"52","author":[{"given":"Senthuran","family":"Tharmalingam","sequence":"additional","affiliation":[{"name":"Fox Chase Cancer Center, Philadelphia, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanjay","family":"Reddy","sequence":"additional","affiliation":[{"name":"Fox Chase Cancer Center, Philadelphia, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pankaj","family":"Sharda","sequence":"additional","affiliation":[{"name":"Fox Chase Cancer Center, Philadelphia, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian A.","family":"Koch","sequence":"additional","affiliation":[{"name":"Fox Chase Cancer Center, Philadelphia, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2020,8,7]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"2254","DOI":"10.1210\/jcem.84.8.5889","article-title":"Hypocalcemia induced during major and minor abdominal surgery in humans","volume":"84","author":"R Lepage","year":"1999","journal-title":"J Clin Endocrinol Metab"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1007\/s13193-016-0511-7","article-title":"Intensive care management of patient after cytoreductive surgery and HIPEC\n                    \u2013 A concise review","volume":"7","author":"A V Padmakumar","year":"2016","journal-title":"Indian J Surg Oncol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"P1","DOI":"10.1530\/EJE-18-0609","article-title":"Standards of care for hypoparathyroidism in adults: A Canadian and International\n                    Consensus","volume":"180","author":"A A Khan","year":"2019","journal-title":"Eur J Endocrinol"},{"issue":"S 01","key":"ref4","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.ygyno.2019.04.340","article-title":"Electrolyte and hematological abnormalities in patients with advanced epithelial\n                    ovarian cancers treated with cytoreductive surgery and hyperthermic\n                    intraperitoneal chemotherapy (CRS\/HIPEC) or neoadjuvant chemotherapy\n                    plus CRS\/HIPEC","volume":"154","author":"T P Diaz-Montes","year":"2019","journal-title":"Gynecol Oncol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1080\/02656736.2019.1597175","article-title":"Assessment of nephrotoxicity associated with combined cisplatin and mitomycin C\n                    usage in laparoscopic hyperthermic intraperitoneal chemotherapy","volume":"36","author":"R Kapoor","year":"2019","journal-title":"Int J Hyperther"},{"key":"ref6","first-page":"182","article-title":"Hypocalcemia \u2013 an adverse effect of massive blood transfusion\n                    examined","volume":"202","author":"G Birrer","year":"2016","journal-title":"J Surg Res"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1177\/0885066611411543","article-title":"Hypocalcemia in the critically Ill patient","volume":"28","author":"A Kelly","year":"2013","journal-title":"J Intens Care Med"},{"key":"ref8","first-page":"95","article-title":"Transient hypoparathyroidism in a patient with fever","volume":"44","author":"G Vervoort","year":"1994","journal-title":"Netherl J Med"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"14177","DOI":"10.1074\/jbc.M408587200","article-title":"Calcium sensing receptor gene transcription is up-regulated by the\n                    proinflammatory cytokine, interleukin-1B","volume":"280","author":"L Canaff","year":"2005","journal-title":"J Biol Chem"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"13586","DOI":"10.1074\/jbc.M708087200","article-title":"The proinflammatory cytokine, interleukin-6, upregulates calcium-sensing\n                    receptor gene transcription via Stat1\/3 and Sp1\/3","volume":"283","author":"L Canaff","year":"2008","journal-title":"J Biol Chem"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"1734","DOI":"10.1016\/j.ejso.2019.03.036","article-title":"Systemic inflammatory response after hyperthermic intraperitoneal chemotherapy\n                    (HIPC): The perfusion protocol matters!","volume":"45","author":"L Roth","year":"2019","journal-title":"Eur J Surg Oncol"},{"key":"ref12","first-page":"310","article-title":"Time course of cytokines, hemodynamic and metabolic parameters during\n                    hyperthermic intraperitoneal chemotherapy","volume":"82","author":"F Coccolini","year":"2016","journal-title":"Minerva Anestesiol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"244","DOI":"10.21037\/jgo.2018.12.09","article-title":"Inflammatory response and optimalisation of perioperative fluid administration\n                    during hyperthermic intraoperative intraperitoneal chemotherapy surgery","volume":"10","author":"P De Witte","year":"2019","journal-title":"J Gastrointest Oncol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1055\/a-0902-8476","article-title":"Long-term treatment with calcitriol in postsurgical hypoparathyroidism leads to\n                    renal function decline","volume":"51","author":"E Coudenys","year":"2019","journal-title":"Horm Metab Res"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1055\/a-1157-0511","article-title":"The effect of extracellular calcium metabolism on aldosterone biosynthesis in\n                    physiological and pathological status","volume":"52","author":"X Gao","year":"2020","journal-title":"Horm Metab Res"}],"container-title":["Hormone and Metabolic Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-1220-6971.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,10]],"date-time":"2020-09-10T22:38:19Z","timestamp":1599777499000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-1220-6971"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8,7]]},"references-count":15,"journal-issue":{"issue":"09","published-online":{"date-parts":[[2020,9,10]]},"published-print":{"date-parts":[[2020,9]]}},"URL":"https:\/\/doi.org\/10.1055\/a-1220-6971","relation":{},"ISSN":["0018-5043","1439-4286"],"issn-type":[{"value":"0018-5043","type":"print"},{"value":"1439-4286","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,8,7]]}}}