{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,3,30]],"date-time":"2022-03-30T16:17:12Z","timestamp":1648657032468},"reference-count":14,"publisher":"Georg Thieme Verlag KG","issue":"03","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pneumologie"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title><jats:p>Ein 47-j\u00e4hriger Patient mit langj\u00e4hrig bekanntem Asthma bronchiale, chronischer Rhinosinusitis und langj\u00e4hriger Epilepsie stellte sich aufgrund von progredienter Dyspnoe und Abgeschlagenheit in der pneumologischen Praxis vor. In einer thorakalen R\u00f6ntgenaufnahme und einer nachfolgend durchgef\u00fchrten thorakalen Computertomografie zeigten sich multiple pulmonale Rundherde.<\/jats:p><jats:p>Eine Bronchoskopie mit bronchoalveol\u00e4rer Lavage und transbronchialer Biopsie erbrachte den Befund einer eosinophilen Bronchitis und Alveolitis ohne Nachweis maligner Zellen. Nach Einleitung einer immunsuppressiven Therapie mit oralem Prednisolon und Umstellung der antikonvulsiven Therapie von Valproins\u00e4ure auf Levetiracetam besserten sich Dyspnoe und Belastbarkeit des Patienten binnen weniger Monate, einhergehend mit einem Regress der pulmonalen Rundherde und der peripheren Eosinophilie.<\/jats:p><jats:p>Eine pulmonale Eosinophilie erfordert eine gr\u00fcndliche differenzialdiagnostische Aufarbeitung. Bei diesem Patienten ist am ehesten von einer eosinophilen Granulomatose mit Polyangiitis auszugehen. In der Literatur finden sich aber auch Fallberichte zu Valproins\u00e4ure-induzierten eosinophilen Lungenerkrankungen, sodass auch hier eine Assoziation denkbar ist.<\/jats:p>","DOI":"10.1055\/a-1220-7149","type":"journal-article","created":{"date-parts":[[2020,9,14]],"date-time":"2020-09-14T22:38:33Z","timestamp":1600123113000},"page":"221-225","source":"Crossref","is-referenced-by-count":1,"title":["Eine seltene Ursache einer eosinophilen Lungenerkrankung"],"prefix":"10.1055","volume":"75","author":[{"given":"C.","family":"Stolpe","sequence":"additional","affiliation":[{"name":"Lungenpraxis Ibbenb\u00fcren, Ibbenb\u00fcren"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Tannapfel","sequence":"additional","affiliation":[{"name":"Georgius Agricola Stiftung Ruhr \u2013 Institut f\u00fcr Pathologie der Ruhr-Universit\u00e4t Bochum am Berufsgenossenschaftlichen Universit\u00e4tsklinikum Bergmannsheil, 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