{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,21]],"date-time":"2025-06-21T21:22:30Z","timestamp":1750540950837},"reference-count":39,"publisher":"Georg Thieme Verlag KG","issue":"06","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nuklearmedizin"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Objective\u2002To assess the patterns of recurrence of vulva cancer on 18F-FDG PET\/CT and to compare the 18F-FDG PET metabolic metrics in patients with and without Human Immunodeficiency Virus (HIV).<\/jats:p><jats:p>Methods\u2002Maximum standardized uptake value (SUVmax), mean standardized uptake value (SUVmean), metabolic tumour volume (MTV and total lesion glycolysis (TLG) were obtained on Flourine-18 Fluorodeoxyglucose Positron Emission Tomography\/Computed Tomography (18F-FDG PET\/CT) images of women referred with suspected or confirmed vulva cancer recurrence. We compared HIV-infected and HIV-uninfected patients regarding pattern disease recurrence, age at diagnosis, and the PET-derived metabolic indices.<\/jats:p><jats:p>Results\u2002We analyzed 33 patients with a mean age 50.76\u200a\u00b1 15.78 including 21 HIV-infected women. The majority of patients (94\u200a%) had squamous cell carcinoma and 84.85\u200a% were Blacks. Of the HIV-infected individuals, the median CD4 count was 526.0 cells\/mm3 (IQR: 379.0\u2013729.0). HIV infected patients were younger than the HIV uninfected at the time of diagnosis: 40.50\u200a\u00b1\u200a8.87 vs 66.54\u200a\u00b1\u200a9.71 respectively, p\u200a&lt;\u200a0.001. We found a local (vulvar) recurrence rate of 75.8\u200a%. Nodal pelvic recurrences were higher in the HIV-infected patients than in the HIV uninfected patients (70\u200a% vs 30\u200a%, p\u200a=\u200a0.027). Three patients had distant metastasis and all three were HIV-infected. There was a higher whole-body MTV and TLG among HIV-infected women compared with HIV-uninfected women, 103.39 vs 17.58 and 852.64 vs 101.79, respectively (p\u200a&lt;\u200a0.05 for both).<\/jats:p><jats:p>Conclusion\u2002HIV-infected women are diagnosed with vulva cancer at a younger age. HIV-infected patients had a higher rate of pelvic lymph node recurrence. There is a higher tumor burden at vulva cancer recurrence among women with HIV infection.<\/jats:p>","DOI":"10.1055\/a-1221-7810","type":"journal-article","created":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T23:05:47Z","timestamp":1599001547000},"page":"419-427","source":"Crossref","is-referenced-by-count":3,"title":["18F-FDG PET\/CT imaging of vulva cancer recurrence: A comparison of PET-derived metabolic parameters between women with and without HIV infection"],"prefix":"10.1055","volume":"59","author":[{"given":"Kgomotso M.G.","family":"Mokoala","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, University of Pretoria, Pretoria, South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ismaheel O.","family":"Lawal","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, University of Pretoria, Pretoria, South Africa"},{"name":"Nuclear Medicine Research Infrastructure (NuMeRI), Steve\u00a0Biko Academic Hospital, Pretoria, South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thabo","family":"Lengana","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, University of Pretoria, Pretoria, South Africa"},{"name":"KVNR Molecular Imaging, South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gbenga O.","family":"Popoola","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Community Health, University of Ilorin, Ilorin, Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tebatso M.G.","family":"Boshomane","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, University of Pretoria, Pretoria, South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neo P.","family":"Mokgoro","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, University of Pretoria, Pretoria, South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariza","family":"Vorster","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, University of Pretoria, Pretoria, South Africa"},{"name":"Nuclear Medicine Research Infrastructure (NuMeRI), Steve\u00a0Biko Academic Hospital, Pretoria, South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mike M.","family":"Sathekge","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, University of Pretoria, Pretoria, South Africa"},{"name":"Nuclear Medicine Research Infrastructure (NuMeRI), Steve\u00a0Biko Academic Hospital, Pretoria, South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2020,9,1]]},"reference":[{"issue":"S 02","key":"ref1","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1002\/ijgo.12609","article-title":"Cancer of the vulva","volume":"143","author":"L J 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