{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T08:34:07Z","timestamp":1740126847934,"version":"3.37.3"},"reference-count":51,"publisher":"Georg Thieme Verlag KG","issue":"01","funder":[{"name":"Federal Ministry of Education and Research (BMBF) to the German\n                        Center for Diabetes Research","award":["01GI0925"],"award-info":[{"award-number":["01GI0925"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Exp Clin Endocrinol Diabetes"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Prevalence of both type 1 and type 2 diabetes mellitus is growing worldwide and\n                    one major cause for morbidity and mortality. However, not every patient develops\n                    diabetes-related complications, but causes for the individual susceptibility are\n                    still not fully understood. As a platform to address this, we initiated the\n                    TUDID (TUebingen DIabetes Database) study, a prospective, monocentric,\n                    observational study that includes adults with diabetes mellitus who are treated\n                    in the inpatient clinic of a University Hospital in southern Germany. Besides a\n                    thorough clinical examination and extensive laboratory tests (with integrated\n                    biobanking), major study focuses are the kidneys, the eyes, the vasculature as\n                    well as cognition and mood where standardized investigations for early stages\n                    for diabetes complications are performed. Analyses of the data generated by this\n                    precise characterization of diabetes-related complications will contribute to\n                    our understanding of the development and course of such complications, and thus\n                    facilitate the implementation of tailored treatment options that can reduce the\n                    risk and severity of diabetes-related complications.<\/jats:p>","DOI":"10.1055\/a-1221-9618","type":"journal-article","created":{"date-parts":[[2020,9,10]],"date-time":"2020-09-10T22:48:03Z","timestamp":1599778083000},"page":"43-48","source":"Crossref","is-referenced-by-count":0,"title":["The TUDID Study \u2013 Background and Design of a Prospective\n                    Cohort"],"prefix":"10.1055","volume":"130","author":[{"given":"Benjamin Assad","family":"Jaghutriz","sequence":"additional","affiliation":[{"name":"Institute for Diabetes Research and Metabolic Diseases of the Helmholtz\n                    Center Munich at the University of T\u00fcbingen, T\u00fcbingen,\n                    Germany"},{"name":"German Center for Diabetes Research (DZD e.V.), T\u00fcbingen,\n                    Germany"},{"name":"Department of Internal Medicine, Division of Endocrinology,\n                    Diabetology, and Nephrology, University Hospital T\u00fcbingen,\n                    T\u00fcbingen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Wagner","sequence":"additional","affiliation":[{"name":"Institute for Diabetes Research and Metabolic Diseases of the Helmholtz\n                    Center Munich at the University of T\u00fcbingen, T\u00fcbingen,\n                    Germany"},{"name":"German Center for Diabetes Research (DZD e.V.), T\u00fcbingen,\n                    Germany"},{"name":"Department of Internal Medicine, Division of Endocrinology,\n                    Diabetology, and Nephrology, University Hospital T\u00fcbingen,\n                    T\u00fcbingen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephanie","family":"Kullmann","sequence":"additional","affiliation":[{"name":"Institute for Diabetes Research and Metabolic Diseases of the Helmholtz\n                    Center Munich at the University of T\u00fcbingen, T\u00fcbingen,\n                    Germany"},{"name":"German Center for Diabetes Research (DZD e.V.), T\u00fcbingen,\n                    Germany"},{"name":"Institute of Medical Psychology and Behavioral\n                    Neurobiology\/fMEG Center, Eberhard Karls University T\u00fcbingen,\n                    T\u00fcbingen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Louise","family":"Fritsche","sequence":"additional","affiliation":[{"name":"Institute for Diabetes Research and Metabolic Diseases of the Helmholtz\n                    Center Munich at the University of T\u00fcbingen, T\u00fcbingen,\n                    Germany"},{"name":"German Center for Diabetes Research (DZD e.V.), T\u00fcbingen,\n                    Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sabine S.","family":"Eckstein","sequence":"additional","affiliation":[{"name":"Institute for Diabetes Research and Metabolic Diseases of the Helmholtz\n                    Center Munich at the University of T\u00fcbingen, T\u00fcbingen,\n                    Germany"},{"name":"German Center for Diabetes Research (DZD e.V.), T\u00fcbingen,\n                    Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Corinna","family":"Dannecker","sequence":"additional","affiliation":[{"name":"Institute for Diabetes Research and Metabolic Diseases of the Helmholtz\n                    Center Munich at the University of T\u00fcbingen, T\u00fcbingen,\n                    Germany"},{"name":"German Center for Diabetes Research (DZD e.V.), T\u00fcbingen,\n                    Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caroline","family":"Willmann","sequence":"additional","affiliation":[{"name":"German Center for Diabetes Research (DZD e.V.), T\u00fcbingen,\n                    Germany"},{"name":"Department of Internal Medicine, Division of Endocrinology,\n                    Diabetology, and Nephrology, University Hospital T\u00fcbingen,\n                    T\u00fcbingen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elko","family":"Randrianarisoa","sequence":"additional","affiliation":[{"name":"Institute for Diabetes Research and Metabolic Diseases of the Helmholtz\n                    Center Munich at the University of T\u00fcbingen, T\u00fcbingen,\n                    Germany"},{"name":"German Center for Diabetes Research (DZD e.V.), T\u00fcbingen,\n                    Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angela","family":"Lehn-Stefan","sequence":"additional","affiliation":[{"name":"Institute for Diabetes Research and Metabolic Diseases of the Helmholtz\n                    Center Munich at the University of T\u00fcbingen, T\u00fcbingen,\n                    Germany"},{"name":"German Center for Diabetes Research (DZD e.V.), T\u00fcbingen,\n                    Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anja","family":"Hieronimus","sequence":"additional","affiliation":[{"name":"German Center for Diabetes Research (DZD e.V.), T\u00fcbingen,\n                    Germany"},{"name":"Department of Internal Medicine, Division of Endocrinology,\n                    Diabetology, and Nephrology, University Hospital T\u00fcbingen,\n                    T\u00fcbingen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah","family":"Hudak","sequence":"additional","affiliation":[{"name":"Institute for Diabetes Research and Metabolic Diseases of the Helmholtz\n                    Center Munich at the University of T\u00fcbingen, T\u00fcbingen,\n                    Germany"},{"name":"German Center for Diabetes Research (DZD e.V.), T\u00fcbingen,\n                    Germany"},{"name":"Department of Internal Medicine, Division of Endocrinology,\n                    Diabetology, and Nephrology, University Hospital T\u00fcbingen,\n                    T\u00fcbingen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dorothea","family":"Vosseler","sequence":"additional","affiliation":[{"name":"German Center for Diabetes Research (DZD e.V.), T\u00fcbingen,\n                    Germany"},{"name":"Department of Internal Medicine, Division of Endocrinology,\n                    Diabetology, and Nephrology, University Hospital T\u00fcbingen,\n                    T\u00fcbingen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Apostolia","family":"Lamprinou","sequence":"additional","affiliation":[{"name":"Institute for Diabetes Research and Metabolic Diseases of the Helmholtz\n                    Center Munich at the University of T\u00fcbingen, T\u00fcbingen,\n                    Germany"},{"name":"German Center for Diabetes Research (DZD e.V.), T\u00fcbingen,\n                    Germany"},{"name":"Department of Internal Medicine, Division of Endocrinology,\n                    Diabetology, and Nephrology, University Hospital T\u00fcbingen,\n                    T\u00fcbingen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philipp","family":"Huber","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Endocrinology,\n                    Diabetology, and Nephrology, University Hospital T\u00fcbingen,\n                    T\u00fcbingen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Vosseler","sequence":"additional","affiliation":[{"name":"Institute for Diabetes Research and Metabolic Diseases of the Helmholtz\n                    Center Munich at the University of T\u00fcbingen, T\u00fcbingen,\n                    Germany"},{"name":"German Center for Diabetes Research (DZD e.V.), T\u00fcbingen,\n                    Germany"},{"name":"Department of Internal Medicine, Division of Endocrinology,\n                    Diabetology, and Nephrology, University Hospital T\u00fcbingen,\n                    T\u00fcbingen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriel","family":"Willmann","sequence":"additional","affiliation":[{"name":"University Eye Hospital T\u00fcbingen, T\u00fcbingen,\n                    Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nils","family":"Heyne","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Endocrinology,\n                    Diabetology, and Nephrology, University Hospital T\u00fcbingen,\n                    T\u00fcbingen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diana","family":"Wolff","sequence":"additional","affiliation":[{"name":"Department of Conservative Dentistry, University Hospital\n                    T\u00fcbingen, T\u00fcbingen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norbert","family":"Stefan","sequence":"additional","affiliation":[{"name":"Institute for Diabetes Research and Metabolic Diseases of the Helmholtz\n                    Center Munich at the University of T\u00fcbingen, T\u00fcbingen,\n                    Germany"},{"name":"German Center for Diabetes Research (DZD e.V.), T\u00fcbingen,\n                    Germany"},{"name":"Department of Internal Medicine, Division of Endocrinology,\n                    Diabetology, and Nephrology, University Hospital T\u00fcbingen,\n                    T\u00fcbingen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans-Ulrich","family":"H\u00e4ring","sequence":"additional","affiliation":[{"name":"Institute for Diabetes Research and Metabolic Diseases of the Helmholtz\n                    Center Munich at the University of T\u00fcbingen, T\u00fcbingen,\n                    Germany"},{"name":"German Center for Diabetes Research (DZD e.V.), T\u00fcbingen,\n                    Germany"},{"name":"Department of Internal Medicine, Division of Endocrinology,\n                    Diabetology, and Nephrology, University Hospital T\u00fcbingen,\n                    T\u00fcbingen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas L.","family":"Birkenfeld","sequence":"additional","affiliation":[{"name":"Institute for Diabetes Research and Metabolic Diseases of the Helmholtz\n                    Center Munich at the University of T\u00fcbingen, T\u00fcbingen,\n                    Germany"},{"name":"German Center for Diabetes Research (DZD e.V.), T\u00fcbingen,\n                    Germany"},{"name":"Department of Internal Medicine, Division of Endocrinology,\n                    Diabetology, and Nephrology, University Hospital T\u00fcbingen,\n                    T\u00fcbingen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Peter","sequence":"additional","affiliation":[{"name":"Institute for Diabetes Research and Metabolic Diseases of the Helmholtz\n                    Center Munich at the University of T\u00fcbingen, T\u00fcbingen,\n                    Germany"},{"name":"German Center for Diabetes Research (DZD e.V.), T\u00fcbingen,\n                    Germany"},{"name":"Institute for Clinical Chemistry and Pathobiochemistry, Department for\n                    Diagnostic Laboratory Medicine, University Hospital T\u00fcbingen,\n                    T\u00fcbingen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4987-1961","authenticated-orcid":false,"given":"Andreas","family":"Fritsche","sequence":"additional","affiliation":[{"name":"Institute for Diabetes Research and Metabolic Diseases of the Helmholtz\n                    Center Munich at the University of T\u00fcbingen, T\u00fcbingen,\n                    Germany"},{"name":"German Center for Diabetes Research (DZD e.V.), T\u00fcbingen,\n                    Germany"},{"name":"Department of Internal Medicine, Division of Endocrinology,\n                    Diabetology, and Nephrology, University Hospital T\u00fcbingen,\n                    T\u00fcbingen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8462-3832","authenticated-orcid":false,"given":"Martin","family":"Heni","sequence":"additional","affiliation":[{"name":"Institute for Diabetes Research and Metabolic Diseases of the Helmholtz\n                    Center Munich at the University of T\u00fcbingen, T\u00fcbingen,\n                    Germany"},{"name":"German Center for Diabetes Research (DZD e.V.), T\u00fcbingen,\n                    Germany"},{"name":"Department of Internal Medicine, Division of Endocrinology,\n                    Diabetology, and Nephrology, University Hospital T\u00fcbingen,\n                    T\u00fcbingen, Germany"},{"name":"Institute for Clinical Chemistry and Pathobiochemistry, Department for\n                    Diagnostic Laboratory Medicine, University Hospital T\u00fcbingen,\n                    T\u00fcbingen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2020,9,10]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1038\/nrendo.2017.151","article-title":"Global aetiology and epidemiology of type 2 diabetes mellitus and its\n                    complications","volume":"14","author":"Y Zheng","year":"2018","journal-title":"Nat Rev Endocrinol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.2522\/ptj.20080020","article-title":"Epidemiology of diabetes and diabetes-related complications","volume":"88","author":"A D Deshpande","year":"2008","journal-title":"Phys Ther"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"832","DOI":"10.2337\/diacare.26.3.832","article-title":"\u03b2-cell function and the development of diabetes-related complications in\n                    the diabetes control and complications trial","volume":"26","author":"M W Steffes","year":"2003","journal-title":"Diabetes Care"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1038\/ncpneuro0504","article-title":"Diabetic neuropathy\u2014a review","volume":"3","author":"G Said","year":"2007","journal-title":"Nat Rev Neurol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1518","DOI":"10.2337\/dc05-2228","article-title":"The prevalence, severity, and impact of painful diabetic peripheral neuropathy\n                    in type 2 diabetes","volume":"29","author":"M Davies","year":"2006","journal-title":"Diabetes Care"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"136","DOI":"10.2337\/dc16-2042","article-title":"Diabetic Neuropathy: A Position Statement by the American Diabetes\n                    Association","volume":"40","author":"R Pop-Busui","year":"2017","journal-title":"Diabetes Care"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1038\/ncpendmet0894","article-title":"The pathogenesis of diabetic nephropathy","volume":"4","author":"S Dronavalli","year":"2008","journal-title":"Nat Rev Endocrinol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"2864","DOI":"10.2337\/dc14-1296","article-title":"Diabetic Kidney Disease: A Report From an ADA Consensus Conference","volume":"37","author":"K R Tuttle","year":"2014","journal-title":"Diabetes Care"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"556","DOI":"10.2337\/dc11-1909","article-title":"Global Prevalence and Major Risk Factors of Diabetic Retinopathy","volume":"35","author":"JW Y Yau","year":"2012","journal-title":"Diabetes Care"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1111\/ceo.12696","article-title":"Diabetic retinopathy: Global prevalence, major risk factors, screening practices\n                    and public health challenges: a review","volume":"44","author":"DS W Ting","year":"2016","journal-title":"Clin Experiment Ophthalmol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1136\/bjophthalmol-2013-304017","article-title":"Prevalence of diabetic retinopathy within a national diabetic retinopathy\n                    screening service","volume":"99","author":"R L Thomas","year":"2015","journal-title":"Br J Ophthalmol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"1629","DOI":"10.1056\/NEJMra1909637","article-title":"Evaluation and care of patients with diabetic retinopathy","volume":"382","author":"L M Jampol","year":"2020","journal-title":"N Engl J Med"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1001\/jamaophthalmol.2017.0988","article-title":"Association of Diabetic Macular Edema and Proliferative Diabetic Retinopathy\n                    With Cardiovascular Disease: A systematic review and meta-analysis","volume":"135","author":"J Xie","year":"2017","journal-title":"JAMA Ophthalmol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"3026","DOI":"10.1161\/01.CIR.94.11.3026","article-title":"Diagnosis and Treatment of Chronic Arterial Insufficiency of the Lower\n                    Extremities: A Critical Review","volume":"94","author":"I Weitz Jeffrey","year":"1996","journal-title":"Circulation"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1016\/j.jacc.2005.09.065","article-title":"Peripheral Arterial Disease in Patients With Diabetes","volume":"47","author":"S P Marso","year":"2006","journal-title":"J Am Coll Cardiol"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.3402\/dfa.v3i0.18409","article-title":"Diabetic foot infections: Current concept review","volume":"3","author":"K B Hobizal","year":"2012","journal-title":"Diabet Foot Ankle"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/S1474-4422(14)70249-2","article-title":"Cognitive function in patients with diabetes mellitus: Guidance for daily\n                    care","volume":"14","author":"P S Koekkoek","year":"2015","journal-title":"Lancet Neurol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.ijdm.2011.01.001","article-title":"Cognitive impairment in type 2 diabetes mellitus","volume":"3","author":"MA H Hazari","year":"2015","journal-title":"Int J Diabetes Mellit"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.2337\/dc14-2319","article-title":"Selective insulin resistance in homeostatic and cognitive control brain areas in\n                    overweight and obese adults","volume":"38","author":"S Kullmann","year":"2015","journal-title":"Diabetes Care"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"1768","DOI":"10.2337\/dc15-0041","article-title":"Clinically relevant cognitive impairment in middle-aged adults with\n                    childhood-onset type 1 diabetes","volume":"38","author":"K A Nunley","year":"2015","journal-title":"Diabetes Care"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1001\/archneur.64.4.570","article-title":"Relation of Diabetes to Mild Cognitive Impairment","volume":"64","author":"J A Luchsinger","year":"2007","journal-title":"Arch Neurol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.2337\/diacare.24.6.1069","article-title":"The Prevalence of Comorbid Depression in Adults With Diabetes: A\n                    meta-analysis","volume":"24","author":"R J Anderson","year":"2001","journal-title":"Diabetes Care"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"333","DOI":"10.2147\/DMSO.S106797","article-title":"Depression in people with type 2 diabetes: Current perspectives","volume":"11","author":"L Darwish","year":"2018","journal-title":"Diabetes Metab Syndr Obes Targets Ther"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1111\/jcpe.12808","article-title":"Scientific evidence on the links between periodontal diseases and diabetes:\n                    Consensus report and guidelines of the joint workshop on periodontal diseases\n                    and diabetes by the International Diabetes Federation and the European\n                    Federation of Periodontology","volume":"45","author":"M Sanz","year":"2018","journal-title":"J Clin Periodontol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"329","DOI":"10.2337\/diacare.16.1.329","article-title":"Periodontal Disease: The sixth complication of diabetes mellitus","volume":"16","author":"H L\u00f6e","year":"1993","journal-title":"Diabetes Care"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1111\/prd.12318","article-title":"The impact of diabetes on periodontal diseases","volume":"82","author":"D T 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Medical Care in\n                    Diabetes\u20142018","volume":"41","year":"2018","journal-title":"Diabetes Care"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.2337\/diacare.17.11.1281","article-title":"A practical two-step quantitative clinical and electrophysiological assessment\n                    for the diagnosis and staging of diabetic neuropathy","volume":"17","author":"E L Feldman","year":"1994","journal-title":"Diabetes Care"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1111\/j.1464-5491.2012.03644.x","article-title":"Use of the Michigan Neuropathy Screening Instrument as a measure of distal\n                    symmetrical peripheral neuropathy in Type 1 diabetes: Results from the Diabetes\n                    Control and Complications Trial\/Epidemiology of Diabetes Interventions\n                    and Complications","volume":"29","author":"W H Herman","year":"2012","journal-title":"Diabet Med J Br Diabet Assoc"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/j.clineuro.2005.08.003","article-title":"Validation of Michigan neuropathy screening instrument for diabetic peripheral\n                    neuropathy","volume":"108","author":"A Moghtaderi","year":"2006","journal-title":"Clin Neurol Neurosurg"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1016\/j.clnu.2011.04.001","article-title":"Accuracy of direct segmental multi-frequency bioimpedance analysis in the\n                    assessment of total body and segmental body composition in middle-aged adult\n                    population","volume":"30","author":"CH Y Ling","year":"2011","journal-title":"Clin Nutr"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1016\/j.cjca.2012.06.014","article-title":"Diagnostic Value of ankle-brachial index in peripheral arterial disease: A\n                    meta-analysis","volume":"29","author":"D 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