{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T18:10:12Z","timestamp":1790791812336,"version":"4.1.0"},"reference-count":49,"publisher":"Georg Thieme Verlag KG","issue":"03","license":[{"start":{"date-parts":[[2021,1,28]],"date-time":"2021-01-28T00:00:00Z","timestamp":1611792000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Geburtshilfe Frauenheilkd"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Background The rate of preterm births in Germany is 8.6%, which is very high compared to other European countries. As preterm birth contributes significantly to perinatal morbidity and mortality rates, the existing prevention strategies need to be optimized and expanded further. About \u2154 of all women with preterm birth have preterm labor or premature rupture of membranes. They are bracketed together under the term \u201cspontaneous preterm birth\u201d as opposed to iatrogenic preterm birth, for example as a consequence of preeclampsia or fetal growth retardation. Recent studies suggest that low-dose aspirin does not just reduce the rate of iatrogenic preterm births but can also further reduce the rate of spontaneous preterm births. This review article presents the current state of knowledge.<\/jats:p><jats:p>\n          Method A selective literature search up until April 2020 was done in PubMed, using the terms \u201crandomized trial\u201d, \u201crandomized study\u201d, \u201cspontaneous preterm birth\u201d, and \u201caspirin\u201d.<\/jats:p><jats:p>\n          Results Secondary analyses of prospective randomized studies on the prevention of preeclampsia with low-dose aspirin show that this intervention also significantly reduced the rate of spontaneous preterm births in both high-risk and low-risk patient populations. The results of the ASPIRIN trial, a prospective, randomized, double-blinded multicenter study carried out in six developing countries, also point in this direction, with the figures showing that the daily administration of 81\u2009mg aspirin starting before 14 weeks of gestation lowered the preterm birth rate of nulliparous women without prior medical conditions by around 11% (11.6 vs. 13.1%; RR 0.89; 95% CI: 0.81\u200a\u2013\u200a0.98, p\u2009=\u20090.012).<\/jats:p><jats:p>\n          Conclusion Further studies on this issue are urgently needed. If these confirm the currently available results, then it would be worth discussing whether general aspirin prophylaxis for all pregnant women starting at the latest in 12 weeks of gestation is indicated.<\/jats:p>","DOI":"10.1055\/a-1226-6599","type":"journal-article","created":{"date-parts":[[2021,1,29]],"date-time":"2021-01-29T06:29:03Z","timestamp":1611901743000},"page":"304-310","source":"Crossref","is-referenced-by-count":10,"title":["Spontaneous Preterm Birth: Is Prevention with Aspirin Possible?"],"prefix":"10.1055","volume":"81","author":[{"given":"Richard","family":"Berger","sequence":"additional","affiliation":[{"name":"Marienhaus Klinikum St.\u00a0Elisabeth, Klinik f\u00fcr Gyn\u00e4kologie und Geburtshilfe, Neuwied, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ioannis","family":"Kyvernitakis","sequence":"additional","affiliation":[{"name":"Asklepios Kliniken Barmbek, Wandsbek und Nord-Heidberg, Frauenkliniken, Hamburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Holger","family":"Maul","sequence":"additional","affiliation":[{"name":"Asklepios Kliniken Barmbek, Wandsbek und Nord-Heidberg, Frauenkliniken, Hamburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2021,1,28]]},"reference":[{"key":"ref2","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1126\/science.1251816","article-title":"Preterm labor: one syndrome, many causes","volume":"345","author":"R Romero","year":"2014","journal-title":"Science"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.ajog.2017.11.561","article-title":"Aspirin for the prevention of preterm and term preeclampsia: systematic review and metaanalysis","volume":"218","author":"S Roberge","year":"2018","journal-title":"Am J Obstet Gynecol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.ajog.2016.09.076","article-title":"The role of aspirin dose on the prevention of preeclampsia and fetal growth restriction: systematic review and meta-analysis","volume":"216","author":"S Roberge","year":"2017","journal-title":"Am J Obstet Gynecol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1002\/uog.12421","article-title":"Prevention of perinatal death and adverse perinatal outcome using low-dose aspirin: a meta-analysis","volume":"41","author":"S Roberge","year":"2013","journal-title":"Ultrasound Obstet Gynecol"},{"issue":"02","key":"ref6","first-page":"CD004659","article-title":"Antiplatelet agents for preventing pre-eclampsia and its complications","author":"L Duley","year":"2007","journal-title":"Cochrane Database Syst Rev"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1016\/S0140-6736(94)92633-6","article-title":"CLASP: a randomised trial of low-dose aspirin for the prevention and treatment of pre-eclampsia among 9364 pregnant women. 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