{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T12:53:00Z","timestamp":1756385580575},"reference-count":15,"publisher":"Georg Thieme Verlag KG","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Horm Metab Res"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Idiopathic hypoparathyroidism leads to hypocalcemia and hyperphosphatasemia and\nusually has a genetic aetiology. The variable but often subtle signs and\nsymptoms usually lead to a misdiagnosis of hypoparathyroidism. Case records of\n32 patients of idiopathic hypoparathyroidism admitted over a period of five\nyears were analysed. There was a lag period of 5.94 years from the onset of\nsymptoms to the diagnosis. Carpopedal spasm was the most common indication for\nadmission to the hospital. Trivial symptoms such as fatigue (84%) and\nparesthesia (62.5%) were the most common reported symptoms. A sum of\n46.5% of the patients were on antiepileptic drugs before the correct\ndiagnosis of hypoparathyroidism was made. This observation emphasized that\nCalcium profile should be obtained in patients with history of paresthesia and\nseizure to avoid the long delay in diagnosis of hypoparathyroidism.<\/jats:p>","DOI":"10.1055\/a-1228-8199","type":"journal-article","created":{"date-parts":[[2020,9,4]],"date-time":"2020-09-04T22:38:10Z","timestamp":1599259090000},"page":"708-711","source":"Crossref","is-referenced-by-count":3,"title":["Idiopathic Hypoparathyroidism: Still a Diagnostic Conundrum \u2013\nA Tertiary Centre Experience"],"prefix":"10.1055","volume":"52","author":[{"given":"Rujul","family":"Jain","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Institute of Medical\nSciences, Banaras Hindu University, Varanasi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. K.","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Institute of Medical\nSciences, Banaras Hindu University, Varanasi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N. K.","family":"Agrawal","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Institute of Medical\nSciences, Banaras Hindu University, Varanasi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2020,9,4]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"2317","DOI":"10.1002\/jbmr.483","article-title":"Hypoparathyroidism in the adult: epidemiology, diagnosis, pathophysiology,\ntarget-organ involvement, treatment, and challenges for future research","volume":"26","author":"J P Bilezikian","year":"2011","journal-title":"J Bone Miner Res"},{"key":"ref2","first-page":"S182","article-title":"Co-morbid- medical conditions associated with prevalent hypoparathyroidism: A\npopulation-based study","volume":"26","author":"B L Clarke","year":"2011","journal-title":"J Bone Miner Res"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1056\/NEJMcp0803050","article-title":"Clinical practice. Hypoparathyroidism","volume":"359","author":"D Shoback","year":"2008","journal-title":"N Engl J Med"},{"key":"ref4","first-page":"938","article-title":"Idiopathic hypoparathyroidism with extensive intracranial calcification\nassociated with kinesogenic choreoathetosis","volume":"48","author":"A S Girija","year":"2000","journal-title":"J Assoc Physicians India"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1097\/MED.0b013e3283591502","article-title":"Hypoparathyroidism: From diagnosis to treatment","volume":"19","author":"V De Sanctis","year":"2012","journal-title":"Curr Opin Endocrinol Diabetes Obes"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"2277","DOI":"10.1002\/jbmr.1979","article-title":"Cardiovascular and renal complications to postsurgical hypoparathyroidism: A\nDanish nationwide controlled historic follow-up study","volume":"28","author":"L Underbjerg","year":"2013","journal-title":"J Bone Miner Res"},{"key":"ref7","first-page":"169","article-title":"Analysis of eighteen cases with hypoparathyroidism misdiagnosed as primary\nepilepsy","volume":"10","author":"H F Niu","year":"2007","journal-title":"Chin J Pract Nervous Dis"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1016\/j.beem.2011.07.001","article-title":"Disorders of calcium metabolism and parathyroid disease","volume":"25","author":"M S Cooper","year":"2011","journal-title":"Best Pract Res Clin Endocrinol Metab"},{"key":"ref9"},{"key":"ref10","first-page":"586","volume":"59","author":"S K Bhadada","year":"2011","journal-title":"Spectrum of neurological manifestations of idiopathic\nhypoparathyroidism and pseudohypoparathyroidism. Neurol India"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1111\/j.0954-6820.1978.tb14860.x","article-title":"Hypocalcaemia with zonular cataract due to idiopathic hypoparathyroidism","volume":"203","author":"B Philipson","year":"1978","journal-title":"Acta Medica Scand"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1111\/j.1755-3768.1962.tb02365.x","article-title":"Ocular manifestations of idiopathic hypoparathyroidism","volume":"40","author":"S Pohjola","year":"1962","journal-title":"Acta Ophthalmol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"1741","DOI":"10.1210\/jc.2013-3863","article-title":"Expression of osteogenic molecules in the caudate nucleus and gray matter and\ntheir potential relevance for basal ganglia calcification in\nhypoparathyroidism","volume":"99","author":"R Goswami","year":"2014","journal-title":"J Clin Endocrinol Metab"},{"key":"ref14","first-page":"9","article-title":"Misdiagnosis of idiopathic hypoparathyroidism: A case report and literature\nreview","volume":"97","author":"L Li","year":"2018","journal-title":"Medicine"},{"key":"ref15","first-page":"63","article-title":"Analysis of two cases with hypoparathyroidism misdiagnosed as idiopathic basal\nganglia calcification","volume":"28","author":"J F Lou","year":"2007","journal-title":"GiLin Med J"}],"container-title":["Hormone and Metabolic Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-1228-8199.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,10,13]],"date-time":"2020-10-13T22:37:15Z","timestamp":1602628635000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-1228-8199"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9,4]]},"references-count":15,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2020,10,13]]},"published-print":{"date-parts":[[2020,10]]}},"URL":"https:\/\/doi.org\/10.1055\/a-1228-8199","relation":{},"ISSN":["0018-5043","1439-4286"],"issn-type":[{"value":"0018-5043","type":"print"},{"value":"1439-4286","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,9,4]]}}}