{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T02:41:27Z","timestamp":1792636887979,"version":"4.5.0"},"reference-count":16,"publisher":"Georg Thieme Verlag KG","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Z Gastroenterol"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Background\u2002Neurological autoimmune disorders (NAD) are caused by autoimmune inflammation triggered by specific antibody subtypes. NAD\u200amay disturb the gut-brain axis at\u00a0several levels including brain, spinal cord, peripheral, or enteric nervous system.<\/jats:p><jats:p>\n          Case report\u2002We present a case with antinuclear neuronal Hu (ANNA-1)- and antiglial nuclear (SOX-1) autoimmune antibody-positive limbic encephalitis and significant gastrointestinal dysmotility consisting of achalasia type II, gastroparesis, altered small intestinal interdigestive motility, and severe slow transit constipation. The autoantibodies of the patient\u2019s serum labeled enteric neurons and interstitial cells of Cajal but no other cells in the gut wall. Achalasia was treated successfully by pneumatic cardia dilation and gastrointestinal dysmotility successfully with prucalopride.<\/jats:p><jats:p>\n          Conclusion\u2002NAD\u200amay disturb gastrointestinal motility by altering various levels of the gut-brain axis.<\/jats:p>","DOI":"10.1055\/a-1233-2190","type":"journal-article","created":{"date-parts":[[2020,10,9]],"date-time":"2020-10-09T22:38:50Z","timestamp":1602283130000},"page":"975-981","source":"Crossref","is-referenced-by-count":6,"title":["Autoimmune encephalitis and gastrointestinal dysmotility: achalasia, gastroparesis, and slow transit constipation"],"prefix":"10.1055","volume":"58","author":[{"given":"Thomas","family":"Frieling","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Gastroenterology, HELIOS Clinic Krefeld, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Kreysel","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Gastroenterology, HELIOS Clinic Krefeld, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Blank","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Gastroenterology, HELIOS Clinic Krefeld, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dorothee","family":"M\u00fcller","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Gastroenterology, HELIOS Clinic Krefeld, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilka","family":"Melchior","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Gastroenterology, HELIOS Clinic Krefeld, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philipp","family":"Euler","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Gastroenterology, HELIOS Clinic Krefeld, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rita","family":"Kuhlbusch-Zicklam","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Gastroenterology, HELIOS Clinic Krefeld, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Haarmeier","sequence":"additional","affiliation":[{"name":"Department of Neurology, HELIOS Clinic Krefeld, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Schemann","sequence":"additional","affiliation":[{"name":"Human Biology, technical University Munich, Freising, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2020,10,9]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1159\/000505810","article-title":"The brain-gut team","volume":"38","author":"J R Malagelada","year":"2020","journal-title":"Dig Dis"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"e13611","DOI":"10.1111\/nmo.13611","article-title":"Neurological autoimmune disorders with prominent gastrointestinal manifestations: a review of presentation, evaluation, and treatment","volume":"31","author":"K M Blackburn","year":"2019","journal-title":"Neurogastroenterol Motil"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"E529","DOI":"10.1503\/cmaj.181548","volume":"191","author":"A Budhram","year":"2019","journal-title":"CMAJ"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.3174\/ajnr.A5086","article-title":"Autoimmune encephalitis: pathophysiology and imaging. 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