{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T02:29:14Z","timestamp":1788402554195,"version":"build-2803163510"},"reference-count":38,"publisher":"Georg Thieme Verlag KG","issue":"03","funder":[{"name":"National Research Foundation of Korea (NRF) grant funded by the Korea government","award":["NRF-2017R1C1B5017867 & 2020R1F1A1075613"],"award-info":[{"award-number":["NRF-2017R1C1B5017867 & 2020R1F1A1075613"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Sports Med"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The purpose of this study was to examine the differences in neuromuscular control and mechanical properties of the ankle-stabilizing muscles between men and women, and during different phases of menstrual cycle in women. Fifteen women with regular menstrual cycles and 17 male counterparts were included in this study. Electromyographic signals were recorded from the peroneus longus (PL) and tibialis anterior (TA) muscles while performing three balance tasks. Muscle tone, stiffness, and elasticity of muscles were measured using a MyotonPRO in the resting position. Outcomes were measured twice (ovulation and early follicular phases) for women, while measurements were acquired only once for men. Significantly higher tibialis anterior-peroneus longus co-contraction (TA\/PL ratio) was observed in all balance tasks in women than in men (p&lt; 0.05); however, significant differences between phases of the menstrual cycle were noted only in the 2 most difficult tasks (p&lt; 0.05). A similar pattern was observed in the postural sway. These results highlight the importance of sex-specific hormonal effects on neuromuscular control and mechanical properties, and as well as the differences during phases of the menstrual cycle. These insights assume significance in the context of developing neuromuscular strategies for the purpose of preventing lower extremity injuries during sports activities.<\/jats:p>","DOI":"10.1055\/a-1236-3654","type":"journal-article","created":{"date-parts":[[2020,9,13]],"date-time":"2020-09-13T18:31:01Z","timestamp":1600021861000},"page":"270-276","source":"Crossref","is-referenced-by-count":17,"title":["Neuromuscular Control of Ankle-stabilizing Muscles-specific Effects of Sex and Menstrual Cycle"],"prefix":"10.1055","volume":"42","author":[{"given":"Iman Akef","family":"Khowailed","sequence":"additional","affiliation":[{"name":"University of St Augustine for Health Sciences, College of Rehabilitative Sciences San Marcos California Campus"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haneul","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Physical Therapy, Gachon University - Medical Campus, Incheon, Korea (the Republic 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young athletes","volume":"14","author":"R W Smith","year":"1986","journal-title":"Am J Sports Med"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1177\/0363546504268137","article-title":"Intrinsic risk factors for inversion ankle sprains in male subjects: A prospective study","volume":"33","author":"T M Willems","year":"2005","journal-title":"Am J Sports Med"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1111\/j.1600-0838.2004.00428.x","article-title":"Intrinsic risk factors for inversion ankle sprains in females\u2013a prospective study","volume":"15","author":"T M Willems","year":"2005","journal-title":"Scand J Med Sci Sports"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1016\/j.jsams.2007.05.005","article-title":"The effects of gender and pubertal status on generalized joint laxity in young athletes","volume":"11","author":"C E Quatman","year":"2008","journal-title":"J Sci Med 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