{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T17:28:54Z","timestamp":1770226134607,"version":"3.49.0"},"reference-count":40,"publisher":"Georg Thieme Verlag KG","issue":"05","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tierarztl Prax Ausg K Kleintiere Heimtiere"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title><jats:p>Ein 10\u2005Monate alter, m\u00e4nnlich intakter Rhodesian Ridgeback wurde wegen chronischen Dickdarmdurchfalls und H\u00e4matochezie vorgestellt. Der Hund stammte aus Deutschland und hatte das Land nie verlassen. Die Laboruntersuchung des vorbehandelnden Tierarztes ergab neben einer Neutrophilie eine Hyperkali\u00e4mie und eine Hyponatri\u00e4mie. Mit einem Serumbasalkortisolwert von 4,3\u2005\u00b5g\/dl konnte ein Hypoadrenokortizismus weitgehend ausgeschlossen werden. Eine vom Tierarzt durch gef\u00fchrte antibiotische Behandlung hatte keine Besserung bewirkt. Daher war der Hund mit Prednisolon behandelt worden. Unter 2-w\u00f6chiger Prednisolongabe kam es zu einer deutlichen Verst\u00e4rkung des Durchfalls sowie einem Gewichtsverlust von 6\u2005kg. Bei Vorstellung an der Medizinischen Kleintierklinik der LMU M\u00fcnchen war der Hund im Allgemeinbefinden mittelgradig reduziert, deutlich abgemagert, dehydriert, hypovol\u00e4misch und hatte eine rektale K\u00f6rpertemperatur von 39,6\u2005\u00b0C. Bei der sonografischen Untersuchung zeigte sich eine generalisiert verdickte Dickdarmwand und koloskopisch eine hochgradig ulzerativ ver\u00e4nderte Dickdarmschleimhaut. Histologischer Befund war eine ulzerative granulomat\u00f6se Kolitis. Durch die Periodic-Acid-Schiff-Reaktion lie\u00dfen sich in den Schnitten der Dickdarmbioptate mikrobielle Strukturen darstellen, die f\u00fcr eine Algeninfektion diagnostisch waren. Die bei der mikrobiellen Untersuchung anz\u00fcchtbaren Prototheken wurden mittels MALDI-TOF-MS als Prototheca zopfii identifiziert. Zum Nachweis einer m\u00f6glichen Immundefizienz wurden die Immunglobuline im Serum bestimmt. Die IgM-Konzentration war erniedrigt, w\u00e4hrend sich IgG- und IgA-Konzentration im Referenzbereich befanden. Aufgrund der Verschlechterung des Allgemeinbefindens, der vorsichtigen Prognose und der hohen Kosten eines Therapieversuchs wurde der Hund eine Woche sp\u00e4ter euthanasiert und der Tierk\u00f6rper pathologisch untersucht. Histopathologisch wurden Prototheken auch in den abdominalen Lymphknoten, jedoch nicht in den Augen oder im zentralen Nervensystem identifiziert. Der Fall zeigt, dass eine Prototheken-Infektion auch bei Hunden aus Deutschland als Differenzialdiagnose f\u00fcr chronischen Dickdarmdurchfall in Betracht gezogen werden sollte, insbesondere bei Patienten mit ulzerativer granulomat\u00f6ser Kolitis. Sie kann bei der histologischen Untersuchung ohne Spezialf\u00e4rbung leicht \u00fcbersehen werden.<\/jats:p>","DOI":"10.1055\/a-1238-1554","type":"journal-article","created":{"date-parts":[[2020,10,21]],"date-time":"2020-10-21T22:37:46Z","timestamp":1603319866000},"page":"369-375","source":"Crossref","is-referenced-by-count":2,"title":["Ulzerative granulomat\u00f6se Kolitis durch Prototheca spp. bei einem Rhodesian Ridgeback in Deutschland"],"prefix":"10.1055","volume":"48","author":[{"given":"Vera","family":"Geisen","sequence":"additional","affiliation":[{"name":"Medizinische Kleintierklinik, Zentrum f\u00fcr Klinische Tiermedizin, Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Mayer","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Tierpathologie, Zentrum f\u00fcr Klinische Tiermedizin, Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julia","family":"Harrer","sequence":"additional","affiliation":[{"name":"Medizinische Kleintierklinik, Zentrum f\u00fcr Klinische Tiermedizin, Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katrin","family":"Hartmann","sequence":"additional","affiliation":[{"name":"Medizinische Kleintierklinik, Zentrum f\u00fcr Klinische Tiermedizin, Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sebastian","family":"Ulrich","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Infektionsmedizin und Zoonosen, Veterin\u00e4rwissenschaftliches Department, Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan","family":"Unterer","sequence":"additional","affiliation":[{"name":"Medizinische Kleintierklinik, Zentrum f\u00fcr Klinische Tiermedizin, Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2020,10,21]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1016\/S0195-5616(00)05008-7","article-title":"Canine protothecosis","volume":"30","author":"S R Hollingsworth","year":"2000","journal-title":"Vet Clin North Am Small Anim Pract"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1080\/13695780310001653653","article-title":"Protothecosis","volume":"42","author":"B C Leimann","year":"2004","journal-title":"Med Mycol"},{"key":"ref3","first-page":"158","article-title":"Protothecosis with ocular involvement in a dog","volume":"167","author":"N Buyukmihci","year":"1975","journal-title":"J\u202fAm Vet Med Assoc"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1292\/jvms.66.593","article-title":"A case report of 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