{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T23:52:06Z","timestamp":1788306726550,"version":"build-2803163510"},"reference-count":77,"publisher":"Georg Thieme Verlag KG","issue":"10","license":[{"start":{"date-parts":[[2020,10,13]],"date-time":"2020-10-13T00:00:00Z","timestamp":1602547200000},"content-version":"vor","delay-in-days":12,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Horm Metab Res"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Association between vitamin D and uric acid is complex and might be\n                    bidirectional. Our study aimed to determine the bidirectional association\n                    between vitamin D and uric acid in adults. Using MEDLINE via PubMed and Scopus,\n                    we systematically searched for observational or interventional studies in\n                    adults, which assessed the association between serum vitamin D and serum uric\n                    acid, extracted the data, and conducted analysis by direct and network\n                    meta-analysis. The present review included 32 studies, of which 21 had vitamin D\n                    as outcome and 11 had uric acid as outcome. Meta-analysis showed a significant\n                    pooled beta coefficient of serum uric acid level on serum 25(OH)D level from 3\n                    studies of 0.512 (95% confidence interval: 0.199, 0.825) and a\n                    significant pooled odds ratio between vitamin D deficiency and hyperuricemia of\n                    1.496 (1.141, 1.963). The pooled mean difference of serum 25(OH)D between groups\n                    with hyperuricemia and normouricemia was non-significant at 0.138\n                    (\u22120.430, 0.707) ng\/ml, and the pooled mean difference of serum\n                    uric acid between categories of 25(OH)D were also non-significant at 0.072\n                    (\u22120.153, 0.298) mg\/dl between deficiency and normal, 0.038\n                    (\u22120.216, 0.292) mg\/dl between insufficiency and normal, and\n                    0.034 (\u22120.216, 0.283) mg\/dl between deficiency and\n                    insufficiency. In conclusion, increasing serum uric acid might be associated\n                    with increasing 25(OH)D level, while vitamin D deficiency is associated with\n                    hyperuricemia. These reverse relationships should be further evaluated in a\n                    longitudinal study.<\/jats:p>","DOI":"10.1055\/a-1240-5850","type":"journal-article","created":{"date-parts":[[2020,10,13]],"date-time":"2020-10-13T18:36:42Z","timestamp":1602614202000},"page":"732-741","source":"Crossref","is-referenced-by-count":39,"title":["Association Between Vitamin D and Uric Acid in Adults: A Systematic\n                    Review and Meta-Analysis"],"prefix":"10.1055","volume":"52","author":[{"given":"Ronny","family":"Isnuwardana","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology and Biostatistics, Faculty of\n                    Medicine, Ramathibodi Hospital, Mahidol University, Bangkok,\n                    Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjeev","family":"Bijukchhe","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology and Biostatistics, Faculty of\n                    Medicine, Ramathibodi Hospital, Mahidol University, Bangkok,\n                    Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6324-2312","authenticated-orcid":false,"given":"Kunlawat","family":"Thadanipon","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology and Biostatistics, Faculty of\n                    Medicine, Ramathibodi Hospital, Mahidol University, Bangkok,\n                    Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atiporn","family":"Ingsathit","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology and Biostatistics, Faculty of\n                    Medicine, Ramathibodi Hospital, Mahidol University, Bangkok,\n                    Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ammarin","family":"Thakkinstian","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology and 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Palacios","year":"2014","journal-title":"J Steroid Biochem Mol Biol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1080s","DOI":"10.1093\/ajcn\/87.4.1080S","article-title":"Vitamin D deficiency: A worldwide problem with health consequences","volume":"87","author":"M F Holick","year":"2008","journal-title":"Am J Clin Nutr"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1186\/1471-2458-11-853","article-title":"Regional variation and determinants of vitamin D status in sunshine-abundant\n                    Thailand","volume":"11","author":"L O Chailurkit","year":"2011","journal-title":"BMC Public Health"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1016\/j.clnu.2010.06.009","article-title":"Vitamin D status in a sunny country: where has the sun gone?","volume":"29","author":"M D Unger","year":"2010","journal-title":"Clin Nutr"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1007\/s00394-010-0138-3","article-title":"Association of serum 25-hydroxyvitamin D with the risk of death in a general\n                    older population in Finland","volume":"50","author":"J K Virtanen","year":"2011","journal-title":"Eur J Nutr"},{"key":"ref8","first-page":"1","article-title":"Effectiveness and safety of vitamin D in relation to bone health","volume":"158","author":"A Cranney","year":"2007","journal-title":"Evid Rep Technol Assess (Full Rep)"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1038\/nrc3691","article-title":"The role of vitamin D in reducing cancer risk and progression","volume":"14","author":"D Feldman","year":"2014","journal-title":"Nat Rev Cancer"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1179\/1973947815Y.0000000043","article-title":"Vitamin D and tuberculosis: A review on a hot topic","volume":"27","author":"L Facchini","year":"2015","journal-title":"J Chemother"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1038\/ejcn.2011.118","article-title":"Vitamin D and type 2 diabetes: A systematic review","volume":"65","author":"J Mitri","year":"2011","journal-title":"Eur J Clin Nutr"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1016\/S2213-8587(14)70113-5","article-title":"Association of vitamin D status with arterial blood pressure and hypertension\n                    risk: A mendelian randomisation study","volume":"2","author":"K S Vimaleswaran","year":"2014","journal-title":"Lancet Diabetes Endocrinol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1016\/j.clnu.2014.05.010","article-title":"Vitamin D status and risk of metabolic syndrome among non-diabetic young\n                    adults","volume":"34","author":"C Y Huang","year":"2015","journal-title":"Clin Nutr"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1161\/CIRCRESAHA.113.301241","article-title":"Vitamin D and cardiovascular disease","volume":"114","author":"P E Norman","year":"2014","journal-title":"Circ Res"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1136\/archdischild-2014-307214","article-title":"Sunshine and vitamin D","volume":"101","author":"V Saraff","year":"2016","journal-title":"Arch Dis Child"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1210\/jc.2010-0980","article-title":"Enhanced excretion of vitamin D binding protein in type 1 diabetes: a role in\n                    vitamin D deficiency?","volume":"96","author":"K M Thrailkill","year":"2011","journal-title":"J Clin Endocrinol Metab"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"115","DOI":"10.2340\/00015555-0980","article-title":"Factors influencing vitamin D status","volume":"91","author":"W G Tsiaras","year":"2011","journal-title":"Acta Derm Venereol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1007\/s10072-015-2401-0","article-title":"Vitamin D receptor polymorphisms and 25-hydroxyvitamin D in a group of Sicilian\n                    multiple sclerosis patients","volume":"37","author":"L Agnello","year":"2016","journal-title":"Neurol Sci"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1007\/s12031-018-1152-9","article-title":"CYP27A1, CYP24A1, and RXR-\u03b1 Polymorphisms, Vitamin D, and Multiple\n                    Sclerosis: a Pilot Study","volume":"66","author":"L Agnello","year":"2018","journal-title":"J Mol Neurosci"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1002\/jnr.24133","article-title":"Association of CYP2R1 rs10766197 with MS risk and disease progression","volume":"96","author":"C Scazzone","year":"2018","journal-title":"J Neurosci Res"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"318","DOI":"10.3945\/jn.115.223388","article-title":"Genetics, diet, and season are associated with serum 25-hydroxycholecalciferol\n                    concentration in a Yup\u2019ik Study Population from Southwestern Alaska","volume":"146","author":"A E Fohner","year":"2016","journal-title":"J Nutr"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.gene.2018.08.056","article-title":"Effects of CYP2R1 gene variants on vitamin D levels and status: A systematic\n                    review and meta-analysis","volume":"678","author":"L Duan","year":"2018","journal-title":"Gene"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"1701","DOI":"10.1002\/jbmr.2164","article-title":"Association of serum uric acid and incident nonspine fractures in elderly men:\n                    The Osteoporotic Fractures in Men (MrOS) study","volume":"29","author":"N E Lane","year":"2014","journal-title":"J Bone Miner Res"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1002\/jbmr.286","article-title":"Serum uric acid is associated with bone health in older men: A cross-sectional\n                    population-based study","volume":"26","author":"I Nabipour","year":"2011","journal-title":"J Bone Miner Res"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"e61159","DOI":"10.1371\/journal.pone.0061159","article-title":"Association between vitamin D insufficiency and elevated serum uric acid among\n                    middle-aged and elderly Chinese Han women","volume":"8","author":"H Peng","year":"2013","journal-title":"PLoS One"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"182","DOI":"10.5262\/tndt.2016.1002.10","article-title":"Association between elevated serum uric acid and vitamin D insufficiency among\n                    the middle-aged and elderly population","volume":"25","author":"M Takir","year":"2016","journal-title":"Turk Nephrol Dial Transplant J"},{"key":"ref27","first-page":"2528956","article-title":"Higher serum uric acid is associated with higher bone mineral density in Chinese\n                    men with type 2 diabetes mellitus","author":"D D Zhao","year":"2016","journal-title":"Int J Endocrinol"},{"key":"ref28","first-page":"509","article-title":"Correlation between serum 25 hydroxy vitamin D3 and laboratory risk markers of\n                    cardiovascular diseases in type 2 diabetic patients","volume":"30","author":"S Bonakdaran","year":"2009","journal-title":"Saudi Med J"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"e0123097","DOI":"10.1371\/journal.pone.0123097","article-title":"Total 25-hydroxyvitamin D concentration as a predictor for all-cause death and\n                    cardiovascular event risk among ethnic Chinese adults: A cohort study in a\n                    Taiwan community","volume":"10","author":"K L Chien","year":"2015","journal-title":"PLoS One"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"732","DOI":"10.5114\/aoms.2017.68237","article-title":"Vitamin D deficiency and non-lipid biomarkers of cardiovascular risk","volume":"13","author":"K F Faridi","year":"2017","journal-title":"Arch Med Sci"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1159\/000454952","article-title":"The association of vitamin d status and vitamin d replacement therapy with\n                    glycemic control, serum uric acid levels, and microalbuminuria in patients with\n                    type 2 diabetes and chronic kidney disease","volume":"26","author":"S Sipahi","year":"2017","journal-title":"Med Princ Pract"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"262","DOI":"10.21101\/cejph.a3749","article-title":"Vitamin D status and health correlates among apparently healthy participants in\n                    an urban, sunny region","volume":"20","author":"N Vallianou","year":"2012","journal-title":"Cent Eur J Public Health"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"e0147601","DOI":"10.1371\/journal.pone.0147601","article-title":"Panethnic differences in blood pressure in Europe: A systematic review and\n                    meta-analysis","volume":"11","author":"P A Modesti","year":"2016","journal-title":"PLoS One"},{"key":"ref35","volume-title":"A revised tool for assessing risk of bias in randomized trials","author":"JPTS J Higgins","year":"2016"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"i4919","DOI":"10.1136\/bmj.i4919","article-title":"ROBINS-I: A tool for assessing risk of bias in non-randomised studies of\n                    interventions","volume":"355","author":"JA C Sterne","year":"2016","journal-title":"BMJ"},{"key":"ref37","volume-title":"Statistical Methods for Examining Heterogeneity and Combining Results from\n                    Several Studies in Meta-Analysis","author":"J J Deeks","year":"2008"},{"key":"ref38","volume-title":"Why and how Sources of Heterogeneity Should be Investigated","author":"S G Thompson","year":"2008"},{"key":"ref39","volume-title":"and Dealing with Publication and Other Biases","author":"JA C Sterne","year":"2008"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"e76654","DOI":"10.1371\/journal.pone.0076654","article-title":"Graphical tools for network meta-analysis in STATA","volume":"8","author":"A Chaimani","year":"2013","journal-title":"PLoS One"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1007\/s11739-016-1583-7","article-title":"Network meta-analysis: An introduction for clinicians","volume":"12","author":"B Rouse","year":"2017","journal-title":"Intern Emerg Med"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1002\/jrsm.1044","article-title":"Consistency and inconsistency in network meta-analysis: Concepts and models for\n                    multi-arm studies","volume":"3","author":"JP T Higgins","year":"2012","journal-title":"Res Synth Meth"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1016\/S0895-4356(01)00377-8","article-title":"Funnel plots for detecting bias in meta-analysis: Guidelines on choice of\n                    axis","volume":"54","author":"J A Sterne","year":"2001","journal-title":"J Clin Epidemiol"},{"key":"ref44","first-page":"162","article-title":"The association between serum uric acid and 25-hydroxyvitamin D in peritoneal\n                    dialysis patients","volume":"27","author":"S Bakird\u00f6gen","year":"2018","journal-title":"Turk Nephrol Dial Transplant J"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1159\/000342748","article-title":"Vitamin D status and parathyroid hormone levels in patients with obstructive\n                    sleep apnea","volume":"86","author":"A Barcelo","year":"2013","journal-title":"Respiration"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1016\/j.redox.2014.01.024","article-title":"Vitamin D deficiency associates with \u03b3-tocopherol and quadriceps\n                    weakness but not inflammatory cytokines in subjects with knee\n                    osteoarthritis","volume":"2","author":"T Barker","year":"2014","journal-title":"Redox Biol"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.dsx.2016.06.007","article-title":"The role of vitamin D, obesity and physical exercise in regulation of glycemia\n                    in type 2 diabetes mellitus patients","volume":"10","author":"A Bener","year":"2016","journal-title":"Diabetes Metab Syndr"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1016\/j.jhep.2015.06.025","article-title":"Association of baseline vitamin D levels with clinical parameters and treatment\n                    outcomes in chronic hepatitis B","volume":"63","author":"H L Chan","year":"2015","journal-title":"J Hepatol"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"4304","DOI":"10.12659\/MSM.904755","article-title":"Association between 25-Hydroxyvitamin D and epicardial adipose tissue in Chinese\n                    non-obese patients with type 2 diabetes","volume":"23","author":"X Chen","year":"2017","journal-title":"Med Sci Monit"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"e40985","DOI":"10.5812\/semj40985","article-title":"Relationship between vitamin D deficiency and metabolic syndrome in renal\n                    transplant patients in Mashhad, Iran","volume":"18","author":"G Jalali","year":"2017","journal-title":"Shiraz E Med J"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"1326","DOI":"10.3349\/ymj.2014.55.5.1326","article-title":"Role of 1,25-dihydroxy vitamin D3 and parathyroid hormone in urinary calcium\n                    excretion in calcium stone formers","volume":"55","author":"W T Kim","year":"2014","journal-title":"Yonsei Med J"},{"key":"ref52","first-page":"216","article-title":"Clinical and laboratory determinants of low serum level of 25-hydroxyvitamin D\n                    during escalation of pharmacotherapy in heart failure patients","volume":"12","author":"K Myrda","year":"2015","journal-title":"Kardiochir Torakochirurgia Pol"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.atherosclerosis.2016.05.019","article-title":"Vitamin D status, diabetes mellitus and coronary artery disease in patients\n                    undergoing coronary angiography","volume":"250","author":"M Nardin","year":"2016","journal-title":"Atherosclerosis"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"5983","DOI":"10.7314\/APJCP.2015.16.14.5983","article-title":"Serum 25-hydroxyvitamin D Insufficiency in B-Chronic Lymphoid Leukemia at the\n                    Time of Disease Presentation in Pakistan","volume":"16","author":"S Parveen","year":"2015","journal-title":"Asian Pac J Cancer Prev"},{"key":"ref55","first-page":"84","article-title":"Vitamin D status among individuals attended in Health Home Care Centre,\n                    Lalitpur, Nepal","volume":"14","author":"S Shrestha","year":"2012","journal-title":"Nepal Med Coll J"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1055\/s-0043-100114","article-title":"Does Vitamin D Status Correlate with Cardiometabolic Risk Factors in Adults with\n                    Growth Hormone Deficiency?","volume":"49","author":"I Uzunova","year":"2017","journal-title":"Horm Metab Res"},{"key":"ref57","first-page":"3510275","article-title":"Serum 25-Hydroxyvitamin D3 Levels Are Associated with Carotid Intima-Media\n                    Thickness and Carotid Atherosclerotic Plaque in Type 2 Diabetic Patients","author":"Y Wang","year":"2017","journal-title":"J Diabetes Res"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1177\/0300060515593765","article-title":"Vitamin D deficiency and related risk factors in patients with diabetic\n                    nephropathy","volume":"44","author":"X Xiao","year":"2016","journal-title":"J Int Med Res"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.dsx.2012.05.007","article-title":"Is vitamin D status a predictor glycaemic regulation and cardiac complication in\n                    type 2 diabetes mellitus patients?","volume":"6","author":"H Yilmaz","year":"2012","journal-title":"Diabetes Metab Syndr"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.2147\/CIA.S90233","article-title":"Significant association between parathyroid hormone and uric acid level in\n                    men","volume":"10","author":"K Y Chin","year":"2015","journal-title":"Clin Interv Aging"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"1989","DOI":"10.1007\/s00198-015-3083-4","article-title":"Serum uric acid is associated with quantitative ultrasound parameters in men:\n                    Data from the Camargo cohort","volume":"26","author":"J L Hernandez","year":"2015","journal-title":"Osteoporos Int"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1007\/s00198-016-3792-3","article-title":"Uric acid and bone mineral density in postmenopausal osteoporotic women: the\n                    link lies within the fat","volume":"28","author":"M Pirro","year":"2017","journal-title":"Osteoporos Int"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"1498","DOI":"10.1016\/j.metabol.2016.07.005","article-title":"Associations of fibroblast growth factor 23 with urate metabolism in patients\n                    with chronic kidney disease","volume":"65","author":"T Sakoh","year":"2016","journal-title":"Metabolism"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"163","DOI":"10.5262\/tndt.2011.1002.08","article-title":"The association between uric acid and vitamin D levels in patients with chronic\n                    kidney disease","volume":"20","author":"E \u015eeng\u00fcl","year":"2011","journal-title":"Turk Nephrol Dial Transplant J"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.bone.2015.06.005","article-title":"Serum uric acid and incident osteoporotic fractures in old people: The PRO.V.A\n                    study","volume":"79","author":"N Veronese","year":"2015","journal-title":"Bone"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.metabol.2013.09.018","article-title":"Uric acid suppresses 1 alpha hydroxylase in vitro and in vivo","volume":"63","author":"W Chen","year":"2014","journal-title":"Metab-Clin Exp"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"3273","DOI":"10.1210\/jc.2008-1532","article-title":"Heritability and environmental factors affecting vitamin D status in rural\n                    Chinese adolescent twins","volume":"94","author":"L M Arguelles","year":"2009","journal-title":"J Clin Endocrinol Metab"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1038\/ng.2500","article-title":"Genome-wide association analyses identify 18 new loci associated with serum\n                    urate concentrations","volume":"45","author":"A K\u00f6ttgen","year":"2013","journal-title":"Nat Genet"},{"key":"ref69","doi-asserted-by":"crossref","first-page":"3156","DOI":"10.1681\/ASN.2007040426","article-title":"Genome scan for determinants of serum uric acid variability","volume":"18","author":"S D Nath","year":"2007","journal-title":"J Am Soc Nephrol"},{"key":"ref70","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1016\/j.jsbmb.2006.12.053","article-title":"A genome-wide linkage scan for 25-OH-D(3) and 1,25-(OH)2-D3 serum levels in\n                    asthma families","volume":"103","author":"M Wjst","year":"2007","journal-title":"J Steroid Biochem Mol Biol"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/1755-8794-7-10","article-title":"A genome-wide association study identifies common variants influencing serum\n                    uric acid concentrations in a Chinese population","volume":"7","author":"B Yang","year":"2014","journal-title":"BMC Med Genomics"},{"key":"ref72","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1038\/jhg.2013.84","article-title":"Genetic variant in vitamin D binding protein is associated with serum\n                    25-hydroxyvitamin D and vitamin D insufficiency in southern Chinese","volume":"58","author":"C L Cheung","year":"2013","journal-title":"J Hum Genet"},{"key":"ref73","doi-asserted-by":"crossref","first-page":"1784","DOI":"10.1002\/jbmr.1926","article-title":"An analysis of the association between the vitamin D pathway and serum\n                    25-hydroxyvitamin D levels in a healthy Chinese population","volume":"28","author":"Z Zhang","year":"2013","journal-title":"J Bone Miner Res"},{"key":"ref74","doi-asserted-by":"crossref","first-page":"14528","DOI":"10.1038\/srep14528","article-title":"Potential causal associations between vitamin D and uric acid: Bidirectional\n                    mediation analysis","volume":"5","author":"A Thakkinstian","year":"2015","journal-title":"Sci Rep"},{"key":"ref75","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1007\/s00592-015-0825-x","article-title":"Association of serum uric acid levels with the risk of development or\n                    progression of albuminuria among Japanese patients with type 2 diabetes: A\n                    prospective cohort study [Diabetes Distress and Care Registry at Tenri (DDCRT\n                    10)]","volume":"53","author":"Y Hayashino","year":"2016","journal-title":"Acta Diabetol"},{"key":"ref76","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.7754\/Clin.Lab.2013.130830","article-title":"Inhibition of xanthine oxidase and exercise on serum uric acid, 25(OH)D3, and\n                    calcium concentrations","volume":"60","author":"F Sanchis-Gomar","year":"2014","journal-title":"Clin Lab"},{"key":"ref77","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1007\/s00774-005-0647-y","article-title":"Causes of secondary hyperparathyroidism in a healthy population: The Tromso\n                    study","volume":"24","author":"F Saleh","year":"2006","journal-title":"J Bone Miner Metab"},{"key":"ref78","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1016\/j.kint.2016.09.041","article-title":"Down-regulation of ABCG2, a urate exporter, by parathyroid 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