{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T19:10:42Z","timestamp":1761419442824},"reference-count":47,"publisher":"Georg Thieme Verlag KG","issue":"03","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Fortschr Neurol Psychiatr"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title><jats:p>Narkolepsie ist eine Hypersomnolenz-Erkrankung, die mit einer St\u00f6rung der Wach-Schlaf-Regulation einhergeht. Leitsymptome sind exzessive Tagesschl\u00e4frigkeit und Kataplexien. Zudem treten hypnagogene\/hypnopompe Halluzinationen, Schlafl\u00e4hmungen und gest\u00f6rter Nachtschlaf auf. Es werden zwei Formen unterschieden. Bei der Narkolepsie Typ 1, fr\u00fcher Narkolepsie mit Kataplexie, besteht eine Hypocretin-Defizienz. Die Ursache der Narkolepsie Typ 2, fr\u00fcher Narkolepsie ohne Kataplexie, ist im Wesentlichen ungekl\u00e4rt. Zur Diagnosestellung ist ein multimodaler Ansatz notwendig. Die Latenz zwischen Erkrankungsbeginn und Diagnosestellung in Europa betr\u00e4gt im Mittel 14 Jahre. Es bestehen erhebliche Probleme in der Versorgung von Menschen mit Narkolepsie. Die in aller Regel lebenslange Behandlung der Narkolepsie umfasst sowohl nichtmedikament\u00f6se Strategien als auch die symptomatische medikament\u00f6se Behandlung.<\/jats:p>","DOI":"10.1055\/a-1244-2612","type":"journal-article","created":{"date-parts":[[2020,12,19]],"date-time":"2020-12-19T00:15:22Z","timestamp":1608336922000},"page":"103-113","source":"Crossref","is-referenced-by-count":2,"title":["Narkolepsie im Erwachsenenalter: Definition, \u00c4tiologie und Behandlung"],"prefix":"10.1055","volume":"89","author":[{"given":"Michael","family":"Malter","sequence":"additional","affiliation":[{"name":"Universit\u00e4t K\u00f6ln, Klinik und Poliklinik f\u00fcr Neurologie"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janina","family":"Neuneier","sequence":"additional","affiliation":[{"name":"Universit\u00e4t K\u00f6ln, Klinik und Poliklinik f\u00fcr Neurologie"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annika","family":"Triller","sequence":"additional","affiliation":[{"name":"Zentrum f\u00fcr Narkolepsie\/Hypersomnien, Klin. Schlaf- und Neuroimmunologie, Institut f\u00fcr Immunologie, Universit\u00e4t Witten\/Herdecke"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulf","family":"Kallweit","sequence":"additional","affiliation":[{"name":"Zentrum f\u00fcr Narkolepsie\/Hypersomnien, Klin. 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Latorre","year":"2018","journal-title":"Nature"},{"key":"ref4","first-page":"E12323-E12332","article-title":"Autoimmunity to hypocretin and molecular mimicry to flu in type 1 narcolepsy","volume":"115","author":"G Luo","year":"2018","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1611","DOI":"10.1080\/03007995.2016.1208643","article-title":"The ICSD-3 and DSM-5 guidelines for diagnosing narcolepsy: Clinical relevance and practicality","volume":"32","author":"C Ruoff","year":"2016","journal-title":"Curr Med Res Opin"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1111\/jsr.12374","article-title":"The European Narcolepsy Network (EU-NN) database","volume":"25","author":"R Khatami","year":"2016","journal-title":"J Sleep Res"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1038\/s41582-019-0226-9","article-title":"Narcolepsy - clinical spectrum, aetiopathophysiology, diagnosis and treatment","volume":"15","author":"CLA Bassetti","year":"2019","journal-title":"Nat Rev Neurol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"955","DOI":"10.5664\/jcsm.3004","article-title":"Disrupted nighttime sleep in narcolepsy","volume":"9","author":"T Roth","year":"2013","journal-title":"J Clin Sleep Med"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1159\/000348719","article-title":"Sleep-disordered breathing and periodic limb movements in narcolepsy with cataplexy: A systematic analysis of 35 consecutive patients","volume":"70","author":"F Pizza","year":"2013","journal-title":"Eur Neurol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.sleep.2017.11.1125","article-title":"Comorbidities in a community sample of narcolepsy","volume":"43","author":"A Cohen","year":"2018","journal-title":"Sleep Med"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"171","DOI":"10.4088\/JCP.15m10262","article-title":"High rates of psychiatric comorbidity in narcolepsy: findings from the Burden of Narcolepsy Disease (BOND) study of 9,312 patients in the United States","volume":"78","author":"CM Ruoff","year":"2017","journal-title":"J Clin Psychiatry"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1002\/ana.410350612","article-title":"The prevalence of narcolepsy: An epidemiological study of the Finnish Twin Cohort","volume":"35","author":"C Hublin","year":"1994","journal-title":"Ann Neurol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1093\/sleep\/25.2.197","article-title":"The epidemiology of narcolepsy in Olmsted County, Minnesota: A population-based study","volume":"25","author":"MH Silber","year":"2002","journal-title":"Sleep"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.5665\/sleep.5060","article-title":"Incidence of Narcolepsy in Germany","volume":"38","author":"D Oberle","year":"2015","journal-title":"Sleep"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"2029","DOI":"10.1212\/WNL.57.11.2029","article-title":"Age at onset of narcolepsy in two large populations of patients in France and Quebec","volume":"57","author":"Y Dauvilliers","year":"2001","journal-title":"Neurology"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1055\/s-0035-1550152","article-title":"Narcolepsy during childhood: an update","volume":"46","author":"FL Rocca","year":"2015","journal-title":"Neuropediatrics"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"1 page following 696","DOI":"10.1016\/S0092-8674(00)80949-6","article-title":"Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior","volume":"92","author":"T Sakurai","year":"1998","journal-title":"Cell"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1073\/pnas.95.1.322","article-title":"The hypocretins: Hypothalamus-specific peptides with neuroexcitatory activity","volume":"95","author":"L de Lecea","year":"1998","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1016\/j.neuron.2017.01.014","article-title":"Neural Circuitry of Wakefulness and Sleep","volume":"93","author":"TE Scammell","year":"2017","journal-title":"Neuron"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"19","DOI":"10.5665\/sleep.3300","article-title":"DQB1 locus alone explains most of the risk and protection in narcolepsy with cataplexy in Europe","volume":"37","author":"M Tafti","year":"2014","journal-title":"Sleep"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1056\/NEJM200103013440918","article-title":"Narcolepsy and the HLA 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Omokawa","year":"2016","journal-title":"Am J Med Genet A"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1007\/s11910-014-0522-0","article-title":"Cataplexy and sleep disorders in Niemann-Pick type C disease","volume":"15","author":"S Nevsimalova","year":"2015","journal-title":"Curr Neurol Neurosci Rep"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1093\/sleep\/28.1.113","article-title":"Practice parameters for clinical use of the multiple sleep latency test and the maintenance of wakefulness test","volume":"28","author":"MR Littner","year":"2005","journal-title":"Sleep"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1378\/chest.14-0970","article-title":"International classification of sleep disorders-third edition: Highlights and modifications","volume":"146","author":"MJ Sateia","year":"2014","journal-title":"Chest"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"1609","DOI":"10.1093\/brain\/awl079","article-title":"Correlates of sleep-onset REM periods during the Multiple Sleep Latency Test in community adults","volume":"129","author":"E Mignot","year":"2006","journal-title":"Brain"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"789","DOI":"10.5664\/jcsm.2922","article-title":"Test-retest reliability of the multiple sleep latency test in narcolepsy without cataplexy and idiopathic hypersomnia","volume":"9","author":"LM Trotti","year":"2013","journal-title":"J Clin Sleep Med"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"2253","DOI":"10.1212\/WNL.57.12.2253","article-title":"CSF hypocretin\/orexin levels in narcolepsy and other neurological conditions","volume":"57","author":"B Ripley","year":"2001","journal-title":"Neurology"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"2137","DOI":"10.1007\/s00415-019-09365-2","article-title":"The Swiss Narcolepsy Scale (SNS) and its short form (sSNS) for the discrimination of narcolepsy in patients with hypersomnolence: A cohort study based on the Bern sleep-wake database","volume":"266","author":"P Bargiotas","year":"2019","journal-title":"J Neurol"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"e0129386","DOI":"10.1371\/journal.pone.0129386","article-title":"Car crashes and central disorders of hypersomnolence: a French study","volume":"10","author":"F Pizza","year":"2015","journal-title":"PLoS One"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"2654","DOI":"10.1056\/NEJMra1500587","article-title":"Narcolepsy","volume":"373","author":"TE Scammell","year":"2015","journal-title":"N Engl J 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US Modafinil in Narcolepsy multicenter study group","volume":"43","author":"[Anonym]","year":"1998","journal-title":"Ann Neurol"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1212\/WNL.54.5.1166","article-title":"Randomized trial of modafinil as a treatment for the excessive daytime somnolence of narcolepsy: US Modafinil in Narcolepsy multicenter study group","volume":"54","author":"[Anonym]","year":"2000","journal-title":"Neurology"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1007\/s40265-019-01123-y","article-title":"Solriamfetol: First Global Approval","volume":"79","author":"A Markham","year":"2019","journal-title":"Drugs"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/S1474-4422(16)30333-7","article-title":"Safety and efficacy of pitolisant on cataplexy in patients with narcolepsy: A randomised, double-blind, placebo-controlled trial","volume":"16","author":"Z Szakacs","year":"2017","journal-title":"Lancet Neurol"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"391","DOI":"10.5664\/jcsm.26368","article-title":"A double-blind, placebo-controlled study demonstrates sodium oxybate is effective for the treatment of excessive daytime sleepiness in narcolepsy","volume":"1","author":"Group XIS","year":"2005","journal-title":"J Clin Sleep Med"},{"key":"ref48","first-page":"42","article-title":"A randomized, double blind, placebo-controlled multicenter trial comparing the effects of three doses of orally administered sodium oxybate with placebo for the treatment of narcolepsy","volume":"25","author":"[Anonym]","year":"2002","journal-title":"Sleep"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1093\/sleep\/27.7.1327","article-title":"A pilot study on the effects of sodium oxybate on sleep architecture and daytime alertness in narcolepsy","volume":"27","author":"M Mamelak","year":"2004","journal-title":"Sleep"},{"key":"ref50","first-page":"31","article-title":"A 12-month, open-label, multicenter extension trial of orally administered sodium oxybate for the treatment of narcolepsy","volume":"26","author":"[Anonym]","year":"2003","journal-title":"Sleep"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1046\/j.1365-2869.1998.00093.x","article-title":"The clinical diagnosis of the narcoleptic syndrome","volume":"7","author":"JD Parkes","year":"1998","journal-title":"J Sleep Res"}],"container-title":["Fortschritte der Neurologie \u00b7 Psychiatrie"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-1244-2612.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,3,9]],"date-time":"2021-03-09T00:33:14Z","timestamp":1615249994000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-1244-2612"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12,18]]},"references-count":47,"journal-issue":{"issue":"03","published-online":{"date-parts":[[2021,2,1]]},"published-print":{"date-parts":[[2021,3]]}},"URL":"https:\/\/doi.org\/10.1055\/a-1244-2612","relation":{},"ISSN":["0720-4299","1439-3522"],"issn-type":[{"value":"0720-4299","type":"print"},{"value":"1439-3522","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,12,18]]}}}