{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T14:28:13Z","timestamp":1758810493207},"reference-count":23,"publisher":"Georg Thieme Verlag KG","issue":"01\/02","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Fortschr Neurol Psychiatr"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:p>Die tiefe Hirnstimulation ist eine etablierte und evidenzbasierte Therapieoption f\u00fcr die Behandlung des fortgeschrittenen Morbus Parkinson. Es handelt sich um eine symptomatische Behandlung mit dem prim\u00e4ren Ziel, die Lebensqualit\u00e4t des Patienten zu verbessern. Der operative Eingriff gilt als relativ komplikationsarm.<\/jats:p>","DOI":"10.1055\/a-1260-0401","type":"journal-article","created":{"date-parts":[[2021,1,19]],"date-time":"2021-01-19T23:34:28Z","timestamp":1611099268000},"page":"56-65","source":"Crossref","is-referenced-by-count":2,"title":["Tiefe Hirnstimulation bei Morbus Parkinson"],"prefix":"10.1055","volume":"89","author":[{"given":"Petyo","family":"Nikolov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan Jun","family":"Groiss","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alfons","family":"Schnitzler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2021,1,19]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1756286419838096","DOI":"10.1177\/1756286419838096","article-title":"An update on best practice of deep brain stimulation in Parkinson\u2019s disease","volume":"12","author":"CJ Hartmann","year":"2019","journal-title":"Ther Adv Neurol Disord"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"2498","DOI":"10.1056\/NEJMoa033447","article-title":"Levodopa and the progression of Parkinson\u2019s disease","volume":"351","author":"S Fahn","year":"2004","journal-title":"N Engl J Med"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1002\/mds.27386","article-title":"Nonmotor Complications of Levodopa: Phenomenology, Risk Factors, and Imaging Features","volume":"33","author":"K Ray Chaudhuri","year":"2018","journal-title":"Mov Disord Off J Mov Disord Soc"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.parkreldis.2018.05.011","article-title":"Low body mass index and life prognosis in Parkinson\u2019s disease","volume":"55","author":"K Park","year":"2018","journal-title":"Parkinsonism Relat Disord"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1159\/000098600","article-title":"Acute and long-term effects of subthalamic nucleus stimulation in Parkinson\u2019s disease","volume":"62","author":"AL Benabid","year":"1994","journal-title":"Stereotact Funct Neurosurg"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1152\/jn.00989.2003","article-title":"Cellular effects of deep brain stimulation: model-based analysis of activation and inhibition","volume":"91","author":"CC McIntyre","year":"2004","journal-title":"J Neurophysiol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1126\/science.1167093","article-title":"Optical deconstruction of parkinsonian neural circuitry","volume":"324","author":"V Gradinaru","year":"2009","journal-title":"Science"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"9909","DOI":"10.1523\/JNEUROSCI.0275-12.2012","article-title":"Beta reactivity, prospective facilitation of executive processing, and its dependence on dopaminergic therapy in Parkinson\u2019s disease","volume":"32","author":"A Oswal","year":"2012","journal-title":"J Neurosci Off J Soc Neurosci"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/S1474-4422(18)30035-8","article-title":"Behavioural outcomes of subthalamic stimulation and medical therapy versus medical therapy alone for Parkinson\u2019s disease with early motor complications (EARLYSTIM trial): secondary analysis of an open-label randomised trial","volume":"17","author":"E Lhomm\u00e9e","year":"2018","journal-title":"Lancet Neurol."},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1212\/01.wnl.0000260059.77107.c2","article-title":"Is DBS-STN appropriate to treat severe Parkinson disease in an elderly population?","volume":"68","author":"P-P Derost","year":"2007","journal-title":"Neurology"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1056\/NEJMoa1205158","article-title":"Neurostimulation for Parkinson\u2019s disease with early motor complications","volume":"368","author":"WMM Schuepbach","year":"2013","journal-title":"N Engl J Med"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"132","DOI":"10.3171\/2013.10.JNS131225","article-title":"Risks of common complications in deep brain stimulation surgery: management and avoidance","volume":"120","author":"AJ Fenoy","year":"2014","journal-title":"J Neurosurg"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"S181","DOI":"10.1002\/mds.10162","article-title":"Introduction to the programming of deep brain stimulators","volume":"17","author":"J Volkmann","year":"2002","journal-title":"Mov Disord"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1002\/mds.27863","article-title":"Short Versus Conventional Pulse-Width Deep Brain Stimulation in Parkinson\u2019s Disease: A Randomized Crossover Comparison","volume":"35","author":"V Dayal","year":"2020","journal-title":"Mov Disord Off J Mov Disord Soc"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1212\/01.wnl.0000303972.16279.46","article-title":"STN-DBS frequency effects on freezing of gait in advanced Parkinson disease","volume":"71","author":"C Moreau","year":"2008","journal-title":"Neurology"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"1380","DOI":"10.1002\/mds.27093","article-title":"Directional DBS increases side-effect thresholds-A prospective, double-blind trial","volume":"32","author":"TA Dembek","year":"2017","journal-title":"Mov Disord Off J Mov Disord Soc"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1016\/j.brs.2017.12.015","article-title":"Thalamic Directional Deep Brain Stimulation for tremor: Spend less, get more","volume":"11","author":"P Rebelo","year":"2018","journal-title":"Brain Stimulat."},{"key":"ref18","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1056\/NEJMoa060281","article-title":"A randomized trial of deep-brain stimulation for Parkinson\u2019s disease","volume":"355","author":"G Deuschl","year":"2006","journal-title":"N Engl J Med"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/S1474-4422(10)70093-4","article-title":"Deep brain stimulation plus best medical therapy versus best medical therapy alone for advanced Parkinson\u2019s disease (PD SURG trial): a randomised, open-label trial","volume":"9","author":"A Williams","year":"2010","journal-title":"Lancet Neurol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/S1474-4422(11)70308-8","article-title":"Subthalamic deep brain stimulation with a constant-current device in Parkinson\u2019s disease: an open-label randomised controlled trial","volume":"11","author":"MS Okun","year":"2012","journal-title":"Lancet Neurol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1001\/jama.2008.929","article-title":"Bilateral deep brain stimulation vs best medical therapy for patients with advanced Parkinson disease: a randomized controlled trial","volume":"301","author":"FM Weaver","year":"2009","journal-title":"JAMA"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"1795","DOI":"10.1002\/mds.27860","article-title":"Deep Brain Stimulation in Movement Disorders: From Experimental Surgery to Evidence-Based Therapy","volume":"34","author":"P Krack","year":"2019","journal-title":"Mov Disord Off J Mov Disord Soc"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1016\/S1474-4422(08)70114-5","article-title":"Neuropsychological and psychiatric changes after deep brain stimulation for Parkinson\u2019s disease: a randomised, multicentre study","volume":"7","author":"K Witt","year":"2008","journal-title":"Lancet Neurol"}],"container-title":["Fortschritte der Neurologie \u00b7 Psychiatrie"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-1260-0401.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,1,19]],"date-time":"2021-01-19T23:34:58Z","timestamp":1611099298000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-1260-0401"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":23,"journal-issue":{"issue":"01\/02","published-online":{"date-parts":[[2021,1,19]]},"published-print":{"date-parts":[[2021,1]]}},"URL":"https:\/\/doi.org\/10.1055\/a-1260-0401","relation":{},"ISSN":["0720-4299","1439-3522"],"issn-type":[{"value":"0720-4299","type":"print"},{"value":"1439-3522","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1]]}}}